Automated synthesis of [11C]-(+)-PHNO from [11C]methyl iodide

Garcia-Arguello, Segundo Francisco; Årstad, Erik; Brickute, Diane; Luthra, Sajinder K.; Turton, David R.; Glaser, Matthias; Fortt, Robin; Robins, Edward G.

doi:10.1016/j.neuroimage.2010.04.177

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Agonist Radioligands For the D 2 /D 3 Receptors1

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“…[ 11 C]PHNO has already been used in clinical studies evaluating D 3 receptor function in neurologic and psychiatric disorders 19,106 . An optimization of labelling strategy is ongoing and may further advance the use of [ 11 C]PHNO 60,89 .…”

Section: Agonist Radioligands For the D 2 /D 3 Receptorsmentioning

confidence: 99%

Fenfluramine‐induced serotonin release decreases [¹¹C]AZ10419369 binding to 5‐HT_1B‐receptors in the primate brain

Finnema

Varrone

Hwang

et al. 2010

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The need for positron emission tomography (PET)-radioligands that are sensitive to changes in endogenous serotonin (5-HT) levels in brain is recognized in experimental and clinical psychiatric research. We recently developed the novel PET radioligand [(11)C]AZ10419369 that is highly selective for the 5-HT(1B) receptor. In this PET-study in three cynomolgus monkeys, we examined the sensitivity of [(11)C]AZ10419369 to altered endogenous 5-HT levels. Fenfluramine-induced 5-HT release decreased radioligand binding in a dose-dependent fashion with a regional average of 27% after 1 mg/kg and 50% after 5 mg/kg. This preliminary study supports that [(11)C]AZ10419369 is sensitive to endogenous 5-HT levels in vivo and may serve as a tool to examine the pathophysiology and treatment of major psychiatric disorders.

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Section: Agonist Radioligands For the D 2 /D 3 Receptorsmentioning

confidence: 99%

Fenfluramine‐induced serotonin release decreases [¹¹C]AZ10419369 binding to 5‐HT_1B‐receptors in the primate brain

Finnema

Varrone

Hwang

et al. 2010

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References: 1986–2011

2012

FESTSCHRIFT the Institute of Nuclear Medicine 50 Years

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Automated synthesis of [11C]-(+)-PHNO from [11C]methyl iodide

Cited by 2 publications

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Fenfluramine‐induced serotonin release decreases [¹¹C]AZ10419369 binding to 5‐HT_1B‐receptors in the primate brain

Fenfluramine‐induced serotonin release decreases [¹¹C]AZ10419369 binding to 5‐HT_1B‐receptors in the primate brain

References: 1986–2011

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Automated synthesis of [11C]-(+)-PHNO from [11C]methyl iodide

Cited by 2 publications

References 0 publications

Fenfluramine‐induced serotonin release decreases [11C]AZ10419369 binding to 5‐HT1B‐receptors in the primate brain

Fenfluramine‐induced serotonin release decreases [11C]AZ10419369 binding to 5‐HT1B‐receptors in the primate brain

References: 1986–2011

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Fenfluramine‐induced serotonin release decreases [¹¹C]AZ10419369 binding to 5‐HT_1B‐receptors in the primate brain

Fenfluramine‐induced serotonin release decreases [¹¹C]AZ10419369 binding to 5‐HT_1B‐receptors in the primate brain