Autonomic dysfunction of overweight combined with low muscle mass

Background: Attention deficit/hyperactivity disorder (ADHD) is a common childhood neuropsychiatric disorder. Autonomic nervous system plays a vital role in attention, self-regulation, emotional stability and social affiliation, which are affected in ADHD. The prefrontal cortex, which is vital for attention, motor control, emotional regulation and higher order autonomic control, is hypofunctional in ADHD. In addition, catecholamine dysregulation is there. Purpose: We hypothesized that there is autonomic dysfunction: reduction in overall heart rate variability (HRV) and sympathovagal imbalance in children with ADHD. Methods: Study criteria were drug-naïve ADHD children who were 7-12 years of age of either gender who fulfilled DSM-IV criteria for ADHD and did not have any associated comorbid psychiatric/neurological/medical disorders. Two hundred and seventy ADHD children were screened out of which only 12 were found eligible and 10 participated. Sample size was 20 (cases = 10, age- and gender-matched healthy controls = 10). Short-term HRV of both time and frequency domains were assessed by recording lead II electrocardiogram after using Tell-Show-Do, a behavior shaping technique. Comparison between groups was done using Mann-Whitney and Wilcoxon test. Demographic variables like age, height, weight and body mass index were similar between groups. Results: Among time domain parameters, SD of all NN intervals, square root of the mean of the sum of squares of differences between adjacent NN intervals and percentage of count of number of pairs of adjacent NN intervals differing by more than 50 ms were reduced in ADHD group with p < 0.05. Among frequency domain parameters, total power was reduced in ADHD group with p < 0.05, high frequency power (HF) was reduced in ADHD group with p < 0.01 and low frequency power to HF ratio was higher in ADHD group with p < 0.01. Conclusion: There is autonomic dysfunction in children with ADHD - reduction in overall HRV with sympathovagal imbalance with sympathetic dominance.

show abstract

“…This is supported by a study carried out by Baek et al [34] which shows that SDNN, RMSSD and HF are reduced in individuals with high BMI.…”

Section: Discussionsupporting

confidence: 74%

Heart Rate Variability in Children with Attention-Deficit/Hyperactivity Disorder: A Pilot Study

Rukmani¹,

Seshadri²,

Thennarasu

et al. 2016

Ann Neurosci

View full text Add to dashboard Cite

show abstract

“…But there is no definite study that showed that isolated grip strength was associated with abnormal HRV. Recent studies showed that muscle mass in obese patients is more likely to be related to HRV (34). Our study also found that lower muscle mass (lower than 25%) was related to HRV (OR, 95%CI; 0.92, 0.89-0.95) in obese but not in healthy individuals.…”

Section: The Relation Between Hrv and Isolated Low Grip Strengthsupporting

confidence: 71%

Obesity combined with low grip strength is correlated with cardiac autonomic nervous function in the Chinese elderly-an observational study

Shao

Guo

et al. 2019

Preprint

View full text Add to dashboard Cite

Background: Heart rate variability (HRV) provides indices related to all types of risks for death, increased risk of cardiovascular disease and diabetes, especially in elderly. Obesity and grip are related to diseases, thus decrease elderly healthy life. However, there is no definitive link between HRV and muscle strength and obesity. We conducted a cross-sectional study to determine whether grip strength and obesity are associated with HRV in elderly, community-dwelling Chinese individuals.Method: Our study population consisted of residents of Township Central Hospital of Chadian, Tianjin, China. We measured short term HRV, grip strength, and body mass index (BMI). The HRV measures were transformed to the natural log to normalize the distribution and we used logistic regression to explore the relationship.Results: A total of 534 participants over the age of 60 (200 men, mean age 69.2±6.0) had complete data at the baseline and were included in the analysis. Compared with the isolated-obesity group and isolated-low-grip-strength group, the group with concurrent obesity and low grip strength has a stronger relation with LF n.u.[0.94(0.90-0.98)], ln(LF) [0.50(0.29-0.95)], and ln(LF/HF) [0.41(0.20-0.83)].Conclusion: Our results demonstrate that low HRV is associated with concurrent low grip strength and obesity in older adults, rather than isolated low grip strength or isolated obesity. These results may provide a reference for early screening of cardiac autonomic function disorders in patients with potential heart disease in clinic, thus contributing indirectly to the prevention or rehabilitation of cardiovascular disease. It also provides a new idea for further mechanism research.Clinical trial registry Our research was registered on Research Registry website (URL: http://www.chictr.org.cn/index.aspx ), the registry number was ChiCTR1800016308.

show abstract

“…Although many studies have shown changes in HRV in athletes and physically active people 33 , few studies have linked these findings to the composition of muscle mass. Some authors have found that HRV in overweight patients is lower when it is associated with reduced muscle mass 34 , while other authors have shown that anthropometric behavior contributes to changes in the HRV 35 . A small sample of individuals was used because this was considered a pilot study; the sample should be expanded to validate the equations.…”

mentioning

confidence: 99%

Heart Rate Variability and Body Composition as Vo2max Determinants

León-Ariza

Botero‐Rosas

Zea-Robles

2017

Rev Bras Med Esporte

View full text Add to dashboard Cite

Introduction: The maximum oxygen consumption (VO 2max ) is the gold standard in the cardiorespiratory endurance assessment. Objective: This study aimed to develop a mathematical model that contains variables to determine the VO 2max of sedentary people. Methods: Twenty participants (10 men and 10 women) with a mean age of 19.8±1.77 years were included. For each participant, body composition (percentage of fat and muscle), heart rate variability (HRV) at rest (supine and standing), and VO 2max were evaluated through an indirect test on a cycloergometer. A multivariate linear regression model was developed from the data obtained, and the model assumptions were verified. The obtained model demonstrated the influence exerted by body composition, the autonomic nervous system, and age in the prediction of VO 2max.

show abstract

Autonomic dysfunction of overweight combined with low muscle mass

Abstract: This study suggests that HRV is reduced in overweight combined with low muscle mass group than overweight and HMM group.

Cited by 18 publications

References 27 publications

Heart Rate Variability in Children with Attention-Deficit/Hyperactivity Disorder: A Pilot Study

Heart Rate Variability in Children with Attention-Deficit/Hyperactivity Disorder: A Pilot Study

Obesity combined with low grip strength is correlated with cardiac autonomic nervous function in the Chinese elderly-an observational study

Heart Rate Variability and Body Composition as Vo2max Determinants

Contact Info

Product

Resources

About