Autonomic changes in fibromyalgia: Clinical and electrophysiological study

Elsawy, Noha A; El-tantawi, G.; Achmawi, Ghada A.; Sultan, Hussein Al-Moghazy; Younis, Safaa

doi:10.1016/j.ajme.2012.02.007

Cited by 6 publications

(3 citation statements)

References 37 publications

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“…Given that SSR is controlled exclusively by sympathetic cholinergic terminals, these findings suggest increased sympathetic activity in FM patients. This result is in accordance with reports of increased SSR amplitudes in FM although other studies found lower amplitudes indicating decreased sympathetic activity [ 16 , 17 , 27 ]. These conflicting results between different studies may be explained by the well-known intra-individual variations for SSR testing, the significant heterogeneity in psychophysiological profiles among FM patients, and the influence of other confounders such as comorbidities and medications used [ 28 ].…”

Section: Discussionsupporting

confidence: 93%

Relationships of autonomic dysfunction with disease severity and neuropathic pain features in fibromyalgia: is it really a sympathetically maintained neuropathic pain?

Tanıgör

Baydar

2022

Korean J Pain

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Background: The pathophysiology of fibromyalgia (FM) involves many mechanisms including central nervous system sensitization theory, autonomic nervous system (ANS) dysfunction, and recently small fiber neuropathy. While the small fiber neuropathy itself can cause ANS dysfunction and neuropathic pain (NP), it is still unknown whether ANS problems have an association with severity of disease and NP in patients with FM. The aim of this study was to evaluate ANS dysfunction in FM patients and to explore possible associations of ANS dysfunction with disease severity and NP. Methods: Twenty-nine FM patients and 20 healthy controls were included in this cross-sectional study. Participants were tested using sympathetic skin responses (SSR) and R-R interval variation analyses for sympathetic and parasympathetic ANS dysfunction, respectively. Disease severity and somatic symptoms of patients with FM were evaluated using the ACR-2010 scales and Fibromyalgia Impact Questionnaire, and NP symptoms were evaluated using the Pain Detect Questionnaire and Douleur Neuropathique questionnaire. Results: FM patients were found to have ANS dysfunction characterized by increased sympathetic response and decreased parasympathetic response. SSR amplitudes were found to be correlated with a more severe disease. Although nonsignificant, NP severity tended to be associated with a decrease in sympathetic and parasympathetic activities. Conclusions: ANS dysfunction may play a role in the pathophysiology of FM. The trend of decreased ANS functions in FM patients exhibiting NP contradicts the notion that FM is a sympathetically maintained NP and may be explained with small fiber involvement.

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Section: Discussionsupporting

confidence: 93%

Relationships of autonomic dysfunction with disease severity and neuropathic pain features in fibromyalgia: is it really a sympathetically maintained neuropathic pain?

Tanıgör

Baydar

2022

Korean J Pain

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“…Solid tumors originating from transformed T-lymphocytes in the liver, spleen, gonads, lungs, kidneys, proventriculus, and heart are the typical finding in acute MD ( Chauhan et al, 2021 ; WOAH, 2023 ). The first case of MD was reported in Egypt in 1954 ( Soliman et al, 1954 ), and several studies, including pathological, virological, and/or seroepidemiological studies, have been published ( Sheble et al, 1973 ; El-Sawy et al, 1992 ; Amin et al, 2001 ; Awad, 2002 ; Hussein et al, 2004 ; Hassanin et al, 2013 ; Lebdah et al, 2017 ; El-Kenawy et al, 2019 ; Ewies et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Molecular characterization of Marek's Disease virus reveals reticuloendotheliosis virus-long terminal repeat integration in the genome of the field isolates in Egypt

Emad,

El-Kenawy,

El-Tholoth

2024

Poultry Science

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“…4 Increased pain may contribute to the dysfunction of the autonomic nervous system (ANS), which is considered one of the pathophysiological mechanisms for FM. 5 This dysfunction has been investigated through the analysis of heart rate variability (HRV), and there is scientific evidence of a good prognosis for both health and disease.…”

Section: Introductionmentioning

confidence: 99%

Pulsed Laser Acupuncture in the Treatment of Pain and Heart Rate Variability in Fibromyalgia Patients: A Pilot Randomized Clinical Trial

et al. 2022

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Introduction: Laser acupuncture (LA) is a medically approved treatment for chronic pain, especially fibromyalgia. It is widely known that all pain is related to autonomic modulation, which may influence heart rate variability (HRV). There are robust studies in the literature on the effect of LA with continuous frequency on musculoskeletal pain and autonomic modulation. However, little is known about the effect of pulsed frequency on fibromyalgia. Therefore, this study aimed to evaluate whether an individualized intervention protocol applying pulsed LA would provide benefits related to pain symptoms and cardiac autonomic modulation in patients with fibromyalgia. Methods: In this pilot randomized clinical controlled trial, the sample consisted of women with fibromyalgia between the ages of 40 and 80, randomized into two groups: a control group (CG; n=10) and an experimental group (EG; n=10). EG received the intervention twice per week for 3 weeks. Statistical analysis was conducted by delta (difference between post-intervention and pre-intervention) and the Shapiro-Wilk test (normality). For comparison between the groups, the Mann-Whitney test was used. Results: The results showed a significant reduction in pain intensity as reported via the pain numerical scale (PNS; P=0.00), generalized pain index (GPI; P=0.00), and symptom severity scale (SSS; P=0.00). There was no significant difference in any HRV variable (P>0.05). Conclusion: Pulsed LA, when applied in an individualized protocol, can reduce pain intensity, as reported on the PNS, GPI, and SSS. However, no therapeutic effect was observed for HRV.

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Autonomic changes in fibromyalgia: Clinical and electrophysiological study

Cited by 6 publications

References 37 publications

Relationships of autonomic dysfunction with disease severity and neuropathic pain features in fibromyalgia: is it really a sympathetically maintained neuropathic pain?

Relationships of autonomic dysfunction with disease severity and neuropathic pain features in fibromyalgia: is it really a sympathetically maintained neuropathic pain?

Molecular characterization of Marek's Disease virus reveals reticuloendotheliosis virus-long terminal repeat integration in the genome of the field isolates in Egypt

Pulsed Laser Acupuncture in the Treatment of Pain and Heart Rate Variability in Fibromyalgia Patients: A Pilot Randomized Clinical Trial

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