Automation to Enable High-Throughput Chemical Proteomics
Zongtao Lin,
Joanna Gongora,
Xingyu Liu
et al.
Abstract:Chemical proteomics utilizes small-molecule probes to
covalently
engage with their interacting proteins. Since chemical probes are
tagged to the active or binding sites of functional proteins, chemical
proteomics can be used to profile protein targets, reveal precise
binding sites/mechanisms, and screen inhibitors competing with probes
in a biological context. These capabilities of chemical proteomics
have great potential to enable discoveries of both drug targets and
lead compounds. However, chemical proteomi… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.