Autonomic nervous system function predicts the inflammatory response over three years in newly diagnosed ulcerative colitis patients

Gunterberg, Veronica; Simrén, Magnus; Öhman, Lena; Friberg, Peter; Jones, Michael; Oudenhove, Lukas Van; Strid, Hans

doi:10.1111/nmo.12865

Cited by 26 publications

(20 citation statements)

References 32 publications

(78 reference statements)

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“…Besides, AMY1 gene copy number was comparable between UC patients and controls. Our findings might implicate an altered ANS activity in UC patients, which was consistent with previous studies [ 15 – 17 ].…”

Section: Discussionsupporting

confidence: 93%

“…In humans, the attempts to identify whether ANS alterations are present in UC has not come to a conclusion on the relationship between ANS function and UC disease activity. Nevertheless, a couple of previous studies had demonstrated altered ANS activities in UC patients [ 15 – 17 ], especially an elevated sympathetic nervous activity in this population [ 15 , 16 ]. In the current study, we detected an elevated sAA secretion before and after gustatory stimulation, which also indicated an elevated sympathetic nervous activity in UC patients.…”

Section: Discussionmentioning

confidence: 90%

“…There is growing body of evidence that the ANS abnormalities may play a role in the UC pathophysiology. For example, alterations of the sympathetic nervous activity were detected to sustain local inflammatory mechanisms in the UC animal model [ 14 ], and previous studies had demonstrated altered ANS activities in UC patients [ 15 – 17 ]. More interestingly, an accumulating body of evidence suggests that the psychological disorders are closely associated with the altered ANS activity and that the ANS dysfunction is one of the pathophysiological links between the psychological disorders and a series of somatic diseases [ 18 – 23 ], including UC [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

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Altered Salivary Alpha-Amylase Secretion in Patients with Ulcerative Colitis

Wei

Qiu

et al. 2018

Gastroenterology Research and Practice

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Purpose Patients with ulcerative colitis (UC) frequently present with psychological disturbances as well as dysfunctions of autonomic nervous system (ANS). Salivary alpha-amylase (sAA) secretion is predominantly controlled by sympathetic nervous activity, while salivary fluid secretion is by parasympathetic nervous activity. Thus, it is speculated that alterations of salivary secretion may be addressed in UC populations. Methods Thirty-five UC patients as well as 32 age- and sex-matched healthy controls were enrolled. Saliva samples before and after citric acid stimulation were collected from each participant, and salivary flow rate (SFR) was calculated accordingly. Western blotting and quantitative PCR were applied to measure the sAA level and sAA gene (AMY1) copy number, respectively. The psychological disorders, anxiety and depression, were evaluated by the scoring system of Hospital Anxiety and Depression Scale (HADS) for each participant. Results We observed robustly increased prevalence of anxiety (p < 0.001) as well as depression (p < 0.001) in UC patients relative to controls. Interestingly, we detected elevated basal (p = 0.015) and stimulated (p = 0.021) sAA levels in the UC populations compared to controls. However, no differences were found for basal (p = 0.643) or stimulated (p = 0.402) SFR between the two study groups. Besides, AMY1 gene copy number was comparable between UC patients and controls. Conclusions Our results reveal an overactivity of the sympathetic nervous system and a normal activity of the parasympathetic nervous system in the UC population.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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Altered Salivary Alpha-Amylase Secretion in Patients with Ulcerative Colitis

Wei

Qiu

et al. 2018

Gastroenterology Research and Practice

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“…One explanation for the differences between UC and CD subtypes is that CD can affect any part of the GIT, whereas UC predominantly occurs in the distal colon and rectum, areas that are not innervated by the vagus nerve 3 . Nevertheless, a negative association between parasympathetic activity and inflammation parameters has also been reported in UC, although it remains unclear to what extent the vagus nerve is involved 10 …”

Section: Discussionmentioning

confidence: 99%

“…Pellissier et al have showed that CD patients with low parasympathetic vagal tone demonstrate higher blood tumour necrosis factor alpha (TNF‐α) levels than patients with high vagal tone 9 . Moreover, sympathovagal balance has been correlated with TNF‐α levels in UC and higher parasympathetic tone at onset of UC predicts lower systemic inflammation during the next 3 years 10 …”

Section: Introductionmentioning

confidence: 99%

Vagotomy and subsequent risk of inflammatory bowel disease: a nationwide register‐based matched cohort study

Liu

Wanders

Wirdefeldt

et al. 2020

Aliment Pharmacol Ther

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Background:The vagus nerve provides essential parasympathetic innervation to the gastrointestinal system and is known to have anti-inflammatory properties.Aims: To explore the relationship between vagotomy and the risk of inflammatory bowel disease (IBD) and its major categories: Crohn's disease (CD) and ulcerative colitis (UC). Methods:A matched cohort comprising 15 637 patients undergoing vagotomy was identified through the Swedish Patient Register from 1964 to 2010. Each vagotomised patient was matched for birth year and gender with 40 nonvagotomised individuals on the date of vagotomy. We estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for IBD using flexible parametric models adjusted for matching variables, year of vagotomy, birth country, chronic obstructive pulmonary disease and comorbidity index. Results:We observed 119 (0.8%) patients with vagotomy developed IBD compared to 3377 (0.5%) IBD cases in nonvagotomised individuals. The crude incidence of IBD (per 1000 person-years) was 0.38 for vagotomised patients and 0.25 for nonvagotomised individuals. We observed a time-dependent elevated risk of IBD associated with vagotomy, for instance, the HR (95% CI) was 1.80 (1.40-2.31) at year 5 and 1.49 (1.14-1.96) at year 10 post-vagotomy. The association appeared to be stronger for truncal than selective vagotomy and limited to CD (HR was 3.63 [1.94-6.80] for truncal and 2.06 [1.49-2.84] for selective vagotomy) but not UC (1.36 [0.71-2.62] for truncal and 1.25 [0.95-1.63] for selective vagotomy). Conclusions:We found a positive association between vagotomy and later IBD, particularly for CD. The finding indirectly underlines the beneficial role of the vagal tone in IBD. | 1023 LIU et aL. S U PP O RTI N G I N FO R M ATI O N Additional supporting information will be found online in the Supporting Information section. How to cite this article: Liu B, Wanders A, Wirdefeldt K, et al. Vagotomy and subsequent risk of inflammatory bowel disease: a nationwide register-based matched cohort study. Aliment

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Heart rate variability as a marker and predictor of inflammation, nosocomial infection, and sepsis – A systematic review

Adam¹,

Rupprecht²,

Künstler³

et al. 2023

Autonomic Neuroscience

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Autonomic nervous system function predicts the inflammatory response over three years in newly diagnosed ulcerative colitis patients

Abstract: This study further strengthens the association between the ANS system and intestinal inflammation previously found in animal models and recently in patients with inflammatory bowel disease. These results may have important implications for the pathogenesis and treatment of UC.

Cited by 26 publications

References 32 publications

Altered Salivary Alpha-Amylase Secretion in Patients with Ulcerative Colitis

Altered Salivary Alpha-Amylase Secretion in Patients with Ulcerative Colitis

Vagotomy and subsequent risk of inflammatory bowel disease: a nationwide register‐based matched cohort study

Heart rate variability as a marker and predictor of inflammation, nosocomial infection, and sepsis – A systematic review

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