Autonomic dysfunction and cardiovascular risk in post-traumatic stress disorder

Fu, Qi

doi:10.1016/j.autneu.2021.102923

Cited by 22 publications

(6 citation statements)

References 111 publications

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Section: Resultsmentioning

confidence: 99%

“…Prior work by our group demonstrated that pre-deployed warfighter dysautonomia is predictive of eventual development of post-traumatic stress disorder (PTSD) in servicemembers 66 . Because PTSD is known to have a baseline hyper-sympathetic drive, it is concordantly co-morbid with cardiac disease risk 67 . Therefore, it was postulated that the hyper-sympathetic timed respiratory challenge response identified in the CPTi group may indicate a biotype at risk for mental health disorder and or hyperinflammatory response.…”

Section: Discussionmentioning

confidence: 99%

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Measurement of Cervical Neuronal Activity during Stress Challenge Using Novel Flexible Adhesive Surface Electrodes

Kurniawa

Prince

et al. 2022

Preprint

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This study introduces a flexible, adhesive-integrated electrode array that was developed to enable non-invasive monitoring of cervical nerve activity. The device uses silver-silver chloride as the electrode material of choice and combines it with a novel electrode array consisting of a customized biopotential data acquisition unit and integrated graphical user interface (GUI) for visualization of real-time monitoring. Preliminary testing demonstrated this novel electrode design can achieve a high signal to noise ratio during cervical neural recordings. To demonstrate the capability of the surface electrodes to detect changes in cervical neuronal activity, the cold-pressor test (CPT) and a timed respiratory challenge were employed as stressors to the autonomic nervous system. This sensor system recording, a new novel technique, was termed Cervical Electroneurography (CEN). By applying a custom spike sorting algorithm to the novel electrode measurements, neural activity was classified in two ways: 1) pre-to-post CPT, and 2) during a timed respiratory challenge. Unique to this work: 1) rostral to caudal channel position-specific (cephalad to caudal) firing patterns and 2) cross challenge biotype-specific change in average CEN firing, were observed with both CPT and the timed respiratory challenge. Future work is planned to develop an ambulatory CEN recording device that could provide immediate notification of autonomic nervous system activity changes that might indicate autonomic dysregulation in healthy subjects and clinical disease states.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Measurement of Cervical Neuronal Activity during Stress Challenge Using Novel Flexible Adhesive Surface Electrodes

Kurniawa

Prince

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Prior work by our group demonstrated that pre-deployed warfighter dysautonomia is predictive of eventual development of post-traumatic stress disorder (PTSD) in servicemembers 79 . Because PTSD is known to have a baseline hyper-sympathetic drive, it is concordantly co-morbid with cardiac disease risk 80 . Therefore, it was postulated that the hyper-sympathetic timed respiratory challenge response identified in the CPTi group may indicate a biotype at risk for mental health disorder and or hyperinflammatory response.…”

Section: Discussionmentioning

confidence: 99%

A flexible adhesive surface electrode array capable of cervical electroneurography during a sequential autonomic stress challenge

Kurniawan

Prince

et al. 2022

Sci Rep

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This study introduces a flexible, adhesive-integrated electrode array that was developed to enable non-invasive monitoring of cervical nerve activity. The device uses silver-silver chloride as the electrode material of choice and combines it with an electrode array consisting of a customized biopotential data acquisition unit and integrated graphical user interface (GUI) for visualization of real-time monitoring. Preliminary testing demonstrated this electrode design can achieve a high signal to noise ratio during cervical neural recordings. To demonstrate the capability of the surface electrodes to detect changes in cervical neuronal activity, the cold-pressor test (CPT) and a timed respiratory challenge were employed as stressors to the autonomic nervous system. This sensor system recording, a new technique, was termed Cervical Electroneurography (CEN). By applying a custom spike sorting algorithm to the electrode measurements, neural activity was classified in two ways: (1) pre-to-post CPT, and (2) during a timed respiratory challenge. Unique to this work: (1) rostral to caudal channel position-specific (cephalad to caudal) firing patterns and (2) cross challenge biotype-specific change in average CEN firing, were observed with both CPT and the timed respiratory challenge. Future work is planned to develop an ambulatory CEN recording device that could provide immediate notification of autonomic nervous system activity changes that might indicate autonomic dysregulation in healthy subjects and clinical disease states.

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“…PTSD can increase the risk for cardiovascular disease, in part, via autonomic imbalance (Kim et al., 2019) and has been associated with decreased cortisol and higher blood pressure (BP) and BP variability outside of pregnancy (Fu, 2022). However, there is a dearth of data examining these cardiovascular parameters in pregnancy.…”

mentioning

confidence: 99%

Posttraumatic stress disorder, diurnal cortisol, and ambulatory blood pressure in early and late pregnancy

Bublitz

Nillni

Nugent

et al. 2022

Journal of Traumatic Stress

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Posttraumatic stress disorder (PTSD) affects 1 in 20 reproductive-aged women and is associated with cardiovascular disease morbidity and mortality. The pathophysiology linking PTSD to cardiovascular disease in nonpregnant adults is proposed to include hypothalamic and autonomic dysregulation; however, the pathways explaining this association in pregnancy are unclear. We examined diurnal cortisol and ambulatory blood pressure (BP) among 254 pregnant women at approximately 12 and 32 gestational weeks. Participants were, on average, 31 years old (SD = 5), 24.4% reported their ethnicity as Hispanic, and 62.2% reported their race as White. PTSD symptoms were measured using the PTSD Checklist for DSM-5 (PCL-5). Hierarchical linear regression analyses were performed to examine associations pregnancy between PTSD and cortisol at awakening, 30 min after awakening, and bedtime in early and late pregnancy, as well as associations between PTSD symptoms and daytime and nighttime systolic (SBP) and diastolic BP (DBP) and BP variability. Logistic regression analyses were conducted to test associations between PTSD symptoms and BP dipping. The results showed a positive association between PTSD symptoms and nighttime BP and BP variability at 32 gestational weeks, ∆R 2 = .036-.067. PTSD symptoms were negatively associated with awakening cortisol at 12 gestational weeks in unadjusted models. These findings contribute to understanding the associations between PTSD and adverse cardiovascular conditions in pregnancy. More research is needed to replicate these findings and examine whether PTSD interventions are effective at modifying pathways and decreasing the risk for cardiovascular complications in pregnancy.

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Autonomic dysfunction and cardiovascular risk in post-traumatic stress disorder

Cited by 22 publications

References 111 publications

Measurement of Cervical Neuronal Activity during Stress Challenge Using Novel Flexible Adhesive Surface Electrodes

Measurement of Cervical Neuronal Activity during Stress Challenge Using Novel Flexible Adhesive Surface Electrodes

A flexible adhesive surface electrode array capable of cervical electroneurography during a sequential autonomic stress challenge

Posttraumatic stress disorder, diurnal cortisol, and ambulatory blood pressure in early and late pregnancy

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