Automaticity of Subsidiary Pacemakers of Patients with Dysfunction of the Sinus Node

Lien, Wen-Pin; Chen, Jin-Jer; Wu, Teh-Lu; Chang, Fu-Zen

doi:10.1378/chest.78.5.747

Chest

1980

DOI: 10.1378/chest.78.5.747

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Automaticity of Subsidiary Pacemakers of Patients with Dysfunction of the Sinus Node

Wen-Pin Lien

Jin-Jer Chen

Teh-Lu Wu

et al.

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1982

2005

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Cited by 6 publications

(1 citation statement)

References 31 publications

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“…Such a response might occur among patients with a diseased heart [28] or in the setting of drug intoxication [11], but seems very less likely among untreated young patients free from intrinsic, structural myocardial disease.…”

mentioning

confidence: 99%

Cardiac pacing in patients with familial dysautonomia

Bartoletti

2005

Clin Auton Res

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mentioning

confidence: 99%

Cardiac pacing in patients with familial dysautonomia

Bartoletti

2005

Clin Auton Res

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Alterations in subsidiary pacemaker function after prolonged subsidiary pacemaker dominance in the canine right atrium

Rozanski¹,

Lipsius²,

Randall³

et al. 1984

Journal of the American College of Cardiology

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In vivo and in vitro techniques were used to study the functional characteristics of subsidiary atrial pacemaker activity 4 to 11 months after surgical excision of the sinoatrial node region of the dog heart. Characteristics of this long-term subsidiary atrial pacemaker activity were compared with those of sinoatrial node and short-term subsidiary atrial pacemaker activities. Extracellular bipolar electrodes were used to estimate the site of earliest activation and monitor spontaneous rate. Under both in vivo and in vitro conditions, long-term pacemaker activity was located in the same region of the inferior right atrium as was short-term pacemaker activity. Under in vitro conditions, long-term activity was characterized by a reduced sensitivity to acetylcholine and overdrive pacing and by a lack of dependence on beta-adrenergic stimulation compared with short-term activity. Furthermore, long-term pacemaker activity was more sensitive to acetylcholine and less sensitive to norepinephrine (greater than 10(-7) M) compared with sinoatrial node activity. It is concluded that the subsidiary atrial pacemakers that emerge soon after removal of the sinoatrial node are the same as those pacemakers that ultimately assume long-term control of the heart. In addition, after subsidiary atrial pacemakers assume dominant pacemaker function, their dependence on norepinephrine and their response to acetylcholine and overdrive pacing are reduced. These changes facilitate a more stable regulation of atrial pacemaker rhythm and, thereby, make subsidiary atrial pacemaker function more like that of the sinoatrial node.

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Effect of atropine on escape mechanism of the subsidiary pacemakers in patients with dysfunction of the sinus node.

Lien¹,

Chen²,

Wu³

1982

Jpn Circ J

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Automaticity of Subsidiary Pacemakers of Patients with Dysfunction of the Sinus Node

Cited by 6 publications

References 31 publications

Cardiac pacing in patients with familial dysautonomia

Cardiac pacing in patients with familial dysautonomia

Alterations in subsidiary pacemaker function after prolonged subsidiary pacemaker dominance in the canine right atrium

Effect of atropine on escape mechanism of the subsidiary pacemakers in patients with dysfunction of the sinus node.

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