Autonomic brainstem nuclei are linked to the hippocampus

Castle, M.; Comoli, Eliane; Loewy, A.

doi:10.1016/j.neuroscience.2005.04.031

Cited by 118 publications

(88 citation statements)

References 67 publications

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“…As a part of trigeminovascular activation like migraine, TAC and epilepsy suggest the possibility of neuronal channelopathy. This association has been suggested also by a previous detailed experimental study [14].…”

Section: Discussionsupporting

confidence: 80%

Autonomic headache with autonomic seizures: a case report

2006

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The aim of the report is to present a case of an autonomic headache associated with autonomic seizures. A 19-year-old male who had had complex partial seizures for 15 years was admitted with autonomic complaints and left hemicranial headache, independent from seizures, that he had had for 2 years and were provoked by watching television. Brain magnetic resonance imaging showed right hippocampal sclerosis and electroencephalography revealed epileptic activity in right hemispheric areas. Treatment with valproic acid decreased the complaints. The headache did not fulfil the criteria for the diagnosis of trigeminal autonomic cephalalgias, and was different from epileptic headache, which was defined as a pressing type pain felt over the forehead for several minutes to a few hours. Although epileptic headache responds to anti-epileptics and the complaints of the present case decreased with antiepileptics, it has been suggested that the headache could be a nontrigeminal autonomic headache instead of an epileptic headache.

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Section: Discussionsupporting

confidence: 80%

Autonomic headache with autonomic seizures: a case report

2006

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“…This is the first such study in a population sample of both men and women detailed with information on co--medications and co--morbidities. Memory recall and language were most strongly associated with lower HRV values, suggesting implication of a common neuro--anatomical pathway, possibly the fornix, which is the predominant outflow tract of the hippocampus and functions in autonomic control [6]. The direction of causality will be explored in futures waves of this longitudinal study.…”

Section: Resultsmentioning

confidence: 89%

“…The integrity of the fornix, which is the predominant outflow tract of the hippocampus, is predictive of memory performance and progression from MCI to AD [19]. This region is also implicated in autonomic control [6], suggesting that the fornix may form the anatomical location underlying the relationship between HRV and cognition.…”

Section: Resultsmentioning

confidence: 99%

Cognitive function is associated with impaired heart rate variability in ageing adults: the Irish longitudinal study on ageing wave one results

Frewen¹,

Finucane

Savva³

et al. 2013

Clin Auton Res

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ObjectiveTo examine the independent association between heart rate variability (HRV) and cognitive performance, in a nationally representative population study of older adults. MethodsCross--sectional analysis of wave 1 data from the Irish longitudinal study on ageing (TILDA) was performed. A subset of 4,763 participants who underwent ECG recording during resting and paced breathing periods were used for the analysis. HRV indices were divided into quintiles for comparison of values and cognitive performance was defined using the Montreal cognitive assessment (MOCA) score. Multivariate linear regression was used to model the association between cognition and different quintiles of each HRV index, after adjustment for covariates. ResultsThe mean age was 61.7 ± 8.3 years and 2,618 (55 %) were female. Lower quintiles of SDNN (P = 0.01--paced), LF (P = 0.001--paced), and LF:HF ratio (P = 0.049--paced) were significantly associated with lower MOCA scores (during both recording periods), independent of confounders. Sub--domains of MOCA responsible for the relationship were predominantly memory recall and language. InterpretationReduced HRV is significantly associated with lower cognitive performance at a population level in people aged 50 and older. This further strengthens the relationship between autonomic dysfunction and cognitive disorders.

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“…The NTS also sends indirect projections widely throughout the brain that originate from its direct projections (Castle et al, 2005;Nemeroff et al, 2006). For example, a recent study using transneuronal tract tracing demonstrated that visceral afferents from the NTS may influence the ventral hippocampus through a circuit that includes the LC, thalamus, and BST (Castle et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Induction of c-Fos and ΔFosB Immunoreactivity in Rat Brain by Vagal Nerve Stimulation

Cunningham

Mifflin

Gould

et al. 2007

Neuropsychopharmacol

145

123

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Vagus nerve stimulation (VNS) is used as therapy for treatment-resistant depression or epilepsy. This study used immunohistochemistry for biomarkers of short-term (c-Fos) and long-term (DFosB) neuronal activation to map regions in brain that are activated by acute (2 h) or chronic (3 weeks) VNS in conscious Sprague-Dawley rats. Electrodes (Cyberonics Inc.) were implanted on the left vagus nerve and 1 week after surgery, stimulation began using parameters employed clinically (one burst of 20 Hz, 250 ms pulse width, 0.25 mA stimulation for 30 s every 5 min). Radio telemetry transmitters were used for monitoring blood pressure, heart rate, activity, and respiratory rate during VNS; neither acute nor chronic VNS significantly affected these parameters. Acute VNS significantly increased c-Fos staining in the nucleus of the solitary tract, paraventricular nucleus of the hypothalamus, parabrachial nucleus, ventral bed nucleus of the stria terminalis, and locus coeruleus but not in the cingulate cortex or dorsal raphe nucleus (DRN). Acute VNS did not affect DFosB staining in any region. Chronic VNS significantly increased DFosB and c-Fos staining bilaterally in each region affected by acute VNS as well as in the cingulate cortex and DRN. Using these stimulation parameters, VNS was tested for antidepressant-like activity using the forced swim test (FST). Both VNS and desipramine significantly decreased immobility in the FST; whereas desipramine decreased immobility by increasing climbing behavior, VNS did so by increasing swimming behavior. This study, then, identified potential sites in brain where VNS may produce its clinical effects.

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Autonomic brainstem nuclei are linked to the hippocampus

Cited by 118 publications

References 67 publications

Autonomic headache with autonomic seizures: a case report

Autonomic headache with autonomic seizures: a case report

Cognitive function is associated with impaired heart rate variability in ageing adults: the Irish longitudinal study on ageing wave one results

Induction of c-Fos and ΔFosB Immunoreactivity in Rat Brain by Vagal Nerve Stimulation

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