Automatic Radiobiological Comparison of Radiation Therapy Plans: An Application to Gastric Cancer

Mazonakis, Michalis; Tzanis, Eleftherios; Lyraraki, Efrossyni; Damilakis, John

doi:10.3390/cancers14246098

Cited by 3 publications

(2 citation statements)

References 29 publications

(33 reference statements)

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“…The equivalent uniform dose (EUD)-based model was employed to determine the NTCP for the heavily irradiated OARs [ 20 , 21 ]. An in-house software tool developed using Python 3.8 was employed for these calculations [ 22 ]. Data from differential DVHs directly exported by the treatment planning system could be easily retrieved by the software.…”

Section: Methodsmentioning

confidence: 99%

“…The NTCP calculations were carried out using the following equation:

where TD 50 is the tolerance radiation dose associated with a complication probability of 50% and γ 50 is a unitless organ-specific model parameter related to the slope of the dose–response curve. The parameters employed for calculating the NTCP of the lungs, heart and esophagus are shown in Table 2 [ 22 ].…”

Section: Methodsmentioning

confidence: 99%

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NTCP Calculations of Five Different Irradiation Techniques for the Treatment of Thymoma

Mazonakis,

Kachris,

Tolia

et al. 2023

Current Oncology

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This study provided normal tissue complication probability (NTCP) calculations from photon radiotherapy techniques in eleven patients with thymoma. Five plans were created for each participant using three-dimensional conformal radiotherapy (3D-CRT), five-field intensity modulated radiotherapy (5F-IMRT), seven-field IMRT (7F-IMRT), and volumetric modulated arc therapy with full arcs (FA-VMAT) and partial arcs (PA-VMAT). The target coverage, homogeneity index and conformation number for the planning target volume (PTV) and dosimetric parameters for the organs-at-risk (OARs) were taken from the fifty-five generated plans. The patient-specific NTCP of the lungs, heart and esophagus was calculated with an in-house software tool using differential dose-volume histograms and the equivalent uniform dose model. The PTV dose metrics from 3D-CRT were inferior to those from IMRT and VMAT plans. The dose constraints for the OARs were met in all treatment plans. The NTCP range of the lungs, heart and esophagus was 0.34–0.49%, 0.03–0.06% and 0.08–0.10%, respectively. The NTCPs of the heart for the incidence of peridarditis from IMRT and VMAT were significantly smaller than those from conformal treatment (p < 0.05). The 7F-IMRT was significantly superior to FA-VMAT in reducing the NTCP of the lungs and the risk of pneumonitis (p = 0.001). Similar superiority of 5F-IMRT over PA-VMAT for lung protection was found (p = 0.009). The presented results may be employed in the selection of the appropriate irradiation technique for restricting the complications in the adjacent OARs.

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Section: Methodsmentioning

confidence: 99%

“…The NTCP calculations were carried out using the following equation:

Section: Methodsmentioning

confidence: 99%

NTCP Calculations of Five Different Irradiation Techniques for the Treatment of Thymoma

Mazonakis,

Kachris,

Tolia

et al. 2023

Current Oncology

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Integral dose comparison of VMAT and IMRT for rectal cancer treatment: A dosimetric analysis

Yeh

2024

Radiation Physics and Chemistry

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Risk of Radiation-Induced Second Primary Cancers and Cardiotoxicity following Therapeutic Irradiation for Thymoma with Photon Beams: A Treatment Planning Study

Mazonakis,

Kachris,

Tolia

et al. 2024

Applied Sciences

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This study compared the risks for developing second primary cancers and cardiotoxicity following radiotherapy for thymoma. Three different 3D-CRT, IMRT, and VMAT plans were generated with 6 MV photons for 12 females with thymoma. Dose-volume histogram data were employed to estimate the second cancer risks using a mechanistic non-linear model. The radiation doses to the heart and cardiac substructures were combined with linear models to assess the probability of cardiotoxicity. The mean lifetime risk for lung, esophageal, thyroid, left breast, and right breast cancer induction was 4.34–4.49%, 0.30–0.31%, 0.05–0.07%, 2.06–2.30%, and 2.04–2.34%, respectively, depending upon the radiotherapy technique. The relative risk for major cardiac events, including myocardial infarction, coronary revascularization, and death, was 1.43–1.55, whereas that for chronic heart failure was 1.20–1.29. The IMRT and VMAT significantly reduced the risk for cardiotoxicity with respect to 3D-CRT (p ≤ 0.023). Small but significant reductions were observed for most organ-specific cancer risks with IMRT compared to conformal treatment (p ≤ 0.008). Similar decreases were detected only for esophageal and thyroid cancer with VMAT (p ≤ 0.033). No difference was found in the probability for radiation-induced lung cancer with the three techniques (p ≥ 0.06). Healthcare professionals may use these data to select the appropriate radiotherapy technique and restrict the risk of late effects.

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Automatic Radiobiological Comparison of Radiation Therapy Plans: An Application to Gastric Cancer

Cited by 3 publications

References 29 publications

NTCP Calculations of Five Different Irradiation Techniques for the Treatment of Thymoma

NTCP Calculations of Five Different Irradiation Techniques for the Treatment of Thymoma

Integral dose comparison of VMAT and IMRT for rectal cancer treatment: A dosimetric analysis

Risk of Radiation-Induced Second Primary Cancers and Cardiotoxicity following Therapeutic Irradiation for Thymoma with Photon Beams: A Treatment Planning Study

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