Automated Neuropsychological Assessment Metrics: Repeated Assessment with Two Military Samples

Eonta, Stephanie E.; Carr, Walter; McArdle, Joseph J.; Kain, Jason M.; Tate, Charmaine; Wesensten, Nancy J.; Norris, Jacob; Balkin, Thomas J.; Kamimori, Gary H.

doi:10.3357/asem.2799.2011

Cited by 34 publications

(20 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Detailed descriptions of these subtests can be found elsewhere [15]. For the purposes of this study, we analyzed the TBI questionnaire and the performance subtests: Simple Reaction Time (SRT), Procedural Reaction Time (PRO), Coded Substitution (CDS), Matching to Sample (M2S), Mathematical Processing (MTH), Code Substitution Delayed (CDD), and Simple Reaction Time Repeated (SRT2).…”

Section: Methodsmentioning

confidence: 99%

Analysis of Post-Deployment Cognitive Performance and Symptom Recovery in U.S. Marines

et al. 2013

View full text Add to dashboard Cite

BackgroundComputerized neurocognitive testing (NCAT) has been proposed to be useful as a screening tool for post-deployment cognitive deficits in the setting of mild traumatic brain injury (mTBI). We assessed the clinical utility of post-injury/post-deployment Automated Neurocognitive Assessment Metric (ANAM) testing, using a longitudinal design to compare baseline ANAM tests with two post-deployment ANAM tests in a group of Marines who experienced combat during deployment.Methods and FindingsPost-deployment cognitive performance and symptom recovery were compared in a subsample of 1324 U.S. Marines with high rates of combat exposure during deployment. Of the sample, 169 Marines had available baseline and twice repeated post-deployment ANAM results. A retrospective analysis of the ANAM data, which consisted of a self-report questionnaire about deployment-related blast exposure, recent history of mTBI, current clinical symptoms, and cognitive performance. Self-reported concussion sustained anytime during deployment was associated with a decrease in cognitive performance measured between 2–8 weeks post-deployment. At the second post-deployment test conducted on average eight months later, performance on the second simple reaction time test, in particular, remained impaired and was the most consistent and sensitive indicator of the cognitive decrements. Additionally, post-concussive symptoms were shown to persist in injured Marines with a self-reported history of concussion for an additional five months after most cognitive deficits resolved. Results of this study showed a measurable deployment effect on cognitive performance, although this effect appears to resolve without lasting clinical sequelae in those without history of deployment-related concussion.ConclusionsThese results highlight the need for a detailed clinical examination for service members with history of concussion and persistent clinical symptoms. Reliance solely upon computerized neurocognitive testing as a method for identifying service members requiring clinical follow-up post-concussion is not recommended, as cognitive functioning only slowly returned to baseline levels in the setting of persistent clinical symptoms.

show abstract

Section: Methodsmentioning

confidence: 99%

Analysis of Post-Deployment Cognitive Performance and Symptom Recovery in U.S. Marines

et al. 2013

View full text Add to dashboard Cite

show abstract

“…The ANAM4 has been administered to military and sports-related concussion, exposure to radiation, high altitude, undersea, and toxic conditions (Bleiberg et al, 2004;Eonta et al, 2011). Furthermore, the ANAM4 was developed to minimize the learning effect and provides randomized stimuli across testing sessions and almost limitless number of alternative forms and facilitate repeated-measures testing ( Roebuck-Spencer et al, 2007;Eonta et al, 2011).…”

Section: Cognitive Task Measurementmentioning

confidence: 99%

The Influence of Exercise on Cognitive Performance in Normobaric Hypoxia

Seo

Burns

Fennell

et al. 2015

High Altitude Medicine & Biology

View full text Add to dashboard Cite

Although previous reports indicate that exercise improves cognitive function in normoxia, the influence of exercise on cognitive function in hypoxia is unknown. The purpose of this study was to determine if the impaired cognitive function in hypoxia can be restored by low to moderate intensity exercise. Sixteen young healthy men completed the ANAM versions of the Go/No-Go task (GNT) and Running Memory Continuous Performance Task (RMCPT) in normoxia to serve as baseline (B-Norm) (21% O2). Following 60 minutes of exposure to normobaric hypoxia (B-Hypo) (12.5% O2), these tests were repeated at rest and during cycling exercise at 40% and 60% of adjusted Vo2max. At B-Hypo, the % correct (p≤0.001) and throughput score (p≤0.001) in RMCPT were significantly impaired compared to B-Norm. During exercise at 40% (p=0.023) and 60% (p=0.006) of adjusted Vo2max, the throughput score in RMCPT improved compared to B-Hypo, and there was no significant difference in throughput score between the two exercise intensities. Mean reaction time also improved at both exercise intensities compared to B-Hypo (p≤0.028). Both peripheral oxygen saturation (Spo2) and regional cerebral oxygen saturation (rSo2) significantly decreased during B-Hypo (p≤0.001) and further decreased at 40% (p≤0.05) and 60% (p≤0.039) exercise. There was no significant difference in Spo2 or rSo2 between two exercise intensities. These data indicate that low to moderate exercise (i.e., 40%-60% adjusted Vo2max) may attenuate the risk of impaired cognitive function that occurs in hypoxic conditions.

show abstract

“…1 Sleep disturbances include sleeping more or less than usual, trouble falling asleep, and daytime drowsiness, and are typically assessed by administration of a multi-modal survey instrument. [2][3][4] The reference standard for evaluating sleep disturbances in humans is polysomnography (PSG) with a multi-channel electroencephalography system, 5 typically performed in a sleep center or, increasingly, at home. More recently, to provide a familiar sleep setting, as well as long-term day and night monitoring, researchers have used actigraphy measurements made by wearable accelerometers that reduce data collection cost and do not restrict patient movement.…”

Section: Introductionmentioning

confidence: 99%

Alterations in Daytime and Nighttime Activity in Piglets after Focal and Diffuse Brain Injury

Olson

Badder

Sullivan

et al. 2016

Journal of Neurotrauma

View full text Add to dashboard Cite

We have developed and implemented a noninvasive, objective neurofunctional assessment for evaluating the sustained effects of traumatic brain injury (TBI) in piglets with both diffuse and focal injury types. Derived from commercial actigraphy methods in humans, this assessment continuously monitors the day/night activity of piglets using close-fitting jackets equipped with tri-axial accelerometers to monitor movements of the thorax. Acceleration metrics were correlated (N = 7 naïve piglets) with video images to define values associated with a range of activities, from recumbancy (rest) to running. Both focal (N = 8) and diffuse brain injury (N = 9) produced alterations in activity that were significant 4 days post-TBI. Compared to shams (N = 6) who acclimated to the animal facility 4 days after an anesthesia experience by blurring the distinction between day and night activity, post-TBI time-matched animals had larger fractions of inactive periods during the daytime than nighttime, and larger fractions of active time in the night were spent in high activity (e.g., constant walking, intermittent running) than during the day. These persistent disturbances in rest and activity are similar to those observed in human adults and children post-TBI, establishing actigraphy as a translational metric, used in both humans and large animals, for assessment of injury severity, progressions, and intervention.

show abstract

Automated Neuropsychological Assessment Metrics: Repeated Assessment with Two Military Samples

Abstract: Results are consistent with expectations that multiple test sessions are required to reach stable performance on some computerized tasks. These results have implications for taking ANAM4 TBI Battery practice effects into account in test administration and in data interpretation.

Cited by 34 publications

References 24 publications

Analysis of Post-Deployment Cognitive Performance and Symptom Recovery in U.S. Marines

Analysis of Post-Deployment Cognitive Performance and Symptom Recovery in U.S. Marines

The Influence of Exercise on Cognitive Performance in Normobaric Hypoxia

Alterations in Daytime and Nighttime Activity in Piglets after Focal and Diffuse Brain Injury

Contact Info

Product

Resources

About