Automated Volumetric Analysis of Postoperative Magnetic Resonance Imaging Predicts Survival in Patients with Glioblastoma

Кривошапкин, А. Л.; Сергеев, Г. С.; Gaitán, Armando; Kalneus, Leonid E.; Kurbatov, Vladislav P.; Abdullaev, Orkhan; Salim, Nidal; Bulanov, D; Simonovich, A.E.

doi:10.1016/j.wneu.2019.03.142

Cited by 9 publications

(6 citation statements)

References 18 publications

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“…A single, short session can permit delivery of it prescribed single focal dose equivalent to multiple sessions of fractionated external irradiation, while also minimizes radiation dose to the neighboring healthy tissue. [ 22 ] The objective of the following pilot study was to assess the clinical benefit of combining repeat resection of recurrent GBM with IBEB.…”

Section: Introductionmentioning

confidence: 99%

Prospective comparative study of intraoperative balloon electronic brachytherapy versus resection with multidisciplinary adjuvant therapy for recurrent glioblastoma

Кривошапкин

Gaitán

Abdullaev³

et al. 2021

Surgical Neurology International

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Background: Intraoperative balloon electronic brachytherapy (IBEB) may provide potential benefit for local control of recurrent cerebral glioblastomas (GBMs). Methods: This is a preliminary report of an open-label, prospective, comparative cohort study conducted in two neurosurgical centers with ongoing follow-up. At recurrence, patients at one center (n = 15) underwent reresection with IBEB while, at the second center (n = 15), control subjects underwent re-resection with various accepted second-line adjuvant chemoradiotherapy options. A comparative analysis of overall survival (OS) and local progression-free survival (LPFS) following re-resection was performed. Exploratory subgroup analysis based on postoperative residual contrast-enhanced volume status was also done. Results: In the IBEB group, median LPFS after re-resection was significantly longer than in the control group (8.0 vs. 6.0 months; log rank χ2 = 4.93, P = 0.026, P < 0.05). In addition, the median OS after second resection in the IBEB group was also significantly longer than in the control group (11.0 vs. 8.0 months; log rank χ2 = 4.23, P = 0.04, P < 0.05). Conclusion: These hypothesis-generating results from a small cohort of subjects suggest putative clinical benefit in OS and LPFS associated with maximal safe re-resection of recurrent GBM with IBEB versus re-resection and standard adjuvant therapy, a hypothesis that deserves further testing in an appropriately powered clinical trial.

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Section: Introductionmentioning

confidence: 99%

Prospective comparative study of intraoperative balloon electronic brachytherapy versus resection with multidisciplinary adjuvant therapy for recurrent glioblastoma

Кривошапкин

Gaitán

Abdullaev³

et al. 2021

Surgical Neurology International

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“…Among fully automated approaches for residual tumour segmentation, Meier et al 25 used an end-to-end machine learning based algorithm with a performance comparable to a human rater. Krivoshapkin et al 57 used an automated tool based on a mathematical model and showed that automatically measured residual tumour burden was a significant predictor of OS ( p -value < 0.001). While our analysis did not involve segmentation, we were able to demonstrate the high performance of MET-PET in detecting residual tumour.…”

Section: Discussionmentioning

confidence: 99%

Radiomics for residual tumour detection and prognosis in newly diagnosed glioblastoma based on postoperative [11C] methionine PET and T1c-w MRI

Shahzadi,

Seidlitz,

Beuthien-Baumann

et al. 2024

Sci Rep

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Personalized treatment strategies based on non-invasive biomarkers have potential to improve patient management in patients with newly diagnosed glioblastoma (GBM). The residual tumour burden after surgery in GBM patients is a prognostic imaging biomarker. However, in clinical patient management, its assessment is a manual and time-consuming process that is at risk of inter-rater variability. Furthermore, the prediction of patient outcome prior to radiotherapy may identify patient subgroups that could benefit from escalated radiotherapy doses. Therefore, in this study, we investigate the capabilities of traditional radiomics and 3D convolutional neural networks for automatic detection of the residual tumour status and to prognosticate time-to-recurrence (TTR) and overall survival (OS) in GBM using postoperative [11C] methionine positron emission tomography (MET-PET) and gadolinium-enhanced T1-w magnetic resonance imaging (MRI). On the independent test data, the 3D-DenseNet model based on MET-PET achieved the best performance for residual tumour detection, while the logistic regression model with conventional radiomics features performed best for T1c-w MRI (AUC: MET-PET 0.95, T1c-w MRI 0.78). For the prognosis of TTR and OS, the 3D-DenseNet model based on MET-PET integrated with age and MGMT status achieved the best performance (Concordance-Index: TTR 0.68, OS 0.65). In conclusion, we showed that both deep-learning and conventional radiomics have potential value for supporting image-based assessment and prognosis in GBM. After prospective validation, these models may be considered for treatment personalization.

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“…В рамках третьего этапа (дополнительная модификация инструмента) была определена финальная версия вопросов с позиции клинического объединения схожих вопросов и оценки статистической валидации (допустимости) такого объединения. В основе математического анализа лежало вычисление (по показателю АС/СО) между сходными вопросами коэффициента корреляции Пирсона с последующей качественной оценкой полученных коэффициентов на основе шкалы Чеддока (показателя тесноты связи) [16]. Полученные данные показали, что в одном из 8 случаев объединение вопросов не представлялось возможным, в остальных случаях объединение позволило сформировать финальную версию оценки КЖ пациента при КЗС, включающую 22 вопроса.…”

Section: результатыunclassified

Methodological Principles for the Development of a Questionnaire “Quality of Life” in Patients with Computer Visual Syndrome

Овечкин¹,

Yudin

Kovrigina³

et al. 2021

Oftalʹmologiâ

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Purpose: scientific substantiation and development of methodological principles of the “quality of life” (QOL) assessment questionnaire in patients with symptoms of computer visual syndrome (CVS).Material and мethods. As part of the first stage of the study, an individual interview was carried out (according to the standard developed methodology) with 100 patients with visually strenuous labor, according to the results of which the entire spectrum of complaints arising during prolonged work with a computer was determined (44 complaints in total). As part of the second stage, a special questionnaire was developed, in which the identified complaints were transformed into questions. The study involved 96 ophthalmologists aged 32 to 62 years with an average of 17.3 ± 1.4 years. The task of an expert ophthalmologist was to assess the relevance each of the questions in terms of the influence degree on the patient’s QOL, as well as the “severity” of the complaint in terms the of occurrence frequency.Results. The development of the questionnaire was based on the sequential implementation of five stages (development of a conceptual framework; development of a preliminary version and confirmation of validity content; additional modification; scaling procedure development; psychometric properties determination). The results obtained made it possible to form the questionnaire (22 questions) the final version, which (according to the analysis) meets the requirements of meaningful and constructive validity (specificity, reflection of questions and scales of significance for the patient, the results of an expert assessment by ophthalmologists of the psychometric response scale) with the weight coefficients development, the required values correlation coefficients (according to Pearson) between the relevance assessment of the question from the points according to the symptom severity, as well as the high level of consistency according to the “Cronbach-α” indicator.Conclusion. The main direction of the assessment QOL improving of a patient with GLC is active participation in the ophthalmologist’s questionnaire development. Our results determine that the expert assessment provides a mathematically confirmed choice of the most significant (in terms on QoL impact) subjective manifestations, which (in conjunction with the development of each patient’s possible responses expert assessments, in points) provides the required level of the questionnaire meaningful and constructive validity. The developed questionnaire can be recommended for further clinical testing.

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Automated Volumetric Analysis of Postoperative Magnetic Resonance Imaging Predicts Survival in Patients with Glioblastoma

Cited by 9 publications

References 18 publications

Prospective comparative study of intraoperative balloon electronic brachytherapy versus resection with multidisciplinary adjuvant therapy for recurrent glioblastoma

Prospective comparative study of intraoperative balloon electronic brachytherapy versus resection with multidisciplinary adjuvant therapy for recurrent glioblastoma

Radiomics for residual tumour detection and prognosis in newly diagnosed glioblastoma based on postoperative [11C] methionine PET and T1c-w MRI

Methodological Principles for the Development of a Questionnaire “Quality of Life” in Patients with Computer Visual Syndrome

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