Automatic recognition of explorative strategies in the Morris water maze

Graziano, Alessandro Di; Petrosini, Laura; Bartoletti, Alessandro

doi:10.1016/s0165-0270(03)00187-0

Cited by 88 publications

(82 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The pro-aggregant Tau RD ON mice (at 10 months expression) showed longer escape latency (Fig. 6 A), a measure of cognitive performance (Graziano et al, 2003). Analogous effects of tauopathy on spatial learning were observed for other AD mouse models (Arendash et al, 2004;Ramsden et al, 2005;Denk and Wade-Martins, 2009).…”

Section: Discussionsupporting

confidence: 52%

Tau-Induced Defects in Synaptic Plasticity, Learning, and Memory Are Reversible in Transgenic Mice after Switching Off the Toxic Tau Mutant

et al. 2011

View full text Add to dashboard Cite

This report describes the behavioral and electrophysiological analysis of regulatable transgenic mice expressing mutant repeat domains of human Tau (Tau RD ). Mice were generated to express Tau RD in two forms, differing in their propensity for ␤-structure and thus in their tendency for aggregation ("pro-aggregant" or "anti-aggregant") (Mocanu et al., 2008). Only pro-aggregant mice show pronounced changes typical for Tau pathology in Alzheimer's disease (aggregation, missorting, hyperphosphorylation, synaptic and neuronal loss), indicating that the ␤-propensity and hence the ability to aggregate is a key factor in the disease. We now tested the mice with regard to neuromotor parameters, behavior, learning and memory, and synaptic plasticity and correlated this with histological and biochemical parameters in different stages of switching Tau RD on or off. The mice are normal in neuromotor tests. However, pro-aggregant Tau RD mice are strongly impaired in memory and show pronounced loss of long-term potentiation (LTP), suggesting that Tau aggregation specificallyperturbsthesebrainfunctions.Remarkably,whentheexpressionofhumanpro-aggregantTau RD isswitchedonforϳ10monthsand off for ϳ4 months, memory and LTP recover, whereas aggregates decrease moderately and change their composition from mixed human plus mouse Tau to mouse Tau only. Neuronal loss persists, but synapses are partially rescued. This argues that continuous presence of amyloidogenic pro-aggregant Tau RD constitutes the main toxic insult for memory and LTP, rather than the aggregates as such.

show abstract

Section: Discussionsupporting

confidence: 52%

Tau-Induced Defects in Synaptic Plasticity, Learning, and Memory Are Reversible in Transgenic Mice after Switching Off the Toxic Tau Mutant

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Therefore, swim speed did not account for poor performance in the aged rats. Additionally, poor performance by cognitively impaired aged rats was not attributable to thigmotaxis, which is a tendency of the animal to swim in contact with the pool wall (Graziano et al, 2003). All rats (young, aged unimpaired, aged impaired) swam in each zone (Fig.…”

Section: Preselection Of Aged Cognitively Impaired Ratsmentioning

confidence: 90%

“…The swim speeds and distances were recorded using a video tracking system (HVS Image, Buckingham, UK) to exclude motor deficits as the cause of poor performance, as described (Rowe et al, 2003). For excluding thigmotaxis and amotivational status as the cause of poor performance (Graziano et al, 2003;Rowe et al, 2003), concentric zones of the pool defined by the software program (HVS Image) were used to average swim patterns during days 2-5 of the acquisition phase.…”

Section: Behavioral Taskmentioning

confidence: 99%

Long-Lasting Rescue of Age-Associated Deficits in Cognition and the CNS Cholinergic Phenotype by a Partial Agonist Peptidomimetic Ligand of TrkA

Bruno¹,

Clarke²,

Seltzer³

et al. 2004

J. Neurosci.

View full text Add to dashboard Cite

Previously, we developed a proteolytically stable small molecule peptidomimetic termed D3 as a selective ligand of the extracellular domain of the TrkA receptor for the NGF. Ex vivo D3 was defined as a selective, partial TrkA agonist. Here, the in vivo efficacy of D3 as a potential therapeutic for cholinergic neurons was tested in cognitively impaired aged rats, and we compared the consequence of partial TrkA activation (D3) versus full TrkA/p75 activation (NGF). We show that in vivo D3 binds to TrkA receptors and affords a significant and long-lived phenotypic rescue of the cholinergic phenotype both in the cortex and in the nucleus basalis. The cholinergic rescue was selective and correlates with a significant improvement of memory/learning in cognitively impaired aged rats. The effects of the synthetic ligand D3 and the natural ligand NGF were comparable. Small, proteolytically stable ligands with selective agonistic activity at a growth factor receptor may have therapeutic potential for neurodegenerative disorders.

show abstract

“…The variance of around 30% covered by the first components does not reach that in studies with a lower number of behavioral categories of about 80% Graziano et al, 2003). But in view of the underlying complexity of the swim paths, with 100 possible factors to be extracted, the accumulation of 30% of the total variance is a sufficient result.…”

Section: Discussionmentioning

confidence: 85%

“…A multivariate approach, which reduces the dimensionality of all variables to a few extracted factors on which the original variables can be projected by means of correlations, has been suggested by Wolfer, Stagljar-Bozicevic, Errington, and Lipp (1998). A second approach has been recently made by Graziano, Petrosini, and Bartoletti (2003), using discriminant analysis for swimpattern recognition. These more sophisticated analyses reveal subtle but significant differences between spatial and nonspatial cognitive strategies in water maze performance.…”

mentioning

confidence: 99%

Water maze swim path analysis based on tracking coordinates

Korz

2006

Behavior Research Methods

View full text Add to dashboard Cite

Automatic recognition of explorative strategies in the Morris water maze

Cited by 88 publications

References 18 publications

Tau-Induced Defects in Synaptic Plasticity, Learning, and Memory Are Reversible in Transgenic Mice after Switching Off the Toxic Tau Mutant

Tau-Induced Defects in Synaptic Plasticity, Learning, and Memory Are Reversible in Transgenic Mice after Switching Off the Toxic Tau Mutant

Long-Lasting Rescue of Age-Associated Deficits in Cognition and the CNS Cholinergic Phenotype by a Partial Agonist Peptidomimetic Ligand of TrkA

Water maze swim path analysis based on tracking coordinates

Contact Info

Product

Resources

About