Autonomic dysreflexia in a mouse model of spinal cord injury

Jacob, Jasmine; Pniak, Anna; Weaver, Lynne C.; Brown, Arthur

doi:10.1016/s0306-4522(01)00436-5

Cited by 41 publications

(23 citation statements)

References 37 publications

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“…In developing embryos, motor axons extend from the spinal cord, grow into the limbs, and innervate targeted muscles (Jacob et al, 2001). The process of motor axon outgrowth and pathfinding is controlled by a combination of different factors (Schneider and Granato, 2003), for example, by members of the Eph/ephrins family of molecules (Eberhart et al, 2000) and by NCAM (Landmesser, 1996;Stoker, 1996).…”

Section: Expression Of the Adams By Motor Neuronsmentioning

confidence: 99%

Expression of seven members of the ADAM family in developing chicken spinal cord

Lin

Yan

Markus

et al. 2010

Developmental Dynamics

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The expression patterns of seven members of the ADAM (a disintegrin and metalloprotease) family, including ADAM9, ADAM10, ADAM12, ADAM13, ADAM17, ADAM22, and ADAM23, were analyzed in the developing chicken lumbar spinal cord by in situ hybridization and immunohistochemistry. Results show that each individual ADAM is expressed and regulated spatiotemporally in the lumbar cord and its surrounding tissues. ADAM9, ADAM10, ADAM22, and ADAM23 are expressed predominantly by motoneurons in the motor column and by sensory neurons in the dorsal root ganglia, each with a different expression pattern. ADAM12 and ADAM13 are mainly expressed in the meninges around the lumbar cord and in the condensed sheets of chondroblasts around the vertebrae. ADAM17 expression is strong in the ventricular layer and limited to early stages. The differential expression of the ADAMs in the lumbar cord suggests that the ADAMs play a regulatory role in development of the spinal cord. Developmental Dynamics 239:1246-1254,

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Section: Expression Of the Adams By Motor Neuronsmentioning

confidence: 99%

Expression of seven members of the ADAM family in developing chicken spinal cord

Lin

Yan

Markus

et al. 2010

Developmental Dynamics

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“…It has recently been demonstrated in animals that the development and severity of AD can be significantly attenuated by administering neuroprotective strategies acutely after spinal injury. 32,33 Additionally, it is known that sprouting of primary afferent fibers after SCI is part of the mechanism underlying the development of AD in rodents [34][35][36][37][38] and that administering anti-nerve growth factor (NGF) intraspinally can block AD. 39 Very recently, it was further demonstrated that adenoviraloverexpression of NGF (growth-promoting) or semaphorin 3A (Sema3a, growth-inhibiting), intraspinally, increased or decreased the postinjury sprouting of primary afferent fibers caudal to the lesion, respectively.…”

Section: Improving Sexual Function Is Important Irrespective Of Multmentioning

confidence: 99%

The impact of spinal cord injury on sexual function: concerns of the general population

et al. 2006

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Study Design: Secure, web-based survey. Objectives: Obtain information from the spinal cord injured (SCI) population regarding sexual dysfunctions, with the aim of developing new basic science and clinical research and eventual therapies targeting these issues. Setting: Worldwide web. Methods: Individuals 18 years or older living with SCI. Participants obtained a pass-code to enter a secure website and answered survey questions. A total of 286 subjects completed the survey. Results: The majority of participants stated that their SCI altered their sexual sense of self and that improving their sexual function would improve their quality of life (QoL). The primary reason for pursuing sexual activity was for intimacy need, not fertility. Bladder and bowel concerns during sexual activity were not strong enough to deter the majority of the population from engaging in sexual activity. However, in the subset of individuals concerned about bladder and/or bowel incontinence during sexual activity, this was a highly significant issue. In addition, the occurrence of autonomic dysreflexia (AD) during typical bladder or bowel care was a significant variable predicting the occurrence and distress of AD during sexual activity. Conclusion: Sexual function and its resultant impact on QoL is a major issue to an overwhelming majority of people living with SCI. This certainly constitutes the need for expanding research in multiple aspects to develop future therapeutic interventions for sexual health and SCI.

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“…19 Many biochemical changes and gene-regulated processes found at the sublesional level could be involved in motor recovery. For instance, the return of some functions and reflexes may be influenced by the sprouting of primary afferent fibers 22 and propriospinal neurons 23 or by increased glycinergic and gabaergic inhibition. 24 To examine higher levels of functional recovery such as after regeneration and reconnection across the lesion (ie, induced by grafts or drug treatments), it may be best to combine methods that are specifically designed to assess basic or fine locomotor movements (BBB, gridwalking, foot-print, etc).…”

Section: -13mentioning

confidence: 99%

Semiquantitative assessment of hindlimb movement recovery without intervention in adult paraplegic mice

Guertin

2004

Spinal Cord

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Study design: Experimental laboratory investigation of hindlimb movement recovery in chronic paraplegic mice. Objectives: Development of an assessment method to discriminatively quantify motor and locomotor-like movements of paraplegic mice. Setting: Laval University Medical Center, Quebec, Canada. Methods: Signs of 'functional recovery' were examined in open-field condition during 1 month in adult mice with a complete spinal cord transection at the low-thoracic level. Results: None of the mice exhibited hindlimb movements after spinalization. At 7 days, 33% of them displayed weak nonbilaterally alternating movements (NBA). At 14 days, increased NBA were observed and the first bilaterally alternating movements (BA) in 10% of the mice. A progressive increase of movement frequency and amplitude was found after 2-3 weeks. By the end of the month, 86% displayed mixed NBA and BA. However, none of them recovered the ability to stand or bear their own weight with the hindlimbs. Conclusion: This study reports signs of partial hindlimb movement recovery in chronic paraplegic mice and provides evidence of plasticity in sublesional circuits of neurons occurring in the absence of inputs from the brain, locomotor training or pharmacological treatment. This assessment method can be used to characterize hindlimb movements in complete spinal cord transected mice tested in open-field condition.

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Autonomic dysreflexia in a mouse model of spinal cord injury

Cited by 41 publications

References 37 publications

Expression of seven members of the ADAM family in developing chicken spinal cord

Expression of seven members of the ADAM family in developing chicken spinal cord

The impact of spinal cord injury on sexual function: concerns of the general population

Semiquantitative assessment of hindlimb movement recovery without intervention in adult paraplegic mice

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