Automated quantification of photoreceptor outer segments in developing and degenerating retinas on microscopy images across scales
Suse Seidemann,
Florian Salomon,
Karl B. Hoffmann
et al.
Abstract:The functionality of photoreceptors, rods, and cones is highly dependent on their outer segments (POS), a cellular compartment containing highly organized membranous structures that generate biochemical signals from incident light. While POS formation and degeneration are qualitatively assessed on microscopy images, reliable methodology for quantitative analyses is still limited. Here, we developed methods to quantify POS (QuaPOS) maturation and quality on retinal sections using automated image analyses. POS f… Show more
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