Autonomic balance revisited: Panic anxiety and heart rate variability

Friedman, Bruce H.; Thayer, Julian F.

doi:10.1016/s0022-3999(97)00202-x

Cited by 518 publications

(375 citation statements)

References 91 publications

Supporting

Mentioning

335

Contrasting

Unclassified

Order By: Relevance

“…Together with the observed lower HR variability in KO mice compared with WT mice, this might point to a ceiling effect of HR in KO mice, or alternatively to altered HR dynamics in KO mice. Interestingly, in mice subjected to a fear conditioning procedure also lower HR variability was found (Stiedl and Spiess 1997), and in humans a link has been proposed between low HR variability and risk for anxiety disorders (Friedman and Thayer 1998a). The strong tachycardic response found in KO mice was accompanied by a comparable higher increase in core BT of approximately 1ЊC over WT mice.…”

Section: Discussionmentioning

confidence: 90%

“…Mean BT, HR, and GA data were calculated over successive 1-min blocks for both genotypes. For HR, also heart rate variability (HRV), a parameter for autonomic control of heart rate (Friedman and Thayer 1998a; was computed as the mean standard deviation of HR (Stiedl and Spiess 1997). Data were analyzed by means of an ANOVA for repeated measures, with genotype as between-subjects factor, and BT, HR, and GA in 1-min blocks as within-subjects factor.…”

Section: Discussionmentioning

confidence: 99%

“…In humans, anxiety and stress disorders are often associated with autonomic nervous system changes and include tachycardia and heart palpitations (Friedman and Thayer 1998a) and elevated core body temperature (Lesch 1991;Murphy et al 1991). In animals, experimentally induced stress elicits tachycardia (Bouwknecht et al 2000;Nijsen et al 1998a) and increases body temperature (Borsini et al 1989;Bouwknecht et al 2000;Olivier et al 1998).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Autonomic Changes Associated with Enhanced Anxiety in 5-HT1A Receptor Knockout Mice

Pattij

Groenink

Hijzen

et al. 2002

Neuropsychopharmacology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Autonomic Changes Associated with Enhanced Anxiety in 5-HT1A Receptor Knockout Mice

Pattij

Groenink

Hijzen

et al. 2002

Neuropsychopharmacology

View full text Add to dashboard Cite

“…Patients with panic disorder have lower SDNN (31) and HF power (32) as well as a higher LF/HF ratio than controls (32). Many studies have reported that depression is associated with a lower resting HRV (See (33) for review) but it is unclear whether disruption in autonomic nervous system function is a trait or state marker for depression (34).…”

Section: Discussionmentioning

confidence: 99%

Reduced parasympathetic activity during sleep in the symptomatic phase of severe premenstrual syndrome

Baker

Colrain

Trinder

2008

Journal of Psychosomatic Research

View full text Add to dashboard Cite

Objective-Severe premenstrual syndrome (PMS) is a common, distressing disorder in women that manifests during the premenstrual (late-luteal) phase of the ovulatory menstrual cycle. There is some evidence that altered autonomic function may be an important component of PMS but few studies have used heart rate variability (HRV), as a sensitive marker of autonomic activity, in severe PMS and findings are conflicting.Methods-We investigated HRV during sleep, a state relatively free of external disruptions, in nine women with severe PMS and twelve controls.Results-The normal-to-normal (NN) RR-interval was shorter during the sleep period in women with PMS than in controls in both the follicular and late-luteal phases of the menstrual cycle. The standard deviation of all NN intervals (SDNN), a measure of total variability in the inter-beat interval, was lower during the sleep period in the late-luteal phase than in the follicular phase in women with PMS. The square root of the mean of the sum of the squares of differences between adjacent NN intervals (rMSSD), a measure reflecting high frequency activity, showed a similar pattern. High frequency power, a marker of parasympathetic activity, was lower during non-rapid eye movement (non-REM) and REM sleep in the late-luteal phase than in the follicular phase in women with severe PMS. Controls had a shorter NN-interval, but similar HRV measures, in the late-luteal phase compared with the follicular phase.Conclusion-These results suggest that women with severe PMS have decreased parasympathetic activity during sleep in association with their premenstrual symptoms compared to when they are symptom-free.

show abstract

“…Moreover, panic disorder patients seem to have impaired mechanisms of compensation to orthostasis [51][52]. Two classic articles articulating the catastrophic-cognition generation of panic describe the importance of orthostatically induced arousal and dizziness as triggers [53][54].…”

Section: Catastrophic Cognitions Regarding Orthostatic Dizziness-evenmentioning

confidence: 99%

Panic disorder among Vietnamese refugees attending a psychiatric clinic: prevalence and subtypes

Hinton

Chau

Nguyen

et al. 2001

General Hospital Psychiatry

View full text Add to dashboard Cite

This study surveys Vietnamese refugees attending two psychiatric clinics to determine both the prevalence of panic disorder (PD) as well as panic attack subtypes in those suffering PD. A culturally valid adaptation of the SCID-panic module (the Vietnamese Panic Disorder Survey or VPDS) was administered to 100 Vietnamese refugees attending two psychiatric clinics. Utilizing culturally sensitive panic probes, the VPDS provides information regarding both the presence of PD and panic attack subtypes during the month prior to interview. Of 100 patients surveyed, 50 (50%) currently suffered PD. Among the 50 patients suffering PD, the most common panic attack subtypes during the previous month were the following: "orthostatic dizziness" (74% of the 50 panic disorder patients [PDPs]), headache (50% of PDPs), wind-induced/temperature-shift-induced (24% of PDPs), effortinduced (18% of PDPs), gastro-intestinal (16% of PDPs), micturition-induced (8% of PDPs), outof-the-blue palpitations (24% of PDPs), and out-of-the-blue shortness of breath (16% of PDPs). Five mechanisms are adduced to account for this high PD prevalence as well as the specific profile of subtypes: 1) a trauma-caused panic attack diathesis; 2) trauma-event cues; 3) ethnic differences in physiology; 4) catastrophic cognitions generated by cultural syndromes; and 5) a modification of Clark's spiral of panic.

show abstract

Autonomic balance revisited: Panic anxiety and heart rate variability

Cited by 518 publications

References 91 publications

Autonomic Changes Associated with Enhanced Anxiety in 5-HT1A Receptor Knockout Mice

Autonomic Changes Associated with Enhanced Anxiety in 5-HT1A Receptor Knockout Mice

Reduced parasympathetic activity during sleep in the symptomatic phase of severe premenstrual syndrome

Panic disorder among Vietnamese refugees attending a psychiatric clinic: prevalence and subtypes

Contact Info

Product

Resources

About