Automation synthesis modules review

Manual vs automated 68Ga‐radiolabelling—A comparison of optimized processes

“…Besides that, main advantages of automation are its higher reliability, better reproducibility, and time saving. This is also supported by the findings of other studies investigating automated radiolabelling …”

Preparation and evaluation of a single vial AMBA kit for 68Ga labeling with potential for imaging of GRP receptor-positive cancers

“…The well-established chemistry of 68 Ga enables formation of coordination complexes with suitable chelates conjugated to peptides [19,20]. The tremendous prospects associated with the 68 Ge/ 68 Ga generators and the challenge of providing 68 Ga amenable for use in the clinic led to considerable research efforts resulting in their commercial availability along with automated radiolabeling modules [20][21][22][23][24][25][26]. While these developments constitute a step in right direction, their exorbitant price tags emerged as major obstacles that continue to thwart efforts for widespread use.…”

Fully Automated Production of Diverse 18F-Labeled PET Tracers on the ELIXYS Multireactor Radiosynthesizer Without Hardware Modification

“…To support these PET studies, many fully-automated radiosynthesizers have been developed to aid radiochemists in routinely producing PET tracers ( 2 ). For [ 18 F]fluoride radiochemistry ( 3,4 ), these systems are typically based on either a fixed-tubing design, that requires cleaning after every synthesis run, or a disposable cassette approach ( 5,6 ). Some fixed-tubing systems can be modified to produce different tracers, though it can be difficult for operators to reconfigure both the tubing layout and software for new tracers.…”