Automated Quantitative Analysis of Retinal Microvasculature in Normal Eyes on Optical Coherence Tomography Angiography

Lupidi, Marco; Coscas, Florence; Cagini, Carlo; Fiore, Tito; Spaccini, Elisa; Fruttini, Daniela; Coscas, G.

doi:10.1016/j.ajo.2016.06.008

Cited by 97 publications

(90 citation statements)

References 36 publications

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“…Nevertheless, we are aware that the lateral resolution (6 lm) and sampling intervals of the 158 3 108 area (11 lm) associated with the maximum intensity projection algorithm, might result a potential overestimation of the VD. 34 Other limitations may be related to the inhomogeneity of the study patients, some of whom had actual subretinal exudation (even if outside the analyzed area) while others had only history of active disease. Furthermore, some of them had been treated in the past with PDT or had taken corticosteroids.…”

Section: Discussionmentioning

confidence: 99%

“…Detailed features of the OCT-A system have been previously described. 34 A high resolution OCT-A volume scan of 15 3 108 (approximately 4.5 3 3 mm) centered in foveal area was acquired in each enrolled subject. The volume scan was made by 261 B-scans, and the automated averaging process was set at 35 frames per scan (distance between two consecutive B-scans of 11 lm).…”

Section: Oct-angiography System Setupmentioning

confidence: 99%

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Choroidal Vascular Reactivity in Central Serous Chorioretinopathy

Piccolino

Lupidi

Cagini

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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METHODS. For this multicenter, observational, case-control study, we enrolled 35 patients with an established diagnose of CSCR and 25 age-matched healthy controls. All subjects underwent a handgrip isometric exercise to obtain elevation of blood pressure (BP). In the resting phase and during the physical effort, macular OCT-angiograms were acquired. Systemic hemodynamic data were recorded at baseline and during stress conditions using an electronic sphygmomanometer. The analysis of vascular density (VD) of the choriocapillaris (CC) was performed on OCT-angiograms. The results obtained in CSCR patients, both at baseline and during the stress test, were compared with those of healthy subjects. RESULTS.Baseline and under stress values of systolic BP, diastolic BP, and mean arterial pressure were significantly higher (P < 0.05) in CSCR patients compared to controls, reaching values in the range of hypertension during the exercise. Baseline VD values of the CC were significantly lower (P < 0.05) in CSCR cases compared to healthy subjects. We noticed a significant increase (P < 0.05) in these values under stress condition in CSCR patients and not in controls.CONCLUSIONS. The present study suggests that choroidal blood flow is dysregulated in CSCR. During physical stress, CSCR patients easily reach critical values of BP that are not dampened by compensatory mechanisms in the choroidal vessels, as it happens in healthy subjects. The CC in CSCR could be particularly vulnerable to variations of systemic hemodynamics.

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Section: Discussionmentioning

confidence: 99%

Section: Oct-angiography System Setupmentioning

confidence: 99%

Choroidal Vascular Reactivity in Central Serous Chorioretinopathy

Piccolino

Lupidi

Cagini

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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“…A volume scan of 15 × 10° (4.5 × 3 mm approx.) centered in the macular area was obtained with 261 B-scans (35 frames per scan at a distance of 11 μm each) in all OCT-A examinations [16] . Axial and lateral resolutions were 3.9 μm axial and 6 μm, respectively, both in structural B-scans and OCT angiograms: the high axial resolution was important to differentiate decorrelated vascular structures at different depths considering the short distance between the superficial (SCP) and deep capillary plexuses (DCP) [17] .…”

Section: Oct-a Image Acquisitionmentioning

confidence: 99%

Retinal Microvasculature in Nonproliferative Diabetic Retinopathy: Automated Quantitative Optical Coherence Tomography Angiography Assessment

Lupidi

Coscas

et al. 2017

Ophthalmic Res

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Purpose: To perform a qualitative and quantitative assessment of the foveal microvasculature in eyes with diabetic maculopathy using optical coherence tomography angiography (OCT-A). Methods: Retrospective case series of 48 eyes with diabetic maculopathy and 47 healthy eyes evaluated by Spectralis OCT-A. Perifoveal arcade disruptions, linear vascular dilations, microaneurysms, intraretinal microvascular abnormalities and flow-void areas were qualitatively analyzed on OCT angiograms both for the superficial (SCP) and deep (DCP) capillary plexuses. A fully automated microstructural analysis of the foveal avascular zone (FAZ) metrics, vascular and avascular surfaces was performed. Quantitative values from diabetic patients were compared with those of healthy subjects. Results: A moderate agreement between SCP and DCP in terms of diabetes-induced vascular lesions in the qualitative assessment was shown. The comparative quantitative analysis between SCP and DCP in diabetic patients revealed a statistically significant difference (p < 0.05) in terms of FAZ perimeter and FAZ surface. No statistically significant difference was shown in total vascular and avascular surfaces. A statistically significant difference between the diabetic and control groups was noticed both for SCP and DCP considering FAZ metrics and vascular surfaces. Conclusions: A qualitative and quantitative OCT-A approach on retinal vascular perfusion may offer an objective and reliable method for monitoring disease progression in diabetic retinopathy.

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“…Since the ICP is qualitatively and functionally distinct from the SCP and the DCP, a potential relevance of the ICP for clarifying the origin of middle retinal ischemic entities has been reported, therefore providing new insight into diabetic retinopathy (DR) [10]. Nevertheless, several concerns about the capability of the current OCT-A technologies to differentiate the ICP from the DCP have been raised [11, 12]. These are mainly due to failures in segmentation strategies and shadowgraphic artifacts, which cause the projection of the SCP onto the ICP and the DCP.…”

Section: Oct-a Of the Scp And The Dcp In Diabetic Patientsmentioning

confidence: 99%

Optical Coherence Tomography Angiography in Healthy Subjects and Diabetic Patients

et al. 2017

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Fluorescein angiography and indocyanine green angiography provide information about the normal retinal and choroidal vascular perfusion. They allow the evaluation of different diseases and increase the capability to define and diagnose several pathological conditions. Fluorescein angio graphy is the “gold standard” in imaging the retinal vascular bed and its changes, although not all the different layers of the capillary network can be visualized in a bidimensional examination. Optical coherence tomography angiography allows a depth-resolved visualization of the retinal and choroidal microvasculature, by calculating the difference (decorrelation) between static and nonstatic tissue. Given that the main moving elements in the eye fundus are contained in vessels, determining a vascular decorrelation signal permits a three-dimensional visualization of the retinal and choroidal vascular network without the administration of an intravenous dye. Moreover, a complete morphofunctional assessment may help in defining both the origin and the clinical activity of different vascular diseases such as diabetic retinopathy.

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Automated Quantitative Analysis of Retinal Microvasculature in Normal Eyes on Optical Coherence Tomography Angiography

Cited by 97 publications

References 36 publications

Choroidal Vascular Reactivity in Central Serous Chorioretinopathy

Choroidal Vascular Reactivity in Central Serous Chorioretinopathy

Retinal Microvasculature in Nonproliferative Diabetic Retinopathy: Automated Quantitative Optical Coherence Tomography Angiography Assessment

Optical Coherence Tomography Angiography in Healthy Subjects and Diabetic Patients

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