Automated robotic vitrification of embryos

Study Question: What are the good practices for the use of ADD-ON Treatments in IVF cycles in INDIA? What is Already Known: Add on treatments in IVF are procedures and technologies which are offered to patients in hope of improving the success rates. A lot of add on treatments exist; most of them have limited evidence and data for the Indian patient population is miniscule. These interventions may have limited effects, so it is imperative that any new technology that is offered is evaluated properly and has enough evidence to suggest that it is safe and effective. Study Design, Size, Duration: This is the report of a 2-day consensus meeting where two moderators were assigned to a group of experts to collate information on Add on treatments in IVF in INDIA. This meeting utilised surveys, available scientific evidence and personal laboratory experience into various presentations by experts on pre-decided specific topics. Participants/Materials, Setting, Methods: Expert professionals from ISAR representing clinical and embryology fields. Main Results and the Role of Chance: The report is divided in various components including the health of the Offspring, the various ADD ons available to an ART center, consensus points for each technology & qualifications and trainings for embryologists, the report and recommendations of the expert panel reflect the discussion on each of the topics and try to lay down good practice points for labs to follow. Limitations, Reasons for Caution: The recommendations are solely based on expert opinion. Future availability of data may warrant an update of the same. Wider Implications of the Findings: These guidelines can help labs across the country to standardise their ART services and improve clinical outcomes, it will also motivate clinics to collect data and report the use of Add ons to the national registry. Study Funding/Competing Interest(S): The consensus meeting and writing of the paper was supported by funds from CooperSurgical India.

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“…Due to poor reproducibility and inconsistency across operators, the success and survival rates also vary significantly. [ 39 ]…”

Section: Vitrificationmentioning

confidence: 99%

ISAR consensus guidelines on add-ons treatment in in vitro fertilization

Malhotra¹,

Malhotra²,

Kamat

et al. 2021

J Hum Reprod Sci

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“…For the first case, the end-effector of a micromanipulator has a mechanical arm connecting it to its base. This type of micromanipulator includes lead-screw driving stages and piezoelectric actuators [1,2,3]. However, the mechanical connection produces frictions, vibration, and backlash that degrade the performance of micromanipulation.…”

Section: Introductionmentioning

confidence: 99%

Modeling and Motion Control of a Magnetically Navigated Microrobotic System

Zhang

Khamesee

2016

Proceedings of the 3rd International Conference of Control, Dynamic Systems, and Robotics (CDSR'16)

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-This paper presents a technology for remotely navigating a magnetized microrobot in three-degree-of-freedom (3-DOF) using magnetic energy. The magnetic energy source is a magnetic drive unit that consists of six iron-core electromagnets, a soft-iron yoke, and a soft-iron pole-piece. The dynamic models of the magnetically navigated microrobot were derived from the magnetic field model in the workspace. An experimental method was applied to define the magnetic field model. Based on the derived dynamic models, a feed-forward plus standard PID controller was used to control the motion of the microrobot with 3-DOF. Experiment was conducted to validate the performance of the proposed controller. The experimental results showed 20µm motion accuracy in 3-DOF in a motion range of 10 × 10 × 30mm 3 .Keywords: Magnetic navigation, Microrobot, Magnetic field, PID plus feedforward controller IntroductionMicromanipulation involves performing tasks using macro scale end-effectors that have micro motion accuracy, and using micro scale end-effectors directly. For the first case, the end-effector of a micromanipulator has a mechanical arm connecting it to its base. This type of micromanipulator includes lead-screw driving stages and piezoelectric actuators [1,2,3]. However, the mechanical connection produces frictions, vibration, and backlash that degrade the performance of micromanipulation. For the second case, an end-effector is remotely manipulated without any mechanical connection to the base of a micromanipulator. This type of micromanipulator is capable of working in hazard and out-of-reach environments. Magnetic levitation micromanipulators, having remotely manipulated micro end-effector and micrometer motion accuracy, are most frequently studied and have promising potential in biomedical applications [4,5,6,7,8].Active magnetic navigation of a microrobot requires a controlled magnetic field source. Generally, electromagnets are used for multi-dimensional manipulation of a microrobot [9,10,11,12]. The magnetic field generated by electromagnets is controlled by a current. The multi-degree of motion freedom of a robot is achieved by setting up special configurations of multi-electromagnets. Since the strength of the magnetic field decays rapidly as the distance from electromagnet increases, an iron-core is commonly used to significantly enhance the magnetic field strength outside the electromagnet. This enhanced magnetic field can then expand the workspace of the microrobot.Modeling the magnetic field in the microrobots workspace is crucial to developing a magnetic navigation system. For systems that have air-core coils and permanent magnets produced magnetic field, analytical methods such as Bio-Savart Law and Amperes Law are applied to find a closed-form magnetic field model. However, for systems that have iron-core electromagnets produced magnetic field, the iron results in high nonlinearity in the whole system. Therefore, it is difficult to find a closed-form for modeling the magnetic field in the workspace. Al...

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Automation, Artificial Intelligence and Innovations in the Future of IVF

Varghese

Siristatidis

2019

In Vitro Fertilization

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Automated robotic vitrification of embryos

Cited by 4 publications

References 16 publications

ISAR consensus guidelines on add-ons treatment in in vitro fertilization

ISAR consensus guidelines on add-ons treatment in in vitro fertilization

Modeling and Motion Control of a Magnetically Navigated Microrobotic System

Automation, Artificial Intelligence and Innovations in the Future of IVF

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