Automatic segmentation and reconstruction of the cortex from neonatal MRI

Hui-feng, Xue; Srinivasan, Latha; Jiang, Shuo; Rutherford, Mary A.; Edwards, A. David; Rueckert, Daniel; Hajnal, Joseph V.

doi:10.1016/j.neuroimage.2007.07.030

Cited by 192 publications

(240 citation statements)

References 46 publications

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“…Recently there has been an increasing use of T 1 -W and T 2 -W images for brain segmentation in preterm and term neonates [30][31][32][33][34][35][36][37]. Moreover, acquiring volumetric sequences allows for retrospective analyses on the neonates scanned, by having a standardized data set for comparison with future MR studies on the same child.…”

Section: Discussionmentioning

confidence: 99%

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Optimized T1- and T2-weighted volumetric brain imaging as a diagnostic tool in very preterm neonates

et al. 2010

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Background T1-and T 2 -W MR sequences used for obtaining diagnostic information and morphometric measurements in the neonatal brain are frequently acquired using different imaging protocols. Optimizing one protocol for obtaining both kinds of information is valuable. Objective To determine whether high-resolution T1-and T 2 -W volumetric sequences optimized for preterm brain imaging could provide both diagnostic and morphometric value. Materials and methods Thirty preterm neonates born between 24 and 32 weeks' gestational age were scanned during the first 2 weeks after birth. T1-and T 2 -W highresolution sequences were optimized in terms of signal-tonoise ratio, contrast-to-noise ratio and scan time and compared to conventional spin-echo-based sequences. Results No differences were found between conventional and high-resolution T 1 -W sequences for diagnostic confidence, image quality and motion artifacts. A preference for conventional over high-resolution T 2 -W sequences for image quality was observed. High-resolution T1 images provided better delineation of thalamic myelination and the superior temporal sulcus. No differences were found for detection of myelination and sulcation using conventional and high-resolution T 2 -W images. Conclusion High-resolution T1-and T 2 -W volumetric sequences can be used in clinical MRI in the very preterm brain to provide both diagnostic and morphometric information.R. Nossin-Manor (*)

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Section: Discussionmentioning

confidence: 99%

“…These images are also used for segmentation and quantitative morphometric measurements in the developing brain [14,17,[30][31][32][33][34][35][36][37]. Frequently, however, sequences used for clinical diagnosis and morphometric measurements are acquired using different imaging protocols and experimental settings.…”

Section: Introductionmentioning

confidence: 99%

Optimized T1- and T2-weighted volumetric brain imaging as a diagnostic tool in very preterm neonates

et al. 2010

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“…All masks were checked and manually corrected to exclude any nonbrain tissue that can generate mislabeled voxels (Xue et al. 2007) in the subsequent segmentation using ITK‐SNAP (Yushkevich et al. 2006, RRID:SCR_002010).…”

Section: Methodsmentioning

confidence: 99%

Cortical folding of the preterm brain: a longitudinal analysis of extremely preterm born neonates using spectral matching

et al. 2016

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IntroductionInfants born extremely preterm (<28 weeks of gestation) are at risk of significant neurodevelopmental sequelae. In these infants birth coincides with a period of rapid brain growth and development, when the brain is also vulnerable to a range of insults. Mapping these changes is crucial for identifying potential biomarkers to predict early impairment.MethodsIn this study we use surface‐based spectral matching techniques to find an intrasubject longitudinal surface correspondence between the white–grey matter boundary at 30 and 40 weeks equivalent gestational age in nine extremely preterm born infants.ResultsUsing the resulting surface correspondence, we identified regions that undergo more cortical folding of the white–grey matter boundary during the preterm period by looking at changes in well‐known curvature measures. We performed Hotelling T2 statistics to evaluate the significance of our findings.DiscussionThe prefrontal and temporal lobes exhibit most development during the preterm period, especially in the left hemisphere. Such correspondences are a promising result as longitudinal measurements of change in cortical folding could provide insightful information about the mechanical properties of the underlying tissue and may be useful in inferring changes during growth and development in this vulnerable period.

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“…The values of DSC above 70% show clinically acceptable agreement between the 2 segmented regions (20)(21)(22). The DSC index is the most popular criterion used in the literature for ROI validation studies (23)(24)(25), as it is considered the special case of k-statistics (21).…”

Section: Percentage Overlap ðRmentioning

confidence: 99%

Semiautomatic Region-of-Interest Validation at the Femur in 18F-Fluoride PET/CT

Puri

Blake

Curran

et al. 2012

Journal of Nuclear Medicine Technology

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The assessment of regional skeletal metabolism using 18 F-fluoride PET ( 18 F-PET) requires segmentation of the tissue region of interest (ROI). The aim of this study was to validate a novel approach to define multiple ROIs at the proximal femur similar to those used in dual x-ray absorptiometry. Regions were first drawn on low-dose CT images acquired as a routine part of the PET/CT study and transferred to the 18 F-PET images for the quantitative analysis of bone turnover. Methods: Four healthy postmenopausal women with a mean age of 65.1 y (range, 61.8-70.0 y), and with no history of metabolic bone disorder and not currently being administered treatment affecting skeletal metabolism, underwent dynamic 18 F-PET/CT at the hip with an injected activity of 180 MBq. The ROIs at the proximal femur included femoral shaft, femoral neck, and total hip and were segmented using both a semiautomatic method and manually by 8 experts at manual ROI delineation. The mean of the 8 manually drawn ROIs was considered the gold standard against which the performances of the semiautomatic and manual methods were compared in terms of percentage overlap and percentage difference. The time to draw the ROIs was also compared. Results: The percentage overlaps between the gold standard and the semiautomatic ROIs for total hip, femoral neck, and femoral shaft were 86.1%, 37.8%, and 96.1%, respectively, and the percentage differences were 14.5%, 89.7%, and 4.7%, respectively. In the same order, the percentage overlap between the gold standard and the manual ROIs were 85.2%, 39.1%, and 95.2%, respectively, and the percentage differences were 19.9%, 91.6%, and 12.2%, respectively. The semiautomatic method was approximately 9.5, 2.5, and 67 times faster than the manual method for segmenting total-hip, femoral-neck, and femoral-shaft ROIs, respectively. Conclusion: We have developed and validated a semiautomatic procedure whereby ROIs at the hip are defined using the CT component of an 18 F-PET/CT scan. The percentage overlap and percentage difference results between the semiautomatic method and the manual method for ROI delineation were similar. Two advantages of the semiautomatic method are that it is significantly quicker and eliminates some of the variability associated with operator or reader input. The tube current used for the CT scan was associated with an effective dose 8 times lower than that associated with a typical diagnostic CT scan. These results suggest that it is possible to segment bone ROIs from low-dose CT for later transfer to PET in a single PET/CT procedure without the need for an additional high-resolution CT scan. The assessment of regional bone turnover is important in the understanding of the pathophysiology of metabolic bone diseases such as osteoporosis. Studies of the differential response between cortical and trabecular bone to aging, disease, and treatment may provide a better understanding of mechanisms of action of novel treatments currently being developed for osteoporosis (1,2) and allow insight into the rol...

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Automatic segmentation and reconstruction of the cortex from neonatal MRI

Cited by 192 publications

References 46 publications

Optimized T1- and T2-weighted volumetric brain imaging as a diagnostic tool in very preterm neonates

Optimized T1- and T2-weighted volumetric brain imaging as a diagnostic tool in very preterm neonates

Cortical folding of the preterm brain: a longitudinal analysis of extremely preterm born neonates using spectral matching

Semiautomatic Region-of-Interest Validation at the Femur in 18F-Fluoride PET/CT

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