Automatic weak-current measurement system with high precision

Wang, Jing; Li, Binkang; Linbo, Ruan; Tian, Geng; Li, Xianbao; Hongguang, Qu

doi:10.3788/hplpb20122408.1975

Cited by 3 publications

(2 citation statements)

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“…The calculated currents for the four nucleotides and four orientation angles are shown in Figure , and the calculated values at 0.15 V are included in Table . Notice that for the ha -Sy with the nucleotides rotated by 0 and 90°, the ha -Sy + C shows the highest current, while with 180 and 270° such highest current corresponds to the ha -Sy + T. Note also that the measurement of very small values of current (nanoampere and picoampere) has been achieved and reported in previous works, − which implies that the obtained values of current and their differences shown in Table can be used to selectively discriminate between nucleobases and angles, especially at relatively large voltages.…”

Section: Resultsmentioning

confidence: 55%

Selective Sensing of DNA Nucleobases with Angular Discrimination

Algharagholy,

García-Suárez,

Abaas

2024

ACS Omega

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The fast and precise selective sensing of DNA nucleobases is a longpursued method that can lead to huge advances in the field of genomics and have an impact on aspects such as the prevention of diseases, health enhancement, and, in general, all types of medical treatments. We present here a new type of nanoscale sensor based on carbon nanotubes with a specific geometry that can discriminate the type of nucleobase and also its angle of orientation. The proper differentiation of nucleobases is essential to clearly sequence DNA chains, while angular discrimination is key to improving the sensing selectivity. We perform first-principle and quantum transport simulations to calculate the transmission, conductance, and current of the nanotube-based nanoscale sensor in the presence of the four nucleotides (A, C, G, and T), each of them rotated 0, 90, 180, or 270°. Our results show that this system is able to effectively discriminate between the four nucleotides and their angle of orientation. We explain these findings in terms of the interaction between the phosphate group of the nucleotide and the nanotube wall. The phosphate specifically distorts the electronic structure of the nanotube depending on the distance and the orientation and leads to nontrivial changes in the transmission. This work provides a method for finer and more precise sequential DNA chains.

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Section: Resultsmentioning

confidence: 55%

Selective Sensing of DNA Nucleobases with Angular Discrimination

Algharagholy,

García-Suárez,

Abaas

2024

ACS Omega

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show abstract

“…Table S2 † shows the obtained current values for all cases. Despite the fact that the differences between those values are small, previously published works [92][93][94][95][96][97] reported that the measurement of very small currents, including nanoamperes and picoamperes, can be achieved. This means that the resulting currents shown in Table S2 † and their differences can be used to selectively discriminate between the explosive molecules for each angle.…”

Section: Electronic Transport Properties Of Tor With Explosive Molecu...mentioning

confidence: 99%