Autonomic Manifestations of Long-COVID Syndrome

Hira, Rashmin; Karalasingham, Kavithra; Baker, Jacquie R.; Raj, Satish R.

doi:10.1007/s11910-023-01320-z

Cited by 5 publications

(2 citation statements)

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“…[14][15][16][17] Orthostatic abnormalities including OH, OT, and PoTS have also been identified as a sequel of long covid 5,[18][19][20][21][22][23] which can have a significant impact on day-to-day functioning. 24 Long covid is associated with many diverse abnormalities in the neurological and cardiovascular systems, including abnormal autonomic response ("dysautonomia") 10,23,[25][26][27][28] which has been observed in other post-viral conditions. 29 Symptoms of long covid can be complex and prolonged, 30 many of which overlap with those of OI, and include dizziness, palpitations, tightness or pain in the chest, and tingling in the extremities on standing.…”

Section: Introductionmentioning

confidence: 99%

“…Long covid is associated with many diverse abnormalities in the neurological and cardiovascular systems, including abnormal autonomic response (“dysautonomia”) 10,23,25–28 which has been observed in other post‐viral conditions 29 . Symptoms of long covid can be complex and prolonged, 30 many of which overlap with those of OI, and include dizziness, palpitations, tightness or pain in the chest, and tingling in the extremities on standing 4,20 .…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of orthostatic intolerance in long covid clinic patients and healthy volunteers: A multicenter study

Lee,

Greenwood,

Master

et al. 2024

Journal of Medical Virology

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Orthostatic intolerance (OI), including postural orthostatic tachycardia syndrome (PoTS) and orthostatic hypotension (OH), are often reported in long covid, but published studies are small with inconsistent results. We sought to estimate the prevalence of objective OI in patients attending long covid clinics and healthy volunteers and associations with OI symptoms and comorbidities. Participants with a diagnosis of long covid were recruited from eight UK long covid clinics, and healthy volunteers from general population. All undertook standardized National Aeronautics and Space Administration Lean Test (NLT). Participants' history of typical OI symptoms (e.g., dizziness, palpitations) before and during the NLT were recorded. Two hundred seventy‐seven long covid patients and 50 frequency‐matched healthy volunteers were tested. Healthy volunteers had no history of OI symptoms or symptoms during NLT or PoTS, 10% had asymptomatic OH. One hundred thirty (47%) long covid patients had previous history of OI symptoms and 144 (52%) developed symptoms during the NLT. Forty‐one (15%) had an abnormal NLT, 20 (7%) met criteria for PoTS, and 21 (8%) had OH. Of patients with an abnormal NLT, 45% had no prior symptoms of OI. Relaxing the diagnostic thresholds for PoTS from two consecutive abnormal readings to one abnormal reading during the NLT, resulted in 11% of long covid participants (an additional 4%) meeting criteria for PoTS, but not in healthy volunteers. More than half of long covid patients experienced OI symptoms during NLT and more than one in 10 patients met the criteria for either PoTS or OH, half of whom did not report previous typical OI symptoms. We therefore recommend all patients attending long covid clinics are offered an NLT and appropriate management commenced.

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