2011
DOI: 10.1007/s10286-011-0129-3
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Autonomic dysfunction affects cerebral neurovascular coupling

Abstract: These results demonstrate that cerebrovascular regulation is affected in FAP subjects with AF, and that it worsens with orthostasis.

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Cited by 41 publications
(31 citation statements)
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“…Of note, these same fTCD parameters are known to be disturbed in patients with vascular dementia, diabetes mellitus and migraine attacks [29,30,31]. Although it is plausible that these fTCD results are related to endothelial dysfunction, we cannot exclude an autonomic nervous system involvement in the cerebrovascular regulation, as shown in other diseases associated with autonomic failure [32]. …”
Section: Discussionmentioning
confidence: 99%
“…Of note, these same fTCD parameters are known to be disturbed in patients with vascular dementia, diabetes mellitus and migraine attacks [29,30,31]. Although it is plausible that these fTCD results are related to endothelial dysfunction, we cannot exclude an autonomic nervous system involvement in the cerebrovascular regulation, as shown in other diseases associated with autonomic failure [32]. …”
Section: Discussionmentioning
confidence: 99%
“…Both the P1 and P2 segments have been utilized with similar results, however a consistent segment should be maintained throughout a given study. 52,55,73,92,93 Lastly, often only the posterior window is suitable for insonating intracranial vessels in the elderly, due to skull thickening with advancing age. 94 Some studies have reported that 10À15% of individuals will have inadequate windows for insonating intracranial cerebral vessels; 95 as such, it may be advantageous to utilize other techniques such as NIRS (see next section) in addition to TCD for studies in the elderly or those with related cerebrovascular pathology.…”
Section: Transcranial Dopplermentioning
confidence: 99%
“…52 The selective activation of the occipital lobe is achieved using repeatable and reliable stimuli involving an eyes-open task against a bright visual stimuli (reading, flashing screen, eyes tracking tester's moving hand, etc.). The visual stimulation provides a strong mechanistic model of neurovascular coupling that is somewhat independent of variable neuronal activation schemes (i.e., a variety of different visual spatial tasks elicit similar PCA hyperemic responses); 73 however, less is understood about the hyperemia response in MCA or anterior cerebral arteries to tasks of varying difficulties or under different states of motivation. Conventionally, after a 10À15 min period of quiet rest (to allow stabilization of blood volume and hemodynamic signals), 5À10 cycles are repeated where each cycle consists of a 20À30 s period of eyes-closed time followed by 30À40 s of eyes-open time.…”
Section: Eliciting the Neurovascular Coupling Responsementioning
confidence: 99%
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“…Due to technical reasons the postural condition of the patients varies with these approaches. A recent focus on a disturbed NVC has been outlined in stroke [6], Alzheimer [7], and autonomic failure [8] diseases. For these reasons, a better understanding of NVC mechanism in different orthostatic conditions can have an impact both in scientific and clinical grounds.…”
Section: Introductionmentioning
confidence: 99%