Automatic microanalysers?V

Organic elemental analysis

“…the nucleic acid is first modified with chloracetaldehyde to give etheno derivatives with adenine and cytosine, then each adenine residue will also bind an Os atom (31). An elegant procedure for producing double stranded DNA with particular nucleotides labeled was introduced by Strothkamp and Lippard (32) who incorporated phosphorothioate groups into DNA in an enzymatic synthesis and showed the sulfur-containing nucleotides specifically bound to platinum atoms. These reactions allow specific labeling protocols for various groups of bases in nucleic acids and promise to be useful in establishing sites of binding of proteins.…”