Automatic estimation of left atrial function from short axis CINE-MRI using machine learning

Abstract

Introduction The importance of atrial mechanical dysfunction in atrial and ventricular pathologies is becoming increasingly recognised. Although machine learning (ML) tools have the ability to automatically estimate atrial function, to date ML techniques have not been used to automatically estimate atrial volumes and functional parameters directly from short axis CINE MRI. Purpose We introduce a convolutional neural network (CNN) to automatically segment the left atria (LA) in CINE-MRI. As a demonstration of the clinical utility of this technique, we calculated LA and left ventricular (LV) ejection fractions automatically from CINE images. Methods Short axis CINE MRI stacks, covering both ventricles and atria, were obtained in a 1.5T Philips Ingenia scanner. A 2D bSSFP ECG-gated protocol was used (FA=60°, TE/TR=1.5/2.9 ms), typical FOV =385 x 310 x 150 mm3, acquisition matrix = 172 x 140, slice thickness = 10 mm, reconstructed with resolution 1.25 x 1.25 x 10 mm3, 30–50 cardiac phases. Images were collected from 37 AF patients in sinus rythm at the time of scan (31–72 years old, 75% male, 18 with paroxysmal AF (PAF), 19 with persistent AF (persAF)). To automatically segment the LA, we used a dedicated CNN that follows a U-Net architecture and was trained in 715 images of the LA, manually segmented by an expert. Data augmentation techniques that included noise addition and linear and non-linear image transforms were also used to increase the training dataset. Ventricular structures, including the LV blood pool, were automatically segmented in these images using a CNN previously trained for this task. Volumetric time plots of LA and LV volume were produced and used to automatically compute maximal and minimal volumes, from which LA and LV ejection fractions (EFs) were assessed. A Bland-Altman analysis compared these automatically computed LA volumes and LA EFs with clinical manual estimates from the same scanning session. Results The CNN achieved very good quality LA segmentations when compared to manual ones (Fig a,b): Dice coefficients (0.90±0.07), median contour distances (0.50±1.12mm) and Hausdorff distances (6.70±6.16mm). Bland-Altman analyses show very good agreement between automatic and manual LA volumes and EFs (Fig e). A moderate linear correlation between LA and LV EFs in AF patients was found (Fig d). The measured LA EF was higher for PAF (29±8%) than PersAF patients (21±11%), although non-significantly (t-test p-value: 0.10). Conclusions We present a reliable automatic method to perform LA segmentations from CINE MRI across the entire cardiac cycle. This approachs opens up the possibility of automatically calculating more sophisticated biomarkers of LA function which take into account information about LA volumes across the entire cardiac cycle, including biomarkers of LA booster pump function. Figure 1 Funding Acknowledgement Type of funding source: Foundation. Main funding source(s): British Heart Foundation; EPSRC/Wellcome Centre for Medical Engineering

Associations between fully-automated, 3D-based functional analysis of the left atrium and classification schemes in atrial fibrillation

“…Longer acquisition times for 3D coverage of the LA and the time-consuming manual LA segmentation might explain the limited number of cMRI studies analyzing LA function based on 3D datasets in the past [29,34,35]. Recently, there were reports of AI tools segmenting the LA on CINE series for biplane or short axis-based assessment but not for oblique-axial orientation [36][37][38].…”