Autonomic Dysfunction in the Synucleinopathies

Coon, Elizabeth A.

doi:10.1055/s-0040-1713844

Cited by 19 publications

(35 citation statements)

References 97 publications

(101 reference statements)

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“…Cardiovascular impairment, gastrointestinal dysfunction, and urinary disturbance are some of the key features of autonomic dysfunction in PD. 1 Orthostatic hypotension (OH), which is defined as a sustained drop in systolic blood pressure >20 mm Hg and/or a drop in diastolic blood pressure >10 mm Hg within 3 minutes from supine to standing, causes considerable limitations and impairment in quality of life. 2 OH may be neurogenic or non-neurogenic.…”

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confidence: 99%

Orthostatic Hypotension in Parkinson Disease

Lamotte

Lenka

2022

Neur Clin Pract

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Purposeof the review: Orthostatic hypotension (OH) is the primary manifestation of cardiovascular autonomic dysfunction in Parkinson’s disease (PD) and can be a prodromal feature of the disease. We review the recent progress in the field of autonomic dysfunction in PD.Recent findings:Individuals with isolated neurogenic OH should be followed up frequently as they may evolve into PD, dementia with Lewy bodies, or multiple system atrophy. The prevalence of OH in PD increases with disease stages but the role of levodopa remains unclear. Measurement of supine and standing heart rate and blood pressure allows for accurate identification of neurogenic OH in the clinic.Summary:Accurate identification of neurogenic OH in the clinic is crucial for identification of individuals who may benefit from participation in neuroprotective trials in the future. The treatment of OH in PD should be individualized and may reduce the risk of falls, cognitive impairment, and death.

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confidence: 99%

Orthostatic Hypotension in Parkinson Disease

Lamotte

Lenka

2022

Neur Clin Pract

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“…Patients with Parkinson’s disease may also have difficulty maintaining core temperature and can develop hypothermia, due to median preoptic lesions. [ 21 ] However, a description of the most characteristic and conspicuous signs and symptoms of Parkinson’s disease (e.g., bradykinesia, rest tremor, or rigidity) and DLB (e.g., recurrent visual hallucinations or REM sleep behavior disorder) is missing from the biblical text, thus seriously weakening the case for the diagnostic hypothesis of synucleinopathy.…”

Section: Edical H Ypothesis : H ...mentioning

confidence: 99%

Impaired Decision-Making Capacity in the Elderly King David (c. 1040–970 BCE)

Mendlowicz¹,

Mendlowicz²,

Ribeiro³

et al. 2023

Annals of Indian Academy of Neurology

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It has been suggested in the medical literature that in the last period of his life King David (c. 1040–970 BCE) suffered from dementia, osteoporosis, hyperparathyroidism, Parkinson’s disease, autonomic neuropathy, major depression, and malignancy. The goal of this study was to identify, based on the “Succession Narrative (SN),” a historically objective section of the Old Testament, the clinical syndrome presented by King David and to determine whether an impaired decision making capacity may have been manipulated by his courtiers to influence his succession’s politics. The “SN” indicates that besides forgetfulness and trouble in thinking, King David suffered from marked cold intolerance and sexual dysfunction. The symptom triad consisting of cognitive impairment, cold intolerance, and sexual dysfunction is more strongly suggestive of hypothyroidism than of any other diagnoses proposed in the medical literature so far. We hypothesized that hypothyroidism was the underlying cause of the elderly King David’s clinical picture and that his sometimes troubled thinking was successfully manipulated by the courtiers to favor his son Solomon’s accession to the throne, with profound historical consequences.

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“…Unlike PD, DLB, and MSA, Pure autonomic failure (PAF) is a rare sporadic neurodegenerative disease induced by dysfunction of autonomic nervous system (Thaisetthawatkul, 2016). It is slowly progressive disease and caused by abnormal accumulation of α-syn (Thaisetthawatkul, 2016;Coon et al, 2019;Coon, 2020). PAF patients showed orthostatic hypotension, syncope, falls, sexual and bladder dysfunction, and constipation with no motor dysfunction (Stubendorff et al, 2012;Allan, 2019).…”

Section: Paf (Pure Autonomic Failure)mentioning

confidence: 99%

The Role of Glial Mitochondria in α-Synuclein Toxicity

Jeon

Kwon

et al. 2020

Front. Cell Dev. Biol.

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The abnormal accumulation of alpha-synuclein (α-syn) aggregates in neurons and glial cells is widely known to be associated with many neurodegenerative diseases, including Parkinson’s disease (PD), Dementia with Lewy bodies (DLB), and Multiple system atrophy (MSA). Mitochondrial dysfunction in neurons and glia is known as a key feature of α-syn toxicity. Studies aimed at understanding α-syn-induced toxicity and its role in neurodegenerative diseases have primarily focused on neurons. However, a growing body of evidence demonstrates that glial cells such as microglia and astrocytes have been implicated in the initial pathogenesis and the progression of α-Synucleinopathy. Glial cells are important for supporting neuronal survival, synaptic functions, and local immunity. Furthermore, recent studies highlight the role of mitochondrial metabolism in the normal function of glial cells. In this work, we review the complex relationship between glial mitochondria and α-syn-mediated neurodegeneration, which may provide novel insights into the roles of glial cells in α-syn-associated neurodegenerative diseases.

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Autonomic Dysfunction in the Synucleinopathies

Cited by 19 publications

References 97 publications

Orthostatic Hypotension in Parkinson Disease

Orthostatic Hypotension in Parkinson Disease

Impaired Decision-Making Capacity in the Elderly King David (c. 1040–970 BCE)

The Role of Glial Mitochondria in α-Synuclein Toxicity

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