Purpose:To evaluate the performance of the autofocusing (AF) motion correction technique in high-resolution trabecular bone imaging where image signal-to noise ratio (SNR) is limited.
Materials and Methods:Raw data from 26 clinical threedimensional (3D) wrist exams were motion corrected using AF for both in-plane rotation and translation. Changes in image metrics (a measurement of image sharpness) and structural parameters subsequently computed, were used to gauge the performance of the AF algorithm, and comparisons were made with translation-only navigator-corrected results.Results: On average, AF generated images with higher image sharpness compared to the navigator echo technique. The average normalized gradient squared (NGS) metric improved by 0.40%, 0.73%, and 0.84%, respectively, following translation-only navigator, translation-only AF and combined rotation/translation AF. For all structural parameters, the rotation/translation AF resulted in an approximately two-fold greater change compared to the navigator technique.
Conclusion:The data provide evidence that errors from subtle translational and rotational motion in the structural parameters in high-resolution trabecular bone images are alleviated by AF and that the resulting improvements are superior to translation-only 2D navigator correction. OSTEOPOROSIS IS the most common degenerative disease in the elderly. There is now strong evidence that the loss of bone mass is accompanied by a decline in the three-dimensional (3D) trabecular bone network's structural integrity (1-3). However, changes in bone mineral density (BMD) in response to treatment with antiresorptive drugs are often incommensurate with the observed reduction in fracture rates (4,5). Recent advances in high-resolution microMRI provide sufficient detection sensitivity to resolve individual trabeculae at peripheral skeletal sites such as the distal radius (wrist) and tibia (ankle), therefore allowing imaging and structural analysis of the 3D trabecular network at these locations (6,7). It has been shown that the disease-related structural changes at these surrogate sites parallel similar structural changes elsewhere in the skeleton and therefore may serve as markers for disease progression or regression (8,9).A major challenge for in vivo high-resolution trabecular bone imaging is subject motion. Due to the small in-plane pixel size (ϳ140 m) and the relatively long scan time (ϳ12 minutes) required to image a 3D volume, involuntary motion could easily cause displacements of several pixels or greater, even with the use of immobilization devices. The resulting image blurring and ghosting may cause errors in the assessment of the 3D trabecular bone network and ultimately limit the usefulness of the method to predict bone strength.Several approaches have been proposed to compensate for motion artifacts in MRI. Among these, the navigator echo technique collects additional data to measure and compensate for translation and rotation (10 -12). A postprocessing technique termed autofocusing (AF) (or...