Automated oxygen delivery for preterm infants with respiratory dysfunction

Automated oxygen titration in term newborns and young infants: A randomised crossover study

“…Manual titration of oxygen therapy is known in preterm newborns to be associated with a high proportion of time spent outside the set target range (TR) for oxygen saturation measured by pulse oximetry (SpO 2 ) 2 . For such infants, automated titration of oxygen therapy guided by closed‐loop algorithms has now emerged as a viable alternative, which compared to manual control can result in more time spent in the SpO 2 TR 3 . Given that ventilators with capability for automated oxygen control are increasingly being used for respiratory support of mature newborns and young infants, there is a need for investigation of the impact of automated oxygen titration in these patient groups.…”

“…Term and near-term infants with respiratory dysfunction represent a population with significant morbidity and mortality. 1 Whilst the efficacy of automated oxygen control in preterm infants is widely documented, 3 the significance of the present study is its application in term newborns, a population with only one published study, 4 and young infants with RTI, a previously unstudied but common inpatient population. The effects of exposure to excessive supplemental oxygen and resultant hyperoxaemia are often discussed in the context of pre-term infants, but the newborn lung and brain of term infants are also vulnerable to oxygen-induced injury, due to the production of reactive oxygen species (ROS).…”