Automatic concentration and reformulation of PET tracers via microfluidic membrane distillation

Chao, Philip H.; Collins, J.M.; Argus, Joseph P.; Tseng, Wei-Yu; Lee, Jason T.; Dam, R. Michael van

doi:10.1039/c6lc01569g

Cited by 12 publications

(5 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, an effective evaporation technique concentrated the solution, leading to a rapid concentration of samples containing short-lived radiolabeled tracers. 83 Another option for an evaporative membrane entails the adoption of a dense material, such as PDMS. Microfluidic devices composed of dense material have gas-permeable walls, which permit evaporation through them (i.e., pervaporation).…”

Section: Evaporation Pervaporation and Condensation Of Solutionsmentioning

confidence: 99%

Gas transport mechanisms through gas-permeable membranes in microfluidics: A perspective

Seo,

Kim

2023

Biomicrofluidics

View full text Add to dashboard Cite

Gas-permeable membranes (GPMs) and membrane-like micro-/nanostructures offer precise control over the transport of liquids, gases, and small molecules on microchips, which has led to the possibility of diverse applications, such as gas sensors, solution concentrators, and mixture separators. With the escalating demand for GPMs in microfluidics, this Perspective article aims to comprehensively categorize the transport mechanisms of gases through GPMs based on the penetrant type and the transport direction. We also provide a comprehensive review of recent advancements in GPM-integrated microfluidic devices, provide an overview of the fundamental mechanisms underlying gas transport through GPMs, and present future perspectives on the integration of GPMs in microfluidics. Furthermore, we address the current challenges associated with GPMs and GPM-integrated microfluidic devices, taking into consideration the intrinsic material properties and capabilities of GPMs. By tackling these challenges head-on, we believe that our perspectives can catalyze innovative advancements and help meet the evolving demands of microfluidic applications.

show abstract

Section: Evaporation Pervaporation and Condensation Of Solutionsmentioning

confidence: 99%

Gas transport mechanisms through gas-permeable membranes in microfluidics: A perspective

Seo,

Kim

2023

Biomicrofluidics

View full text Add to dashboard Cite

show abstract

“…A final concentration of the product solution could be performed by solid-phase [223] and also by on-chip solid phase extraction [224]. A novel method reported the use of sweeping gas membrane distillation, in order to rapidly perform the concentration and formulation process in a fully automated microfluidic system [225].…”

Section: Microfluidic Technologymentioning

confidence: 99%

18F-labelling innovations and their potential for clinical application

Coenen

Neumaier

2018

Clin Transl Imaging

View full text Add to dashboard Cite

An impressive variety of new methodologies for the preparation of 18 F-labelled tracers and ligands has appeared over the last decade. Most strategies of the newly developed radiofluorination methods predominantly aim at products of high molar activity by 'late-stage' labelling of small (hetero)aromatic molecules and the use of transition metals. This is accompanied by the improvement of technical procedures, like preparation of reactive [ 18 F]fluoride and automated syntheses. The newly introduced procedures reflect a high innovative level and creativity in radio(pharmaceutical) chemistry at present, which are based on modern chemical methods and deep mechanistic insights. Taking also automation and quality control into consideration, major recently developed radiofluorination methods, most of those still under development, are compiled here in view of their potential for clinical PET imaging and thus the ability to advance molecular imaging.

show abstract

“…Ideally, it does not rely on cleaning procedures and aligns with the state-of-the art approach of single-use disposables. To date, efforts in this direction have focused on development of microfluidic approaches for radiopharmaceutical manufacturing (Amaraesekera et al 2013; Audrain 2007; Awasthi et al 2014; Bejot et al 2010; Bouvet et al 2011; Bouvet et al 2012; Bouvet and Wuest 2013; Chen et al 2014; Collier et al 2010, 2017; De Leonardis et al 2010, 2011; Gaja et al 2012; Gillies et al 2006; Lu and Pike 2007; Lu and Pike 2010; Elizarov 2009; Elizarov et al 2010; Fortt and Gee 2013; Kealey et al 2011; Keng et al 2012b; Keng and van Dam 2015; Lee et al 2005; Liow et al 2005; Liu et al 2011; Liu et al 2013; Lu et al 2004, 2009, 2010; Matesic et al 2017; Miller 2009; Miller et al 2010, 2011; Pascali et al 2010, 2011, 2013; Pascali and Salvadori 2016; Rensch et al 2012, 2013; Selivanova et al 2012; Simms et al 2012; Steel et al 2007; Ungersboeck et al 2011, 2012a, 2012b; Voccia et al 2009; Wang et al 2010; Wang et al 2019; Wester et al 2009; Wheeler et al 2010; Yokell et al 2012; Zeng et al 2013), as well as purification/reformulation (Chao et al 2017) and quality control (QC) testing (Ha et al 2017; Taggart et al 2016; Ly et al 2018). While the benefits of microreactors for radiopharmaceutical synthesis have been well documented in this multitude of literature precedent, and they have been used to prepare radiopharmaceuticals for clinical use (Lebedev et al 2013; Liang et al 2014a, 2014b; Rensch et al 2014), there are continuing challenges that have prevented them from commercialization and really transitioning into widespread use to date (Chiu et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Development and implementation of ISAR, a new synthesis platform for radiopharmaceutical production

Frank

Ciulli

Rensei

et al. 2019

EJNMMI radiopharm. chem.

View full text Add to dashboard Cite

Background PET radiopharmaceutical development and the implementation of a production method on a synthesis module is a complex and time-intensive task since new synthesis methods must be adapted to the confines of the synthesis platform in use. Commonly utilized single fluid bus architectures put multiple constraints on synthesis planning and execution, while conventional microfluidic solutions are limited by compatibility at the macro-to-micro interface. In this work we introduce the ISAR synthesis platform and custom-tailored fluid paths leveraging up to 70 individually addressable valves on a chip-based consumable. The ISAR synthesis platform replaces traditional stopcock valve manifolds with a fluidic chip that integrates all fluid paths (tubing) and valves into one consumable and enables channel routing without the single fluid bus constraint. ISAR can scale between the macro- (10 mL), meso- (0.5 mL) and micro- (≤0.05 mL) domain seamlessly, addressing the macro-to-micro interface challenge and enabling custom tailored fluid circuits for a given application. In this paper we demonstrate proof-of-concept by validating a single chip design to address the challenge of synthesizing multiple batches of [13N]NH3 for clinical use throughout the workday. Results ISAR was installed at an academic PET Center and used to manufacture [13N]NH3 in > 96% radiochemical yield. Up to 9 batches were manufactured with a single consumable chip having parallel paths without the need to open the hot-cell. Quality control testing confirmed the ISAR-based [13N]NH3 met existing clinical release specifications, and utility was demonstrated by imaging a rodent with [13N]NH3 produced on ISAR. Conclusions ISAR represents a new paradigm in radiopharmaceutical production. Through a new system architecture, ISAR integrates the principles of microfluidics with the standard volumes and consumables established in PET Centers all over the world. Proof-of-concept has been demonstrated through validation of a chip design for the synthesis of [13N]NH3 suitable for clinical use.

show abstract

Automatic concentration and reformulation of PET tracers via microfluidic membrane distillation

Cited by 12 publications

References 39 publications

Gas transport mechanisms through gas-permeable membranes in microfluidics: A perspective

Gas transport mechanisms through gas-permeable membranes in microfluidics: A perspective

18F-labelling innovations and their potential for clinical application

Development and implementation of ISAR, a new synthesis platform for radiopharmaceutical production

Contact Info

Product

Resources

About