Automatic drug delivery in anesthesia - the design of an anesthesia assistant system

Simanski, Olaf; Kaehler, Ralf; Schubert, A.; Janda, Matthias; Bajorat, J.; Hofmockel, R.; Lampe, Bernhard P.

doi:10.3182/20080706-5-kr-1001.01624

Cited by 3 publications

(2 citation statements)

References 25 publications

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“…The self-calibration procedure assumes that the linear dynamics (4) of the process is accurate, and the error observed in the reference tracking is due to the presence of identification errors in the nonlinear parameters in (6). Consequently, in order to overcome the presence of this type of parameter uncertainties, a calibration procedure is automatically called whenever 1) |y(kh) − y * | > y tr , where y tr is a design parameters (equal to 5% by default); 2) the self-calibration time (t calib =5 min) has elapsed; or 3) it is manually triggered by the anesthesiologist.…”

Section: Self-calibrationmentioning

confidence: 99%

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Self-calibrating total-mass controller for the neuromuscular blockade matching the anesthesiologists' mindset

Paz

Silva

Esteves

et al. 2013

21st Mediterranean Conference on Control and Automation

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A self-calibrating total-mass controller for the neuromuscular blockade (NMB) based on the minimally parameterized parsimonious (MPP) Wiener model is presented. Using input-output data collected from the initial bolus administration until recovery, the parameters of the MPP model that are used for the controller design are chosen from a set of fifty realistic models for the effect of the muscle relaxant rocuronium in the NMB. In order to overcome modeling uncertainties a numeric self-calibration of the parameters in the MPP model nonlinearity was implemented. This step matches the anesthesiologists' mindset. The controller was extensively tested in simulation and in real cases. The good reference tracking results show the reliability of the proposed strategy and supports its use in the clinical practice.

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Section: Self-calibrationmentioning

confidence: 99%

“…Nevertheless, several control strategies exist in the literature for the control of muscle relaxants administration, namely atracurium and mivacurium [6], [7].…”

Section: Introductionmentioning

confidence: 99%