Automated Volume Determination of the Liver and Spleen from Tc-99m Colloid SPECT Imaging Quantification of the Liver Functional and Nonfunctional Tissue in Disease

Kavanagh, G. J.; Kavanagh, Joseph; Kavanagh, Paul; Irwin, Lowell; Perkins, Alan C.; Swanson, Leonard A.

doi:10.1097/00003072-199007000-00009

Cited by 7 publications

(4 citation statements)

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“…Splenic volume has been measured using single photon emission computed tomography (SPECT; Strauss et al, 1984;Van Heertum et al, 1987;Kavanagh et al, 1990) and computed tomography (CT; Henderson et al, 1981;Breiman et al, 1982;Cools et al, 1983;Prassopoulos et al, 1997). Henderson et al (1981) and Breiman et al (1982) described the application of planimetry for the estimation of splenic volume from CT. Planimetry involves the manual tracing of the splenic boundary in sectional profiles and calculating the area enclosed by the boundary.…”

Section: Introductionmentioning

confidence: 99%

Postprandial decrease in splenic volume demonstrated by magnetic resonance imaging and stereology

et al. 2000

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Section: Introductionmentioning

confidence: 99%

Postprandial decrease in splenic volume demonstrated by magnetic resonance imaging and stereology

et al. 2000

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“…A phase 1 trial with a 3 + 3 design was conducted to evaluate the safety of comprehensive ablative radiotherapy to liver disease using more aggressive functional nontarget liver radiation dose constraints with each level. Eligibility criteria included 1) a diagnosis of hepatocellular carcinoma, intrahepatic cholangiocarcinoma (iCCA), or liver metastasis (LM); 2) prior treatment with irinotecan or oxaliplatin chemotherapy or liver resection; and 3) a minimum functional liver volume of 400 cc as estimated by SPECT using a threshold of 40% maximum intensity ( 16 , 17 ). Patients with cirrhosis, prior liver-directed radiotherapy, or prior Yttrium-90 therapy were excluded.…”

Section: Methodsmentioning

confidence: 99%

“…A nuclear medicine physician estimated functional liver per SPECT based on a 40% maximum intensity threshold of uptake within the liver, excluding the spleen. This threshold has been established for estimating functional liver volume in prior studies ( 16 , 17 ). A contour of the functional liver was generated and registered to the treatment planning CT scan (see Figure 1 ).…”

Section: Methodsmentioning

confidence: 99%

Phase I trial of single-photon emission computed tomography–guided liver-directed radiotherapy for patients with low functional liver volume

Chang,

Wong,

Chasen

et al. 2024

JNCI Cancer Spectrum

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Background Traditional constraints specify that 700 cc of liver should be spared a hepatotoxic dose when delivering liver-directed radiotherapy to reduce the risk of inducing liver failure. We investigated the role of single photon emission computed tomography (SPECT) to identify and preferentially avoid functional liver during liver-directed radiation treatment planning in patients with preserved liver function but limited functional liver volume after receiving prior hepatotoxic chemotherapy or surgical resection. Methods This phase I trial with a 3 + 3 design evaluated the safety of liver-directed radiotherapy using escalating functional liver radiation dose constraints in patients with liver metastases. Dose limiting toxicities (DLTs) were assessed 6-8 weeks and 6 months after completing radiotherapy. Results All twelve patients had colorectal liver metastases and received prior hepatotoxic chemotherapy. Eight patients underwent prior liver resection. Median computed tomography (CT) anatomical non-tumor liver volume was 1,584 cc (range 764-2,699 cc). Median SPECT functional liver volume was 1,117 cc (range 570-1,928cc). Median non-target CT and SPECT liver volumes below the volumetric dose constraint were 997 cc (range 544-1,576 cc) and 684 cc (range 429-1,244 cc), respectively. The prescription dose was 67.5-75 Gy in 15 fractions or 75-100 Gy in 25 fractions. No DLTs were observed during follow-up. One-year in-field control was 57%. One-year overall survival was 73%. Conclusion Liver-directed radiotherapy can be safely delivered to high doses when incorporating functional SPECT into the radiation treatment planning process which may enable sparing of lower volumes of liver than traditionally accepted in patients with preserved liver function. Trial Registration NCT02626312

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“…To assess the presence of red blood cells within the mass, the patient underwent a blood pool scintigraphy performed after an intravenous administration of autologous 99mTc-labcllcd (740 MBq) red blood cells [11], Five days later, the patient underwent a scinti graphy with 99mTc phvtale (340 MBq). SPECT imaging was per formed using a single-head gamma camera (GE Starcam 2000.…”

Section: Case Reportmentioning

confidence: 99%

Scintigraphic Imaging of Hepatic Epithelioid Hemangioendothelioma

Gianni¹,

Vincentis

Graziano

et al. 1997

Digestion

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The epithelioid hemangioendothelioma of the liver has been recently characterized as a rare tumor with distinctive pathological features affecting young adults. Our report describes a case of histologically confirmed primary epithelioid hemangioendothelioma of the liver, diagnosed by clinical examination as well as radiological (CT/MR) and scintigraphic imaging (labelled red cells/ phytate-SPECT). This case highlights the usefulness of nuclear medicine techniques during the diagnostic of this rare tumor. Further it stresses the possibility of employing an easy and noninvasive method to adequately follow-up those patients who cannot be considered as disease-free even after orthotopic liver transplantation because of the recurrence of the disease in the transplanted liver.

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Automated Volume Determination of the Liver and Spleen from Tc-99m Colloid SPECT Imaging Quantification of the Liver Functional and Nonfunctional Tissue in Disease

Cited by 7 publications

References 0 publications

Postprandial decrease in splenic volume demonstrated by magnetic resonance imaging and stereology

Postprandial decrease in splenic volume demonstrated by magnetic resonance imaging and stereology

Phase I trial of single-photon emission computed tomography–guided liver-directed radiotherapy for patients with low functional liver volume

Scintigraphic Imaging of Hepatic Epithelioid Hemangioendothelioma

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