Automatic quantification of white matter hyperintensities on T2-weighted fluid attenuated inversion recovery magnetic resonance imaging

Igwe, Kay C.; Lao, Patrick J.; Vorburger, Robert S.; Banerjee, Arit; Rivera, Andrés; Chesebro, Anthony G.; Laing, Krystal K; Manly, Jennifer J.; Brickman, Adam M.

doi:10.1016/j.mri.2021.10.007

Cited by 8 publications

(3 citation statements)

References 40 publications

(51 reference statements)

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“…In the Offspring study, FLAIR images were brain extracted, then corrected for intensity inhomogeneities . The intensity histogram was high pass filtered at the mode, log-transformed, and fit with a half Gaussian mixture model where the upper full Gaussian represented WMH . WMH were visually inspected and manually corrected if needed (Figure 1B and C); labeled voxels were summed and multiplied by voxel dimensions to yield volumes in cm 3 .…”

Section: Methodsmentioning

confidence: 99%

Brain Aging Among Racially and Ethnically Diverse Middle-Aged and Older Adults

et al. 2023

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ImportanceNeuroimaging studies have documented racial and ethnic disparities in brain health in old age. It remains unclear whether these disparities are apparent in midlife.ObjectiveTo assess racial and ethnic disparities in magnetic resonance imaging (MRI) markers of cerebrovascular disease and neurodegeneration in midlife and late life.Design, Setting, and ParticipantsData from 2 community-based cohort studies, Washington Heights–Inwood Columbia Aging Project (WHICAP) and the Offspring Study of Racial and Ethnic Disparities in Alzheimer Disease (Offspring), were used. Enrollment took place from March 2011 and June 2017, in WHICAP and Offspring, respectively, to January 2021. Of the 822 Offspring and 1254 WHICAP participants approached for MRI scanning, 285 and 176 refused participation in MRI scanning, 36 and 76 were excluded for contraindications/ineligibility, and 4 and 32 were excluded for missing key variables, respectively.Main Outcomes and MeasuresCortical thickness in Alzheimer disease–related regions, white matter hyperintensity (WMH) volume.ResultsThe final sample included 1467 participants. Offspring participants (497 [33.9%]) had a mean (SD) age of 55 (10.7) years, had a mean (SD) of 13 (3.5) years of education, and included 117 Black individuals (23.5%), 348 Latinx individuals (70%), 32 White individuals (6.4%), and 324 women (65.2%). WHICAP participants (970 [66.1%]) had a mean (SD) age of 75 (6.5) years, had a mean (SD) of 12 (4.7) years of education, and included 338 Black individuals (34.8%), 389 Latinx individuals (40.1%), 243 White individuals (25.1%), and 589 women (65.2%). Racial and ethnic disparities in cerebrovascular disease were observed in both midlife (Black-White: B = 0.357; 95% CI, 0.708-0.007; P = .046) and late life (Black-Latinx: B = 0.149, 95% CI, 0.068-0.231; P &lt; .001; Black-White: B = 0.166; 95% CI, 0.254-0.077; P &lt; .001), while disparities in cortical thickness were evident in late life only (Black-Latinx: B = −0.037; 95% CI, −0.055 to −0.019; P &lt; .001; Black-White: B = −0.064; 95% CI −0.044 to −0.084; P &lt; .001). Overall, Black-White disparities were larger than Latinx-White disparities for cortical thickness and WMH volume. Brain aging, or the association of age with MRI measures, was greater in late life compared with midlife for Latinx (cortical thickness: B = 0.006; 95% CI, 0.004-0.008; P &lt; .001; WMH volume: B = −0.010; 95% CI, −0.018 to −0.001; P = .03) and White (cortical thickness: B = 0.005; 95% CI, 0.002-0.008; P = .001; WMH volume: B = −0.021; 95% CI −0.043 to 0.002; P = .07) participants but not Black participants (cortical thickness: B = 0.001; 95% CI, −0.002 to 0.004; P =.64; WMH volume: B = 0.003; 95% CI, −0.010 to 0.017; P = .61), who evidenced a similarly strong association between age and MRI measures in midlife and late life.Conclusions and RelevanceIn this study, racial and ethnic disparities in small vessel cerebrovascular disease were apparent in midlife. In Latinx and White adults, brain aging was more pronounced in late life than midlife, whereas Black adults showed accelerated pattern of brain aging beginning in midlife.

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Section: Methodsmentioning

confidence: 99%

Brain Aging Among Racially and Ethnically Diverse Middle-Aged and Older Adults

et al. 2023

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“…The Alzheimer’s Disease Neuroimaging Initiative MRI protocol was used at all sites (T1-weighted scan: repetition time (TR)/echo time (TE)/inversion time (TI): 2300/2.96/900ms; voxel size: 1x1x1mm 3 ; T2-weighted fluid attenuated inversion recovery (FLAIR) scan (TR/TE/TI: 5000/386/1800ms; voxel size: 0.4x0.4x0.9mm 3 ); and a T2-*-weighted gradient echo (GRE) scan (TR/TE: 650/20ms; voxel size: 0.8x0.8x4mm 3 ) or susceptibility weighted image (SWI: TRE/TE: 27/30ms; voxel size: 0.9x0.9x1.5 mm 3 )). Total and regional (by cerebral lobe) WMH volumes were quantified from T2-weighted FLAIR scans, using a previously described method 19,45 . Parietal and occipital WMH were summed to derive parieto-occipital WMH volume.…”

Section: Methodsmentioning

confidence: 99%

Pathways linking pulse pressure to dementia in adults with Down syndrome

Rizvi,

Lao,

Sathishkumar

et al. 2023

Preprint

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Individuals with Down syndrome (DS) are less likely to have hypertension than neurotypical adults. However, whether blood pressure measures are associated with brain health and clinical outcomes in this population has not been studied in detail. Here, we assessed whether pulse pressure is associated with markers of cerebrovascular disease, entorhinal cortical atrophy, and diagnosis of dementia in adults with DS. Participants with DS from the Biomarkers of Alzheimer's Disease in Adults with Down Syndrome study (ADDS; n = 195, mean age (SD) = 50.6 (7.2), 44% women, 18% diagnosed with dementia) were included. Higher pulse pressure was associated with greater global, parietal, and occipital WMH volume. Pulse pressure was not related to enlarged PVS, microbleeds, infarcts, entorhinal cortical thickness, or dementia diagnosis. However, in a serial mediation model, we found that pulse pressure was indirectly related to dementia diagnosis through parieto-occipital WMH and, subsequently through entorhinal cortical thickness. Higher pulse pressure may be a risk factor for dementia in people with DS by promoting cerebrovascular disease, which in turn affects neurodegeneration. Pulse pressure is an important determinant of brain health and clinical outcomes in individuals with Down syndrome despite the low likelihood of frank hypertension.

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“…Total and regional WMHs were derived by applying a half Gaussian mixture model to intensity‐normalized FLAIR images, summing the number of labeled voxels, and multiplying the sum by the voxel dimensions to yield volumes in cm 3 37 . Outcome measures included total volume and volumes in frontal, temporal, parietal, and occipital lobes.…”

Section: Methodsmentioning

confidence: 99%

Probing the proteome to explore potential correlates of increased Alzheimer's‐related cerebrovascular disease in adults with Down syndrome

Moni

Petersen

Zhang

et al. 2022

Alzheimer's & Dementia

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Cerebrovascular disease is associated with symptoms and pathogenesis of Alzheimer's disease (AD) among adults with Down syndrome (DS). The cause of increased dementia-related cerebrovascular disease in DS is unknown. We explored whether protein markers of neuroinflammation are associated with markers of cerebrovascular disease among adults with DS. Participants from the Alzheimer's disease in Down syndrome (ADDS) study with magnetic resonance imaging (MRI) scans and blood biomarker data were included. Support vector machine (SVM) analyses examined the relationship of blood-based proteomic biomarkers with MRI-defined cerebrovascular disease among participants characterized as having cognitive decline (n = 36, mean age ± SD = 53 ± 6.2) and as being cognitively stable (n = 78, mean age = 49 ± 6.4).Inflammatory and AD markers were associated with cerebrovascular disease, particularly among symptomatic individuals. The pattern suggested relatively greater 1744

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Automatic quantification of white matter hyperintensities on T2-weighted fluid attenuated inversion recovery magnetic resonance imaging

Cited by 8 publications

References 40 publications

Brain Aging Among Racially and Ethnically Diverse Middle-Aged and Older Adults

Brain Aging Among Racially and Ethnically Diverse Middle-Aged and Older Adults

Pathways linking pulse pressure to dementia in adults with Down syndrome

Probing the proteome to explore potential correlates of increased Alzheimer's‐related cerebrovascular disease in adults with Down syndrome

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