Automated Optimization of a Multistep, Multiphase Continuous Flow Process for Pharmaceutical Synthesis
Sarah L. Boyall,
Holly Clarke,
Thomas Dixon
et al.
Abstract:Flow synthesis is becoming increasingly relevant as a sustainable and safe alternative to traditional batch processes, as reaction conditions that are not usually achievable in batch chemistry can be exploited (for example, higher temperatures and pressures). Telescoped continuous reactions have the potential to reduce waste by decreasing the number of separate unit operations (e.g., crystallization, filtration, washing, and drying), increase safety due to limiting operator interaction with potentially harmful… Show more
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