“…Retinal fundus photographs have been widely used by clinicians to diagnose and monitor many ocular diseases including glaucoma, pathological myopia, age-related macular degeneration, and diabetic retinopathy. Since manual assessment of the images is tedious, expensive and subjective, computer aided diagnosis methods [1] have been developed to analyse the images automatically for optic disc segmentation [2]- [5], Manuscript optic cup segmentation or cup to disc ratio assessment [6]- [9], retinal vessel detection [10], [11], glaucoma detection [12], [13], diabetic retinopathy detection [14], [15], age-related macular degeneration detection [16]- [19], and pathological myopia detection [20]. Image quality is an essential factor for proper development and validation of the algorithms [21].…”