Automatic Atlas-Based Volume Estimation of Human Brain Regions from MR Images

Andreasen, Nancy C.; Rajarethinam, Rajaprabhakaran; Cizadlo, Theodore; Arndt, Stephan; Swayze, Victor W.; Flashman, Laura A.; O'Leary, Daniel S.; Ehrhardt, James C.; Yuh, William T. C.

doi:10.1097/00004728-199601000-00018

Cited by 294 publications

(197 citation statements)

References 31 publications

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“…MRIs were acquired at the University of Wisconsin and were processed using a semiautomated software package, that is, Brain Research: Analysis of Images, Networks, and Systems (BRAINS 2; Andreasen et al, 1996;Harris et al, 1999). For the current study, neuroimaging analyses were conducted blinded to group status and clinical 0 sociodemographic characteristics of the subjects.…”

Section: Mri Protocolmentioning

confidence: 99%

“…Manual inspection and correction of the output of the neural network tracing was conducted. The BRAINS2 software and procedures have been shown to be of high inter-rater reliability, intrarater reliability, and scan-rescan reproducibility (Andreasen et al, 1996;Harris et al, 1999;Magnotta et al, 1999aMagnotta et al, , 2002. MRI regions of interest for this investigation included the hippocampus and thalamus.…”

Section: Mri Protocolmentioning

confidence: 99%

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Thalamic atrophy and cognition in unilateral temporal lobe epilepsy

Seidenberg

Hermann

Pulsipher

et al. 2008

J Inter Neuropsych Soc

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This study examined quantitative magnetic resonance volumes of the thalamus and hippocampus and determined their relationship with cognitive function and clinical seizure characteristics in a sample of 46 unilateral temporal lobe epilepsy (TLE) subjects (20 left and 26 right) and 29 controls. The hippocampus and thalamus exhibited different patterns of volume abnormality, different associations with clinical seizure characteristics, and different patterns of relationship with cognitive measures. Hippocampal volume reduction was primarily ipsilateral to the seizure focus, and thalamic volume reduction was bilateral. Ipsilateral hippocampal volume was significantly correlated with both early neurodevelopmental features (age of seizure onset) and disease characteristics (duration of epilepsy), whereas thalamus integrity was related only to disease variables. Hippocampal volume showed a selective association with verbal memory performance. In contrast, both left and right thalamic volumes were significantly correlated with performance on both memory and nonmemory cognitive domains. These findings underscore the importance of thalamic atrophy in chronic TLE and its potential implications for cognition. (JINS, 2008, 14, 384-393.)

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Section: Mri Protocolmentioning

confidence: 99%

Section: Mri Protocolmentioning

confidence: 99%

Thalamic atrophy and cognition in unilateral temporal lobe epilepsy

Seidenberg

Hermann

Pulsipher

et al. 2008

J Inter Neuropsych Soc

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“…75 These images were then subjected to a linear transformation into standardized stereotaxic Talairach atlas space 76 to generate automated measurements of frontal, temporal, parietal, and occipital lobes, cerebellum, and subcortical regions. 77 To further classify tissue volumes into gray matter (GM), white matter (WM) and cerebrospinal fluid (CSF), we employed a discriminant analysis method of tissue segmentation based on automated training class selection that utilized data from the T1, T2 and PD sequences. 78 In this study, we examined frontal lobe GM, WM and CSF volumes.…”

Section: Mri Acquisition and Image Processingmentioning

confidence: 99%

Catechol-O-methyl transferase Val158Met gene polymorphism in schizophrenia: working memory, frontal lobe MRI morphology and frontal cerebral blood flow

et al. 2005

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The catechol-O-methyl transferase (COMT) gene is considered a leading schizophrenia candidate gene. Although its role in increasing schizophrenia susceptibility has been conflicting, recent studies suggest the valine allele may contribute to poor cognitive function in schizophrenia. V 158 M COMT genotype was obtained on 159 schizophrenia patients and 84 healthy controls. The effects of COMT genotype on four measures of working memory/ executive functions (Wisconsin Card Sorting, digit span backward, Trail Making and N-back tests) and on MRI frontal brain volumes were examined. Genotype distributions were not significantly different between patients and controls. There were no significant genotype or genotype-by-group effects on any working memory/executive function measures. No genotype or genotype-by-diagnosis interaction effects were found with MRI frontal lobe volumes. Randomization analyses using [ 15 O]H 2 O positron emission tomography (PET) cerebral blood flow data found Val/Val patients had higher frontal lobe activation than Met/Met patients while performing the one-back task. Overall, these findings do not support a major role for COMT in increasing susceptibility for schizophrenia or in mediating frontal lobe function. Age-related changes and phenotypic heterogeneity of schizophrenia may influence the complex relationships between COMT genotype and cognition.

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“…The image was re-sampled to this new orientation and re-sliced to an isotropic resolution of 1.0 mm. Automated Talairach-regionbased structure identification for definition of major brain regions, including frontal, temporal, parietal, occipital, subcortical, ventricles, and cerebellum, was conducted (Andreasen et al, 1996). This method relies on a piecewise linear transformation of the Talairach grid onto the area of interest.…”

Section: Anatomical Mri and Morphometric Proceduresmentioning

confidence: 99%

Aging: Compensation or maturation?

Aine

Woodruff²,

Knoefel

et al. 2006

NeuroImage

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Neuroimaging studies of healthy aging often reveal differences in neural activation patterns between young and elderly groups for episodic memory tasks, even though there are no differences in behavioral performance. One explanation typically offered is that the elderly compensate for their memory deficiencies through the recruitment of additional prefrontal regions. The present study of healthy aging compared magnetoencephalographic (MEG) time-courses localized to specific cortical regions in two groups of subjects (20-29 years and ≥65 years) during a visual delayed-match-to-sample (DMS) task. MR morphometrics and neuropsychological test results were also examined with the hope of providing insight into the nature of the age-related differences. The behavioral results indicated no differences in performance between young and elderly groups. Although there was a main effect of age on the latency of the initial peak in primary/secondary visual cortex, these longer latencies were not correlated with the performance of elderly on the DMS task. The lateral occipital gyrus (LOG) revealed qualitatively different patterns of activity for the two age groups corroborated by neuropsychological test results. Morphometric results for the young versus elderly groups revealed less white (WM) and gray matter (GM) volumes in the frontal lobes of the elderly. When a group of middle-aged subjects (33-43 years) was included in the morphometric analyses, the middle-aged subjects revealed statistically greater WM volumes in frontal and parietal cortex suggesting immature WM tracts in the young. Perhaps our elderly utilized a different strategy compared to the young due to the different brain maturation levels of these groups.

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Automatic Atlas-Based Volume Estimation of Human Brain Regions from MR Images

Cited by 294 publications

References 31 publications

Thalamic atrophy and cognition in unilateral temporal lobe epilepsy

Thalamic atrophy and cognition in unilateral temporal lobe epilepsy

Catechol-O-methyl transferase Val158Met gene polymorphism in schizophrenia: working memory, frontal lobe MRI morphology and frontal cerebral blood flow

Aging: Compensation or maturation?

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