Autonomic Nerve Function in Rheumatoid Arthritis of Varying Severity

Leden, Ido; Eriksson, Anita; Lilja, B.; Sturfelt, Gunnar; Sundkvist, Göran

doi:10.3109/03009748309102905

Cited by 75 publications

(32 citation statements)

References 13 publications

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“…Several investigators assessed cardiovascular autonomic nerve function in RA patients and observed cardiovascular autonomic nervous system dysfunction [5][6][7][8] .Similar trends for greater fall of SBP in RA patients was noted by Louthreno et al 5 .and less rise of DBP was reported by Sandhu and Allen 6 whereas similar results in both parameters were also reported 2 .…”

Section: Discussionsupporting

confidence: 58%

“…Recently, orthostatic hypotension was found in 8% of RA patients 2 . Though, few studies investigated autonomic function in RA [5][6][7][8][9] , the effect of duration of RA on 10 with duration of disease from one to ten years were enrolled from the Rheumatology wing of the outpatient department of medicine of BSMMU, Dhaka. Age and BMI matched 30 apparently healthy sedentary females were control.…”

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confidence: 99%

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Relationship of Sympathetic Dysfunction with Disease Duration In Female Rheumatoid Arthritis Patients

Ferdousi

Jahan²,

Begum

2015

J Bangladesh Soc Physiol

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Background: Association of increased cardiovascular morbidity and higher sympathetic activity in patients with Rheumatoid arthritis (RA) has been well recognized. Objective: To assess sympathetic nerve function status in Rheumatoid arthritis patients and its relationship to duration of the disease. Methods: This study was carried out in the dept of Physiology Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka during 2010.Sixty female RA patients aged 18-50 years with duration of disease from 1 to 10 years was selected from Rheumatology wing of Medicine OPD of BSMMU. Age and BMI matched female apparently healthy subjects were control. Sympathetic nerve function status was assessed by blood pressure response to orthostatic test and sustained hand grip isometric exercise test. In these two tests, fall in systolic blood pressure (SBP) and rise in diastolic blood pressure (DBP) respectively estimates sympathetic reactivity. For statistical analysis, unpaired students t test and pearsons correlation coefficient test was applied. Results: Mean values of fall of SBP was higher and rise of DBP was lower in RA patients compared to control which was statistically (P<0.001) significant. Again rise of DBP was negatively and fall of SBP was positively correlated with duration of the disease and the relationships were statistically highly significant (p<0.01). Conclusion: The results conclude that sympathetic reflex response was reduced in RA which was deteriorated with duration of disease.

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Section: Discussionsupporting

confidence: 58%

mentioning

confidence: 99%

Relationship of Sympathetic Dysfunction with Disease Duration In Female Rheumatoid Arthritis Patients

Ferdousi

Jahan²,

Begum

2015

J Bangladesh Soc Physiol

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“…Clinically, there are multiple reports of autonomic dysregulation in both juvenile chronic and RA, such as increased resting heart rates and elevated levels of urinary NE metabolites [353] and augmented SNS reflex responses to orthostatic stress [354], the valsalva maneuver [354], deep breathing [355], pupil size [355] and perspiration [356]. These reports suggest increased sympathetic tone.…”

Section: Sympathetic Regulation Of Autoimmune Diseasesmentioning

confidence: 96%

Sympathetic modulation of immunity: Relevance to disease

Bellinger

Millar

Perez

et al. 2008

Cellular Immunology

225

185

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Optimal host defense against pathogens requires cross-talk between the nervous and immune systems. This paper reviews sympathetic-immune interaction, one major communication pathway, and its importance for health and disease. Sympathetic innervation of primary and secondary immune organs is described, as well as evidence for neurotransmission with cells of the immune system as targets. Most research thus far as focused on neural-immune modulation in secondary lymphoid organs, and have revealed complex sympathetic modulation resulting in both potentiation and inhibition of immune functions. SNS-immune interaction may enhance immune readiness during disease-or injury-induced 'fight' responses. Research also indicate that dysregulation of the SNS can significantly affect the progression of immune-mediated diseases. However, a better understanding of neural-immune interactions is needed to develop strategies for treatment of immune-mediated diseases that are designed to return homeostasis and restore normal functioning neural-immune networks.

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“…Sandhu and Allen 13 in 2004 observed lower value of 30 th :15 th ratio whereas others rather found higher values. 6 Leden et al 8 also found abnormal heart rate response to standing in patients with Rheumatoid Arthritis.…”

Section: Discussionmentioning

confidence: 99%

“…[2][3][4] The increased incidence of sudden cardiac death in these group of patients may be related to the decreased vagal drive to the heart. 5 In RA, researchers of different countries [8][9] .Lower values of heart rate response to valsalva maneuver, heart rate response to deep breathing and heart rate response to standing (30 th :15 th ratio) were reported in patients with RA in comparison with those of healthy control. 10- 13 Opposite finding was also reported by some investigators who did not find any cardiovascular autonomic abnormality in patients with rheumatoid arthritis when compared with those of healthy control 14 .…”

mentioning

confidence: 99%

Parasympathetic Nerve Function Status in Female with Rheumatoid Arthritis

Jahan¹,

Begum

Ferdousi

2013

J Bangladesh Soc Physiol

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Background: Sudden cardiac death in patients with Rheumatoid Arthritis has been attributed to the decreased vagal drive to the heart. Objective: To assess cardiac parasympathetic nerve function status in patients with Rheumatoid Arthritis (RA). Methods: This cross sectional study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka from January to December 2010. Sixty female RA patients aged 18-50 years were included in the study group. They were enrolled from the Out Patient Department of Rheumatology Wing of the Department of Medicine, BSMMU, Dhaka. For comparison age matched thirty apparently healthy females were also studied as control. To assess parasympathetic nerve function status, all the subjects were examined by three noninvasive cardiovascular reflex tests such as heart rate response to valsalva maneuver (valsalva ratio), heart rate response to deep breathing and heart rate response to standing (30 th :15 th ratio). For statistical analysis independent sample t test was used. Results: Mean values of valsalva ratio, deep breathing test and 30 th :15 th ratio were significantly (p<0.001) lower in rheumatoid arthritis patients compared to those of healthy control. Conclusion: From this study it may be concluded that lower cardiac parasympathetic nerve activity characterized the autonomic nerve dysfunction in patients with Rheumatoid Arthritis.

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Autonomic Nerve Function in Rheumatoid Arthritis of Varying Severity

Cited by 75 publications

References 13 publications

Relationship of Sympathetic Dysfunction with Disease Duration In Female Rheumatoid Arthritis Patients

Relationship of Sympathetic Dysfunction with Disease Duration In Female Rheumatoid Arthritis Patients

Sympathetic modulation of immunity: Relevance to disease

Parasympathetic Nerve Function Status in Female with Rheumatoid Arthritis

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