Automédication par Annona muricata L. (corossol) à visée anticancéreuse à la Réunion

Moreau, David; Huchot, É.; Gazaille, V.; Rossanaly-Vasram, R.; Meynier, André

doi:10.1016/j.rmr.2018.08.001

Cited by 9 publications

(10 citation statements)

References 20 publications

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“…Moreau and al found that Annona muricata L. (corossol) was the most utilized herbal product (67%) followed by Curcuma longa L.(15%) by patients suffering from lung cancer in Reunion. 20 Our study showed that the entourage (family, friends, hospital entourage) is the main source of knowledge regarding CAM use (74.44%). This result is confirming a study which reviewed CAM use in breast cancer patients.…”

Section: Discussionmentioning

confidence: 66%

“…Significant inhibition of CYP activity (CYP2C9, 3A4 and CYP2D6) (IC50 < 10 mg/mL) significant inhibition of P-gp with IC50 value 24 AE 1 mg/mL 25 May cause hepatic toxicities the use of this plant is contraindicate in hypertensive patients, diabetics and in the chronic diseases of the liver and kidney. 20 The study of Lili Indrawati and al showed the safety of A. muricata leaves water extracton bone marrow, liver and kidney or Colorectal Cancer Patients In our survey, the majority of CAM users (61.11%) reported to consume CAM currently with conventional therapies.…”

Section: Annona Muricatamentioning

confidence: 62%

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Patterns of complementary and alternative medicine use among Tunisian cancer patients

Toukabri

Said

Hamdi

et al. 2020

J Oncol Pharm Pract

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Introduction The use of complementary and alternative medicine (CAM) among cancer patients is prevalent worldwide as cancer patient are perpetually seeking for a way to improve their quality of life and to cure their disease. Unfortunately, the majority ignore the danger that can resort when they use CAM currently with conventional therapies. The purpose of this study is to assess prevalence and predictors of CAM use in cancer patients. Methods Cross-sectional study using a questionnaire administered to cancer patients, who were attending Salah Azaiz institute, Tunis, Tunisia. The study took place from September to December 2018. Results In 222 cancer patients, the overall prevalence of CAM use was 40.54%. On univariate analysis, patients who had university education level were less likely to use CAM (p = 0.05). Based on multivariate analysis, CAM users had more likely metastatic tumor (p = 0.047; OR = 1.913).It is reported that the majority of the population used herbal medicine. The most common herbal products consuming by patients, included Ephedra foeminea (51.8%), Annona muricata (12%) and Curcuma longa L. (10.84%).The main source of information was entourage (family, friends, hospital entourage) (74.44%).The majority of CAM users (61.11%) reported to consume CAM currently with conventional therapies. Conclusion This survey revealed a high prevalence of CAM use. The most common type of CAM use is herbal products. Some of the used herbal products are known to interact with conventional anticancer medication. This emphasizes the importance of patients disclosure of CAM use to health professionals in order to avoid herb-medications interactions.

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Section: Discussionmentioning

confidence: 66%

Section: Annona Muricatamentioning

confidence: 62%

Patterns of complementary and alternative medicine use among Tunisian cancer patients

Toukabri

Said

Hamdi

et al. 2020

J Oncol Pharm Pract

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“…4 Previous findings revealed that A. muricata L. is a rich source of bioactive phenolic compounds with antidiabetic and antihypertensive potentials 5 and anticancerogenic properties. 6 Antioxidant activity and inhibition against ⊍-amylase, ⊍-glucosidase, and angiotensin-I converting enzyme (ACE) of A. muricata L. pericarp extract was also reported. 5 Unfortunately, the highly perishable nature of soursop fruit aggravated by the lack of appropriate post-harvest techniques leads to its post-harvest losses at about 76% of its total production.…”

Section: Introductionmentioning

confidence: 99%

“…The fruit is reported to be a good source of fibers, minerals [phosphorus (P), iron (Fe), and calcium (Ca)], vitamins (B1, B2, B3, and C) and amino acids [methionine (Met), lysine (Lys) and tryptophan (Trp)] 4 . Previous findings revealed that A. muricata L. is a rich source of bioactive phenolic compounds with antidiabetic and antihypertensive potentials 5 and anticancerogenic properties 6 . Antioxidant activity and inhibition against α ‐amylase, α ‐glucosidase, and angiotensin‐I converting enzyme (ACE) of A. muricata L. pericarp extract was also reported 5 .…”

Section: Introductionmentioning

confidence: 99%

Optimization of pectinase‐assisted extraction of Annona muricata L. juice and the effect of liquefaction on its pectin structure

et al. 2020

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BACKGROUND: Soursop (Annona muricata L.) is an underutilized tropical and subtropical fruit with high nutritional and therapeutic benefits. This fruit is faced with enormous post-harvest losses due to its high perishability. This work was aimed to optimize the pectinase-assisted extraction conditions of soursop juice using Doehlert design and to study the effect of pectinase on its pectin structure. RESULTS: The predicted models were validated for all the responses studied and the regression coefficients ranged from 0.905 to 0.987 (P ≤ 0.05). An incubation time of 172 min, enzyme concentration of 0.04% (w/w) and incubation temperature at 42.9°C were found to be the optimal conditions for soursop juice extraction, which resulted in 75.20%, 3.74, 7.35°Brix, 87.06%T, and 0.44% MAE for soursop juice yield (%), pH, total soluble solids (TSS) (°Brix), clarity (%T) and titratable acidity (% malic acid equivalent, MAE), respectively. Morphologically, untreated soursop pulp presented a non-uniform spherical surface; enzyme hydrolyzed soursop exhibited ruptured and wrinkled surface; meanwhile for the different pectin obtained, untreated soursop pectin depicted porous surface and enzyme hydrolyzed soursop pectin showed whirling rough surface. Fourier-transform infrared (FTIR) confirmed the presence of similar chemical group stretching and vibrations in commercial pectin and soursop pectin. CONCLUSION: Under the optimum conditions, the numerical predictions were similar to the experimental data obtained, thus confirming the validity of the models. Application of enzyme treatment caused the breakdown of pectin structure as illustrated by scanning electron microscopy (SEM) and FTIR analyses. Supporting information may be found in the online version of this article.

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“…Annona muricata (AM) (Graviola), This tropical tree from the Annonaceae family consists of evergreen dark green leaves and heart-shaped fruits [19]. It is very common to consume this fruit, which is called a 'cancer killer' by the local people in tropical regions, by boiling the leaves in the treatment of cancer [19,30]. In addition, AM, which contains many avonoids, alkaloids and acetogens in its leaves, is also used for the management of infections, diarrhea, dermatitis, diabetes, fever and cardiovascular problems [8].…”

Section: Introductionmentioning

confidence: 99%

The Neuroprotective and Anti-Inflammatory Effects of Annona Muricata (Graviola) on Radiation-Induced Rat Sciatic Nerve Injury.

Keskin¹,

Elmas²,

Şahin³

et al. 2021

Preprint

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Background: In radiotherapy (RT) exposure area, normal tissues are also affected that may cause serious complications in the patients. This study aimed to evaluate Annona muricata’s radioprotective effects on sciatic nerve injury due to ionizing radiation (IR). Methods and Results: 32 adult female Wistar albino rats separated into 4 equal groups; Control (C), Annona muricata leaf extracts (AME), radiation (RAD), radiation and Annona muricata leaf extracts (AME+RAD). In groups AME and AME+RAD, Annona muricata leaf extracts were administered at a dose of 300 mg/kg for the first day and 50 mg/kg everyday for following one week intraperitoneally. In RAD and AME+RAD, rats were exposed to a single dose of 20 Gray IR to their right legs. All the subjects were sacrified at the end of the first month. Oxidative stress biochemical parameters (SOD, CAT and GPx) from blood samples were analyzed. Right sciatic nerves extracted and histomorphology evaluated. Statistically significant vasculature, degenerative and necrotic changes were observed in RAD, compared to C and AME (p<0,01). Swelling in myelin sheath was predominantly seen in RAD. Alterations in the level of CAT (p<0,01), SOD (p<0,01) and GPx (p<0,05) in AME+RAD group compared to RAD group were found to be statistically significant.Conclusion: Our study unveiled that AM could have a potential of biochemically and histomorphology healing on sciatic nerve injury due to ionizing radiation.

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Automédication par Annona muricata L. (corossol) à visée anticancéreuse à la Réunion

Cited by 9 publications

References 20 publications

Patterns of complementary and alternative medicine use among Tunisian cancer patients

Patterns of complementary and alternative medicine use among Tunisian cancer patients

Optimization of pectinase‐assisted extraction of Annona muricata L. juice and the effect of liquefaction on its pectin structure

The Neuroprotective and Anti-Inflammatory Effects of Annona Muricata (Graviola) on Radiation-Induced Rat Sciatic Nerve Injury.

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