Automatic Planning for Nasopharyngeal Carcinoma Based on Progressive Optimization in RayStation Treatment Planning System

Yang, Yiwei; Shao, Kwang‐Tsao; Zhang, Jie; Chen, Ming; Chen, Yuanyuan; Shan, Guihua

doi:10.1177/1533033820915710

Cited by 21 publications

(16 citation statements)

References 31 publications

(37 reference statements)

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“…For most of the OARs, the dosimetric parameters of APs were superior to that of MPs, while the pass rates were usually higher than or equal to MPs, as also concluded by Yang et al 25 and Wang et al 26 . APs could automatically generate a number of auxiliary structures for the dose limiting, which was di cult to accomplish manually.…”

Section: Discussionsupporting

confidence: 65%

Evaluation of Auto-Planning in VMAT for Locally Advaced Nasopharyngeal Carcinoma

Chen

Dai

et al. 2021

Preprint

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The aim of this study is to demonstrate the feasibility of Auto-Planning module for locally advanced nasopharyngeal carcinoma (NPC). A total of 22 patients with locally advanced NPC were enrolled in this study. For each patient, volumetric modulated arc therapy (VMAT) plans were generated manually by an experienced physicist and automatically by the Auto-Planning module. The dose distribution, dosimetric parameters, monitor units and planning time were compared between automatic plans (APs) and manual plans (MPs). Meanwhile, the overall stage of disease was factored into the evaluation. The targets dose coverage of APs was similar to that of MPs. For most of the organs at risk (OARs) except spial cord, the dose parameters of APs were superior to that of MPs. The Dmax and V50 of brain-stem were statistically decreased by 1.0 Gy and 1.32% respectively, while the Dmax of optic nerves and optic chiasm were also lower in the APs (both P < 0.05). APs provide a similar or superior plan quality to MPs in most cases, except for several patients with stage IV. The dose differences for most OARs were similar between the two types of plans and independent of the overall stage. Nevertheless, the APs provided better brain-stem sparing in patients with stage III, while better the parotid glands sparing in patients with stage IV. Moreover, the monitor units and planning time were significantly decreased in the APs. In general, Auto-Planning was a potential technology on the implementation of VMAT treatment planning for locally advanced NPC.

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Section: Discussionsupporting

confidence: 65%

Evaluation of Auto-Planning in VMAT for Locally Advaced Nasopharyngeal Carcinoma

Chen

Dai

et al. 2021

Preprint

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“…Treatment plans were evaluated based on dose conformity, dose homogeneity, and OAR sparing 48–55 . We adopt the following definitions (Equations and ) of the conformity index (CI) 55 and homogeneity index (HI) 54 :

CI = \frac{{(T V_{95 D_{p}})}^{2}}{T V \times V_{95 D_{p}}}

HI = \frac{D_{5} - D_{95}}{D_{p}} .

…”

Section: Resultsmentioning

confidence: 99%

“…Though our proposed method can be applied to both IMRT and VMAT, we mainly apply NC-POPS to IMRT planning Treatment plans were evaluated based on dose conformity, dose homogeneity, and OAR sparing. [48][49][50][51][52][53][54][55] We adopt the following definitions (Equations 7 and 8) of the conformity index (CI) 55 and homogeneity index (HI) 54 :…”

Section: Experimental Setup and Evaluationmentioning

confidence: 99%

Fully automated noncoplanar radiation therapy treatment planning

Huang

Yang

2021

Medical Physics

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To perform fully automated noncoplanar (NC) treatment planning, we propose a method called NC-POPS to produce NC plans using the Pareto optimal projection search (POPS) algorithm. Methods: NC radiation therapy treatment planning has the potential to improve dosimetric quality as compared to traditional coplanar techniques. Likewise, automated treatment planning algorithms can reduce a planner's active treatment planning time and remove inter-planner variability. Our NC-POPS algorithm extends the original POPS algorithm to the NC setting with potential applications to both intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT). The proposed algorithm consists of two main parts: (1) NC beam angle optimization (BAO) and (2) fully automated inverse planning using the POPS algorithm. Results: We evaluate the performance of NC-POPS by comparing between various NC and coplanar configurations. To evaluate plan quality, we compute the homogeneity index (HI), conformity index (CI), and dose-volume histogram statistics for various organs-at-risk (OARs).As compared to the evaluated coplanar baseline methods, the proposed NC-POPS method achieves significantly better OAR sparing, comparable or better dose conformity, and similar dose homogeneity. Conclusions: Our proposed NC-POPS algorithm provides a modular approach for fully automated treatment planning of NC IMRT cases with the potential to substantially improve treatment planning workflow and plan quality.

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“…To achieve an accurate and dosimetric distribution of 125 I-seed implantation, treatment-planning system was applied for the 125 I treatment (TPS; standard version; Beijing ASTRO Technology Development Co., Ltd.) based on the American Association of Physicists in Medicine TG43 brachytherapy formalism (21)(22)(23)(24)(25). Dose, seed distribution, and depth of needles of each patient were determined preoperatively via TPS (Table 2 and Supplemental Figure 2).…”

Section: Local Single Needle Cone Puncture-125 I Seed (Sncp-125 I) Brachytherapy Proceduresmentioning

confidence: 99%

A Retrospective Study on Using a Novel Single Needle Cone Puncture Approach for the Iodine-125 Seed Brachytherapy in Treating Patients With Thoracic Malignancy

Wang

Zhang

et al. 2021

Front. Oncol.

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BackgroundPatients with progressive thoracic malignancy characterized by large irregular tumors with necrosis and life-threatening symptoms lack effective treatments. We set out to develop a single needle cone puncture method for the Iodine-125 seed (SNCP-125I) brachytherapy, and aim to report the initial results.Methods294 patients with advanced thoracic malignancy were treated with local SNCP-125I brachytherapy between March 2009 and July 2020, followed by thorough evaluation of clinical outcome, overall survival (OS), progression-free survival (PFS) and procedure-related complications after treatment.ResultsThe overall response rate (ORR) among the treated patients was 81.0% (238/294). Life-threatening symptoms due to tumor oppression, hemoptysis and large irregular tumor with necrosis were successfully alleviated after the SNCP-125I treatment with a remission rate at 91% to 94%. The median OS and PFS were 13.6 months and 5.8 months, respectively. Procedure-related side effects including pneumothorax (32/294), blood-stained sputum (8/294), subcutaneous emphysema (10/294), puncture site bleeding (16/294) and chest pain (6/294) were observed. Patients who were able to follow with chemotherapy or immunotherapy experienced extended OS and PFS, as compared with patients who opted to receive hospice care (16.5 months Vs. 11.2 months). Further pathological and immunological analysis showed that SNCP-125I induced tumor lymphocytes infiltration and long-term tumor necrosis.ConclusionSNCP-125I brachytherapy effectively eliminates life-threatening symptoms due to local tumor oppression, hemoptysis and large irregular and necrotic tumors in patients with unresectable chest malignancy and significantly induces local tumor regression. SNCP-125I brachytherapy combines with chemotherapy significantly prolong OS and PFS compare with SNCP-125I brachytherapy alone.

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Automatic Planning for Nasopharyngeal Carcinoma Based on Progressive Optimization in RayStation Treatment Planning System

Cited by 21 publications

References 31 publications

Evaluation of Auto-Planning in VMAT for Locally Advaced Nasopharyngeal Carcinoma

Evaluation of Auto-Planning in VMAT for Locally Advaced Nasopharyngeal Carcinoma

Fully automated noncoplanar radiation therapy treatment planning

A Retrospective Study on Using a Novel Single Needle Cone Puncture Approach for the Iodine-125 Seed Brachytherapy in Treating Patients With Thoracic Malignancy

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