“…From 2002 until 2015, twelve automated segmentation attempts on the MRI thigh muscles have been recorded [12,13,14,15,16,17,18,19,20,21,22,23]), where automation process was done by incorporating either one or combination of these techniques: thresholding (intensity based or histogram modelling); classification (fuzzy c-means (FCM) being the popular approach or k-means); active contour; and/or region growing. These methods focusing on segmenting muscles, marrow, femur, subcutaneous adipose tissue and/or intermuscular adipose tissue as an individual component (or group), whereafter the implementation of suitable pre-processing algorithms (to remove/reduce noise or improve pixel's intensity), this individual component (or group) can be straightforwardly segmented.…”