Autonomic control and bariatric procedures

Zsombok, Andrea

doi:10.1016/j.autneu.2013.03.002

Cited by 2 publications

(4 citation statements)

References 66 publications

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“…The evaluation of BMI is considered a marker for the indication for surgery. In particular, this surgery is performed in subjects with a BMI > 40 kg/m 2 , in the absence of any other comorbidities and with BMI > 35 kg/m 2 with obesity-associated comorbidities [ 35 , 36 , 37 ].…”

Section: Bariatric Surgery: Why Is It Done and Who Is It For?mentioning

confidence: 99%

“…Bariatric surgery has many beneficial effects, but it has many serious risks and side effects [ 41 ]. Moreover, after bariatric surgery, a lifestyle change is necessary through healthy diet and regular physical activity making the beneficial effects of bariatric surgery last longer [ 36 ]. Among the beneficial effects of bariatric surgery is knowing that it increases weight loss and reduces the risk of obesity and its associated diseases.…”

Section: Bariatric Surgery: Why Is It Done and Who Is It For?mentioning

confidence: 99%

“…At the same time, BMI, also considered in its historical dimension as the maximum value reached by the patient, makes it possible to give indications for bariatric surgery. Finally, BMI is evaluated, together with metabolic, functional and psychological parameters, always in an overall balance between risks and benefits, in patients with a BMI > 40 kg/m 2 , in the absence of any other comorbidities; or with a BMI > 35 kg/m 2 , in the presence of comorbidities among those classically considered to be associated with obesity, including type 2 diabetes mellitus (T2DM) resistant to medical treatment [ 36 , 37 ].…”

Section: Bariatric Surgery: Why Is It Done and Who Is It For?mentioning

confidence: 99%

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The Metabolic Rearrangements of Bariatric Surgery: Focus on Orexin-A and the Adiponectin System

Valenzano

Tartaglia

Ambrosi

et al. 2020

JCM

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The accumulation of adipose tissue represents one of the characteristics of obesity, increasing the risk of developing correlated obesity diseases such as cardiovascular disease, type 2 diabetes, cancer, and immune diseases. Visceral adipose tissue accumulation leads to chronic low inflammation inducing an imbalanced adipokine secretion. Among these adipokines, Adiponectin is an important metabolic and inflammatory mediator. It is also known that adipose tissue is influenced by Orexin-A levels, a neuropeptide produced in the lateral hypothalamus. Adiponectin and Orexin-A are strongly decreased in obesity and are associated with metabolic and inflammatory pathways. The aim of this review was to investigate the involvement of the autonomic nervous system focusing on Adiponectin and Orexin-A after bariatric surgery. After bariatric surgery, Adiponectin and Orexin-A levels are strongly increased independently of weight loss showing that hormone increases are also attributable to a rearrangement of metabolic and inflammatory mediators. The restriction of food intake and malabsorption are not sufficient to clarify the clinical effects of bariatric surgery suggesting the involvement of neuro-hormonal feedback loops and also of mediators such as Adiponectin and Orexin-A.

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Section: Bariatric Surgery: Why Is It Done and Who Is It For?mentioning

confidence: 99%

Section: Bariatric Surgery: Why Is It Done and Who Is It For?mentioning

confidence: 99%

Section: Bariatric Surgery: Why Is It Done and Who Is It For?mentioning

confidence: 99%

See 1 more Smart Citation

The Metabolic Rearrangements of Bariatric Surgery: Focus on Orexin-A and the Adiponectin System

Valenzano

Tartaglia

Ambrosi

et al. 2020

JCM

View full text Add to dashboard Cite

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“…Activation of hepatic sympathetic innervation increases endogenous glucose production and glycogenolysis, whereas activation of the parasympathetic innervation decreases glucose production and promotes glucose storage (36,52,55,56,64). Hormones and nutrients, including glucose, leptin, and fatty acids, are also using the brain-liver pathway to regulate glucose homeostasis (28,37,40,41,46), and detailed information about the metabolic sensing, the neural innervation of the liver, or the autonomic control of hepatic lipid metabolism can be found in previous reviews (5,44,69,72).…”

Section: Control Of the Liver By Preautonomic Pvn Neurons: In Vivo Fimentioning

confidence: 99%

Brain-liver connections: role of the preautonomic PVN neurons

O’Hare

Zsombok

2016

American Journal of Physiology-Endocrinology and Metabolism

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O'Hare JD, Zsombok A. Brain-liver connections: role of the preautonomic PVN neurons. Am J Physiol Endocrinol Metab 310: E183-E189, 2016. First published December 8, 2015; doi:10.1152/ajpendo.00302.2015.-Diabetes mellitus and the coexisting conditions and complications, including hypo-and hyperglycemic events, obesity, high cholesterol levels, and many more, are devastating problems. Undoubtedly, there is a huge demand for treatment and prevention of these conditions that justifies the search for new approaches and concepts for better management of whole body metabolism. Emerging evidence demonstrates that the autonomic nervous system is largely involved in the regulation of glucose homeostasis; however, the underlying mechanisms are still under investigation. Within the hypothalamus, the paraventricular nucleus (PVN) is in a unique position to integrate neural and hormonal signals to command both the autonomic and neuroendocrine outflow. This minireview will provide a brief overview on the role of preautonomic PVN neurons and the importance of the PVN-liver pathway in the regulation of glucose homeostasis. paraventricular nucleus; liver-related neurons; glucose homeostasis DIABETES MELLITUS is the most common metabolic disorder. The National Diabetes Statistics Report from 2014 published by the Centers for Disease Control and Prevention (8a) estimated that 29.1 million people, which is 9.3% of the US population, suffer from diabetes mellitus. Even more alarming information is that the number of new diabetes cases showed an increase of 1.7 million within 2 yr, and in 2010 diabetes mellitus was listed as the seventh leading cause of death. The coexisting conditions and complications of diabetes mellitus are severe, including hypo-and hyperglycemic events, high blood pressure, obesity, high cholesterol levels, and many more. Undoubtedly, there is a huge demand for treatment and prevention of these conditions that justifies the search for new approaches and solutions for better management of whole body metabolism. One possibility, which has recently attracted more interest, is the role of the brain in the regulation of metabolism (46, 50), particularly the contribution of the autonomic nervous system (ANS) to metabolic control (51,69,73,75).The hypothalamus has been known as one of the critical brain structures that is involved in the regulation and coordination of homeostatic functions. Traditionally, the hypothalamus was appreciated for its neuroendocrine control system; however, its control over the ANS has also been recognized (17,46,51,69,75

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Autonomic control and bariatric procedures

Cited by 2 publications

References 66 publications

The Metabolic Rearrangements of Bariatric Surgery: Focus on Orexin-A and the Adiponectin System

The Metabolic Rearrangements of Bariatric Surgery: Focus on Orexin-A and the Adiponectin System

Brain-liver connections: role of the preautonomic PVN neurons

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