“…Crisalle, Soper, Mellichamp, & Seborg, 1992), and local control, often in single-input single-output configuration (e.g. Schneider, Smyth, & Watts, 2001). Run to run (R2R) control is a form of discrete process control in which the product recipe is modified between runs or batches, to minimize the effects of process drifts, caused by factors such as the aging of the equipment or chemicals, and process shifts, often an outcome of upstream failures.…”