Automated production of [sup 124]I and [sup 64]Cu using IBA Terimo and Pinctada metal electroplating and processing modules

Abstract

Abstract. There is worldwide growing interest for the production of long-lived positron emitters for molecular imaging and the development of novel immuno-PET techniques for drugs discovery. The desire to produce solid target isotopes in Australia has significantly increased over the years and several research projects for labelling of peptides, proteins and biomolecules, including labelling of recombinant antibodies has been limited due to the availability of suitable isotopes. This has led to the recent installation and commissioning of a new lab dedicated to fully automated solid target isotope production, including 124 I, 64 Cu, 89 Zr and 86 Y.

Production of novel diagnostic radionuclides in small medical cyclotrons

“…This gives the possibility to produce them with most cyclotrons. The developments in the last 20 years focused on the design of more efficient solid target systems (Kakavand et al, 2008 ; Mahunka et al, 1996 ; Al-Yanbawi and Al Jammaz, 2007 ; Nagatsu et al, 2011 ; Qaim et al, 2003 ; Poniger et al, 2012 ). TeO 2 based thin layer targets can be used for the production of both iodines using the same target, by changing only the tellurium target isotope to match the reactions 123 Te(p,n) 123 I or 124 Te(p,n) 124 .…”

“…In optimal situations, this method can produce up to 185 GBq (Ikotun and Lapi, 2011 ) after a long beam time of up to 8 h and currents up to 40 μA with various target thicknesses and proton energies applied, but typically lower yields are enough to supply local area customers for a few days (Avila-Rodriguez, Nye, and Nickles, 2007 ; Matarrese et al, 2010 ; Szelecsényi, Blessing, and Qaim, 1993 ). With radionuclide production secured, recent developments in 64 Cu focus on successful automation of the radiochemistry (Poniger et al, 2012 ; Matarrese et al, 2010 ; Ohya et al, 2016 ) and developments of reliable tracers carrying 64 Cu (Jalilian and Osso, 2017 ).…”

A clinical trial of non-invasive imaging with an anti-HIV antibody labelled with copper-64 in people living with HIV and uninfected controls

“…The positron emitting isotope 64 Cu has a half life of 12.8 hours allowing for effective doses of radiation under 5 milliSieverts, a dose considered acceptable for healthy volunteers. 64 Cu was produced in the cyclotron at the Department of Molecular Imaging and Therapy at Austin Health, Melbourne using standardised methods as previously described [16].…”

Electrochemical deposition of nickel targets from aqueous electrolytes for medical radioisotope production in accelerators: a review

“…As an example, vacuum evaporation of the acid is sometimes carried out for as long as 24 h [62]. Solvents less often applied for dissolution of the metallic Ni include HCl and H 2 SO 4 [10,33,34,37,55,57,59,84]. The dissolution can be facilitated by using oxidising agents, such as H 2 O 2 [10,57,59].…”

“…Typical substrates used here include solid (disc, foil etc.) polycrystalline Au [13, 17, 19, 25, 32-34, 38, 42, 47-49, 51, 53, 55, 56, 60, 83, 188], Pt [34,46,50], Ag [12,37,39] and Cu, the latter covered with a thin protective layer of Au or Ag [34,41,52,93,95]. The latter are intended to prevent the copper from dissolution when the target is in contact with the acids.…”