Automated Talairach Atlas labels for functional brain mapping

Abstract

An automated coordinate‐based system to retrieve brain labels from the 1988 Talairach Atlas, called the Talairach Daemon (TD), was previously introduced [Lancaster et al., 1997]. In the present study, the TD system and its 3‐D database of labels for the 1988 Talairach atlas were tested for labeling of functional activation foci. TD system labels were compared with author‐designated labels of activation coordinates from over 250 published functional brain‐mapping studies and with manual atlas‐derived labels from an expert group using a subset of these activation coordinates. Automated labeling by the TD system compared well with authors' labels, with a 70% or greater label match averaged over all locations. Author‐label matching improved to greater than 90% within a search range of ±5 mm for most sites. An adaptive grey matter (GM) range‐search utility was evaluated using individual activations from the M1 mouth region (30 subjects, 52 sites). It provided an 87% label match to Brodmann area labels (BA 4 & BA 6) within a search range of ±5 mm. Using the adaptive GM range search, the TD system's overall match with authors' labels (90%) was better than that of the expert group (80%). When used in concert with authors' deeper knowledge of an experiment, the TD system provides consistent and comprehensive labels for brain activation foci. Additional suggested applications of the TD system include interactive labeling, anatomical grouping of activation foci, lesion‐deficit analysis, and neuroanatomy education. Hum. Brain Mapping 10:120–131, 2000. © 2000 Wiley‐Liss, Inc.

Effects of Acute Tryptophan Depletion on Mood and Facial Emotion Perception Related Brain Activation and Performance in Healthy Women with and without a Family History of Depression

“…Due to the key role of the amygdala in emotion, ROI analyses for the left and right amygdala were performed for all contrasts. These ROIs were based on the Talairach Daemon database (Lancaster et al, 2000), which was also used to determine anatomical labels for the specific Talairach coordinates. Based on the study performed by Winston et al (2003), who used exactly the same task in healthy volunteers, specific ROIs were defined for the different contrasts.…”

Spatio‐temporal distribution of brain activity associated with audio‐visually congruent and incongruent speech and the McGurk Effect

“…2001), with the three‐dimensional solution space restricted to cortical gray matter, as determined by the probabilistic Talairach atlas (Lancaster et al. 2000). The standard electrode positions on the MNI152 scalp were used (Oostenveld and Praamstra 2001; Jurcak et al.…”

‘O’ blood type is associated with larger grey-matter volumes in the cerebellum

“…Only clusters surviving a Family-Wise Errorcorrected p < 0.05 were reported as significant. Peak Montreal National Institute coordinates were converted to Talairach space using a nonlinear transform (imaging.mrccbu.cam.ac.uk/downloads/MNI2tal/mni2tal-m), and the Talaraich Daemon client was used for the purpose of interpretation (Lancaster et al, 2000). According to the null hypothesis, no voxel-based difference in GM was expected.…”