Automatic Parametrization of Somatosensory Evoked Potentials With Chirp Modeling

Väyrynen, Eero; Noponen, Kai; Vipin, Ashwati; Thow, Xin Yuan; Al‐Nashash, Hasan; Kortelainen, Jukka; All, Angelo H.

doi:10.1109/tnsre.2016.2525829

Cited by 10 publications

(3 citation statements)

References 21 publications

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“…Typically, recordings are followed by real-time and or offline signal processing, which enables scientists to (i) detect the onset and progress of trauma, (ii) qualify and quantify the severity of SCI, and (iii) identify and distinguish even minuscule changes that could be due to the endogenous repair or exogenous therapeutic recovery. A few main methods of SSEP signal processing techniques are shape analysis [42,43], spectral coherence [44], slope analysis [45], adaptive coherence [46], chirp modeling [47], sparse modeling [48], as well as several other methods [49][50][51][52][53].…”

Section: Signal Analysismentioning

confidence: 99%

Hypothermia effects on neuronal plasticity post spinal cord injury

Al-Nashash,

Wong,

ALL

2024

PLoS ONE

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Background SCI is a time-sensitive debilitating neurological condition without treatment options. Although the central nervous system is not programmed for effective endogenous repairs or regeneration, neuroplasticity partially compensates for the dysfunction consequences of SCI. Objective and hypothesis The purpose of our study is to investigate whether early induction of hypothermia impacts neuronal tissue compensatory mechanisms. Our hypothesis is that although neuroplasticity happens within the neuropathways, both above (forelimbs) and below (hindlimbs) the site of spinal cord injury (SCI), hypothermia further influences the upper limbs’ SSEP signals, even when the SCI is mid-thoracic. Study design A total of 30 male and female adult rats are randomly assigned to four groups (n = 7): sham group, control group undergoing only laminectomy, injury group with normothermia (37°C), and injury group with hypothermia (32°C +/-0.5°C). Methods The NYU-Impactor is used to induce mid-thoracic (T8) moderate (12.5 mm) midline contusive injury in rats. Somatosensory evoked potential (SSEP) is an objective and non-invasive procedure to assess the functionality of selective neuropathways. SSEP monitoring of baseline, and on days 4 and 7 post-SCI are performed. Results Statistical analysis shows that there are significant differences between the SSEP signal amplitudes recorded when stimulating either forelimb in the group of rats with normothermia compared to the rats treated with 2h of hypothermia on day 4 (left forelimb, p = 0.0417 and right forelimb, p = 0.0012) and on day 7 (left forelimb, p = 0.0332 and right forelimb, p = 0.0133) post-SCI. Conclusion Our results show that the forelimbs SSEP signals from the two groups of injuries with and without hypothermia have statistically significant differences on days 4 and 7. This indicates the neuroprotective effect of early hypothermia and its influences on stimulating further the neuroplasticity within the upper limbs neural network post-SCI. Timely detection of neuroplasticity and identifying the endogenous and exogenous factors have clinical applications in planning a more effective rehabilitation and functional electrical stimulation (FES) interventions in SCI patients.

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Section: Signal Analysismentioning

confidence: 99%

Hypothermia effects on neuronal plasticity post spinal cord injury

Al-Nashash,

Wong,

ALL

2024

PLoS ONE

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“…The SSEP measurement is a non-invasive procedure and is performed routinely in clinical settings and in the research models of SCI. It provides objective assessments of the onset, severity, and progress of the injury, as well as the endogenous and therapeutic recovery post-SCI [ 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ]. The SSEP has extensively been used to assess stem cell replacement therapy [ 52 , 53 , 54 , 55 ] as well as plasticity and reorganization of neuropathways [ 31 , 56 ] post-SCI as well.…”

Section: Neuroelectrophysiology Monitoringmentioning

confidence: 99%

Neuroprotective Role of Hypothermia in Acute Spinal Cord Injury

Al‐Nashash

All

2022

Biomedicines

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Even nowadays, the question of whether hypothermia can genuinely be considered therapeutic care for patients with traumatic spinal cord injury (SCI) remains unanswered. Although the mechanisms of hypothermia action are yet to be fully explored, early hypothermia for patients suffering from acute SCI has already been implemented in clinical settings. This article discusses measures for inducing various forms of hypothermia and summarizes several hypotheses describing the likelihood of hypothermia mechanisms of action. We present our objective neuro-electrophysiological results and demonstrate that early hypothermia manifests neuroprotective effects mainly during the first- and second-month post-SCI, depending on the severity of the injury, time of intervening, duration, degree, and modality of inducing hypothermia. Nevertheless, eventually, its beneficial effects gradually but consistently diminish. In addition, we report potential complications and side effects for the administration of general hypothermia with a unique referment to the local hypothermia. We also provide evidence that instead of considering early hypothermia post-SCI a therapeutic approach, it is more a neuroprotective strategy in acute and sub-acute phases of SCI that mostly delay, but not entirely avoid, the natural history of the pathophysiological events. Indeed, the most crucial rationale for inducing early hypothermia is to halt these devastating inflammatory and apoptotic events as early and as much as possible. This, in turn, creates a larger time-window of opportunity for physicians to formulate and administer a well-designed personalized treatment for patients suffering from acute traumatic SCI.

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“…Furthermore, in most models, general classes of response profiles are modeled, rather than being able to model individual response profiles. Particle swarm optimization has been used in many computational biology models, including fitting somatosensory responses to chirp functions 43 and training recurrent neural networks which model gene regulatory networks. 21 Van Geit et al 41 developed an optimization program which allows for the optimization of neuron model parameters to fit time dependent traces.…”

Section: Introductionmentioning

confidence: 99%

Hierarchical winner-take-all particle swarm optimization social network for neural model fitting

et al. 2016

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Particle swarm optimization (PSO) has gained widespread use as a general mathematical programming paradigm and seen use in a wide variety of optimization and machine learning problems. In this work, we introduce a new variant on the PSO social network and apply this method to the inverse problem of input parameter selection from recorded auditory neuron tuning curves. The topology of a PSO social network is a major contributor to optimization success. Here we propose a new social network which draws influence from winner-take-all coding found in visual cortical neurons. We show that the winner-take-all network performs exceptionally well on optimization problems with greater than 5 dimensions and runs at a lower iteration count as compared to other PSO topologies. Finally we show that this variant of PSO is able to recreate auditory frequency tuning curves and modulation transfer functions, making it a potentially useful tool for computational neuroscience models.

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Automatic Parametrization of Somatosensory Evoked Potentials With Chirp Modeling

Cited by 10 publications

References 21 publications

Hypothermia effects on neuronal plasticity post spinal cord injury

Hypothermia effects on neuronal plasticity post spinal cord injury

Neuroprotective Role of Hypothermia in Acute Spinal Cord Injury

Hierarchical winner-take-all particle swarm optimization social network for neural model fitting

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