Automated production of 11C‐labeled carboxylic acids and esters via “in‐loop” 11C‐carbonylation using GE FX synthesis modules
Tanpreet Kaur,
Jay S. Wright,
Bradford D. Henderson
et al.
Abstract:An in‐loop 11C‐carbonylation process for the radiosynthesis of 11C‐carboxylic acids and esters from halide precursors has been developed. The reaction proceeds at room temperature under mild conditions and enables 11C‐carbonylation of both electron deficient and electron rich (hetero)aromatic halides to provide 11C‐carboxylic acids and esters in good to excellent radiochemical yields, high radiochemical purity, and excellent molar activity. The process has been fully automated using commercial radiochemistry s… Show more
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