Autonomic dysfunction in patients with multiple sclerosis

Rakhmatullin, A R; Бахтиярова, К З; Magzhanov, R. V.

doi:10.17116/jnevro20171171155-58

Cited by 2 publications

(2 citation statements)

References 19 publications

(16 reference statements)

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“…The function of the sympathetic nervous system is usually corresponded to the LF-domain [20,21]. Many authors report on the decreased LF-band in MS patients and relate this to the reduced sympathetic control [3,11,26]. Activity of the sympathetic nervous system could be directly evaluated by the sudomotor function with help of SSR assessment [7,15,27].…”

Section: Discussionmentioning

confidence: 99%

Evidence of Autonomic Dysfunction in Patients with Relapsing-Remitting Multiple Sclerosis: Heart Rate Variability and Cardiovascular Parameters

2021

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This study was aimed at evaluation of autonomic dysfunction in patients with multiple sclerosis (MS) by means of time- and frequency-domain parameters of heart rate variability (HRV) and conventional cardiovascular tests (deep breathing (DB) and active orthostatic test (AOT)). The study group enrolled 32 patients with the relapsing-remitting MS (17 m, 15 f, aged 29 ± 4.9 years, disease duration 4.2 ± 2.7 years, EDSS scores less than 3.0 and 26 subjects in good health (HC, 15 m, 11 f, aged 30.1 ± 2.7 years). In the MS group, at rest the variability of heart rate was decreased in comparison to the HC group seen by time- (SDNN, RMSSD, pNN50, CV, p < 0.01) and frequency-domain (TP, HF, LF, p < 0.05) parameters, what was indicative of the general decrease of the autonomic neurogenic control of the heart rate, both sympathetic and parasympathetic. The functional tests (DB and AOT) showed reduced cardiovascular reactivity in the MS group. Additionally, the cardio-respiratory synchronization was impaired in the MS group at rest and DB. The severity of HRV deficit in the MS group correlated with the activity of MS. In conclusion, the comprehensive assessment of time- and frequency-domain HRV parameters studied with functional tests provides better insight to understanding autonomic dysfunction in subjects with relapsing-remitting MS.

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Section: Discussionmentioning

confidence: 99%

Evidence of Autonomic Dysfunction in Patients with Relapsing-Remitting Multiple Sclerosis: Heart Rate Variability and Cardiovascular Parameters

2021

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“…By the severity of the syndrome: the sum of points in the range of 25-30 corresponded to weak severity; 31-35 points -moderate; over 35 -a severe degree of Autonomic dysfunction syndrome (Magzhanov, 2017;Korchounov et al, 2005).…”

Section: Assessment Of Autonomic Disordersmentioning

confidence: 99%

Rehabilitation of COVID-19 Patients with Cognitive, Autonomic and Insomnia Disorders Using Medicinal Leech Therapy

SERİKBAYEVA,

ORMANOV,

ORMANOV

et al. 2023

Bütünleyici Ve Anadolu Tıbbı Dergisi

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New coronaNew coronavirus disease (COVID-19) pandemic is a historical and urgent issue worldwide. The long-term consequences of the disease are neurological disorders, which need further investigation in terms of treatment and prevention. Apart from the traditional medical approach, management of cognitive, autonomic and sleep complications may be rehabilitated using medicinal leeches. The purpose of this study is to compare the neurological condition of COVID-19 patients before and after hirudotherapy. This cross-sectional study was conducted from January to December 2021 at the medical centre of the Khoja Akhmet Yassawi International Kazakh-Turkish University. The research population consisted of 83 patients with mild and severe forms of COVID-19 (more than 6 months), who underwent medicinal leech therapy (MLT). MLT was applied to the patients on the 6th and 11th days and their assessment of cognitive, autonomic and sleep disorders were carried out. Statistical analysis was carried out using SPSS Statistics (version 20.0, IBM, USA). The results of studies indicate a progressive neurological deterioration in COVID-19 patients. Neuropsychological observations in patients taking a full course of MLT showed an objective improvement in their cognitive, autonomic and sleep disorders. In particular, the Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), Montreal Cognitive Assessment (MoCA) Scale, Schulte Tables, Spielberger-Khanin Anxiety Scale (SKAS), Beck depression inventory (BDI), Study scheme to identify signs of autonomic disorders, Epworth Sleepiness Scale (ESS), Index of Severity of Sleep Disorders (ISSD) values improved after the MLT procedures.

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Autonomic dysfunction in patients with multiple sclerosis

Abstract: The use of the Scheme is preferable in outpatient clinics to screen the large numbers of patients with MS, and then selected patients could be referred to the instrumental methods of investigation.

Cited by 2 publications

References 19 publications

Evidence of Autonomic Dysfunction in Patients with Relapsing-Remitting Multiple Sclerosis: Heart Rate Variability and Cardiovascular Parameters

Evidence of Autonomic Dysfunction in Patients with Relapsing-Remitting Multiple Sclerosis: Heart Rate Variability and Cardiovascular Parameters

Rehabilitation of COVID-19 Patients with Cognitive, Autonomic and Insomnia Disorders Using Medicinal Leech Therapy

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