Automated Identification and Quantification of Subretinal Fibrosis in Neovascular Age-Related Macular Degeneration Using Polarization-Sensitive OCT

Roberts, Philipp; Sugita, Mitsuro; Deák, Gábor; Baumann, Bernhard; Zotter, Stefan; Pircher, Michael; Sacu, Stefan; Hitzenberger, Christoph K.; Schmidt‐Erfurth, Ursula

doi:10.1167/iovs.15-18694

Cited by 41 publications

(40 citation statements)

References 38 publications

(48 reference statements)

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“…Thus, these patterns do not match exactly and, especially in doubtful cases, can lead to misinterpretations. The occurrence of the patchy structures is similar to what has been reported earlier by Roberts et al 26 and could reflect an irregular pattern of inflammation and healing processes. The development of subretinal fibrosis is similar to that of fibrosis in other parts of the body; tissue inflammation causes the release of mediators recruiting inflammatory cells and fibroblasts.…”

Section: Discussionsupporting

confidence: 89%

“…PS-OCT makes use of the birefringent properties of fibrosis to establish its presence, offering an additional and potentially more reliable detection method. [25][26][27] In most cases with a birefringent signal, the fibrotic lesions showed a spatially heterogeneous patchy structure rather than a uniform birefringent layer. Those correlate with the occurrence of yellow-whitish lesions in the fundus images and formation of a hyperreflective layer in the structural images (in clear cases) but show more details of the local distribution of fibrotic tissue.…”

Section: Discussionmentioning

confidence: 99%

“…6 SRFib has therefore birefringent characteristics, allowing it to be visualized by polarization-sensitive OCT (PS-OCT). [25][26][27] This makes PS-OCT a promising tool for reliable detection and three-dimensional delineation of fibrotic tissue within (sub)retinal lesions.…”

Section: Introductionmentioning

confidence: 99%

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Subretinal Fibrosis Detection Using Polarization Sensitive Optical Coherence Tomography

Gräfe

Kreeke

Willemse

et al. 2020

Trans. Vis. Sci. Tech.

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Citation: Gräfe MGO, van de Kreeke JA, Willemse J, Braaf B, de Jong Y, Tan HS, Verbraak FD, de Boer JF. Subretinal fibrosis detection using polarization sensitive optical coherence tomography. Trans Vis Sci Tech. 2020;9(4):13, https://doi.org/10. 1167/tvst.9.4.13 Purpose: Subretinal fibrosis (SRFib) is an important cause of permanent loss-of-vision diseases with submacular neovascularization, but a reliable diagnostic method is currently missing. This study uses polarization-sensitive optical coherence tomography (PS-OCT) to detect SRFib within retinal lesions by measurement of its birefringent collagen fibers.Methods: Twenty-five patients were enrolled with retinal pathology in one or both eyes containing (1) suspected SRFib, (2) lesions suspected not to be fibrotic, or (3) lesions with doubtful presence of SRFib. All eyes were evaluated for SRFIb using conventional diagnostics by three retinal specialists. PS-OCT images were visually evaluated for SRFib based on cumulative phase retardation, local birefringence, and optic axis uniformity.Results: Twenty-nine eyes from 22 patients were scanned successfully. In 13 eyes, SRFib was diagnosed by all retinal specialists; of these, 12 were confirmed by PS-OCT and one was inconclusive. In nine eyes, the retinal specialists expected no SRFib, which was confirmed by PS-OCT in all cases. In seven eyes, the retinal specialists' evaluations were inconsistent with regard to the presence of SRFib. PS-OCT confirmed the presence of SRFib in four of these eyes and the absence of SRFib in two eyes and was inconclusive in one eye. Conclusions:In 21 out of 22 eyes, PS-OCT confirmed the evaluation of retinal specialists regarding the presence of SRFib. PS-OCT provided additional information to distinguish SRFib from other tissues within subretinal neovascular lesions in 6 out of 7 eyes.Translational Relevance: PS-OCT can identify and quantify SRFib in doubtful cases for which a reliable diagnosis is currently lacking.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

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Subretinal Fibrosis Detection Using Polarization Sensitive Optical Coherence Tomography

Gräfe

Kreeke

Willemse

et al. 2020

Trans. Vis. Sci. Tech.

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“…A recent study using a PS-OCT system with an integrated retinal tracker [125] -which is important since the fixation capability of affected patients is usually poor, leading to heavy motion artifacts -demonstrated that fibrotic lesions can be readily identified and in the majority of cases also segmented by their characteristic birefringence patterns, showing column-like axis orientation patterns in PS-OCT B-scans (cf. Figure 18) [126]. The combination of PS-OCT with OCT angiography provides further insights into neovascular lesions in AMD patients [127].…”

Section: Imaging Of Macular Lesionsmentioning

confidence: 99%

Polarization sensitive optical coherence tomography – a review [Invited]

Boer¹,

Hitzenberger

Yasuno

2017

Biomed. Opt. Express

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332

217

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Abstract:Optical coherence tomography (OCT) is now a well-established modality for highresolution cross-sectional and three-dimensional imaging of transparent and translucent samples and tissues. Conventional, intensity based OCT, however, does not provide a tissuespecific contrast, causing an ambiguity with image interpretation in several cases. Polarization sensitive (PS) OCT draws advantage from the fact that several materials and tissues can change the light's polarization state, adding an additional contrast channel and providing quantitative information. In this paper, we review basic and advanced methods of PS-OCT and demonstrate its use in selected biomedical applications. Drexler, and J. G. Fujimoto, eds. (Springer, Cham, 2015), pp. 1137-1162. 6. J. F. de Boer and T. E. Milner, "Review of polarization sensitive optical coherence tomography and Stokes vector determination," J. Biomed. Opt. 7(3), 359-371 (2002). 7. M. Pircher, C. K. Hitzenberger, and U. Schmidt-Erfurth, "Polarization Sensitive Optical Coherence Tomography in the Human Eye," Prog. Retin. Eye Res. 30(6), 431-451 (2011). 8. D. Stifter, "Beyond biomedicine: a review of alternative applications and developments for optical coherence tomography," Appl. Phys. B 88(3), 337-357 (2007). 9. R. C. Jones, "A new calculus for the treatment of optical systems I. Description and discussion of the calculus," J. Opt. Soc. Am. A 31(7), 488-493 (1941). 10. J. J. Gil and E. Bernabeu, "Obtainment of the polarizing and retardation parameters of a non-depolarizing optical system from the polar decomposition of its Mueller matrix," Optik (Stuttg.) 76, 67-71 (1987). 11. C. F. Bohren and D. R. Huffman, Absorption and Scattering of Light by Small Particles (Wiley Interscience, New York, NY, 1983). 12. W. A. Shurcliff and S. S. Ballard, Polarized Light (Van Nostrand, New York, 1964). 13. B. H. Park, C. Saxer, S. M. Srinivas, J. S. Nelson, and J. F. de Boer, "In vivo burn depth determination by highspeed fiber-based polarization sensitive optical coherence tomography," J. Biomed. Opt. 6(4), 474-479 (2001). 14. B. H. Park, M. C. Pierce, B. Cense, and J. F. de Boer, "Real-time multi-functional optical coherence tomography," Opt. Express 11(7), 782-793 (2003). 15. C. E. Saxer, J. F. de Boer, B. H. Park, Y. Zhao, Z. Chen, and J. S. Nelson, "High-speed fiber based polarizationsensitive optical coherence tomography of in vivo human skin," Opt. Lett. 25(18), 1355-1357 (2000). Rylander, "Polarization sensitive optical coherence tomography of the rabbit eye," IEEE J. Sel. Top. Quantum Electron. 5(4), 1159-1167 (1999 Schmidt-Erfurth, and S. Sacu, "Retinal pigment epithelial features in central serous chorioretinopathy identified by polarization-sensitive optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 57(4), 1595-1603 (2016). 131. C. Schütze, C. Ahlers, M. Pircher, B. Baumann, E. Götzinger, F. Prager, G. Matt, S. Sacu, C. K. Hitzenberger, and U. Schmidt-Erfurth, "Morphologic characteristics of idiopathic juxtafoveal telangiectasia using spectraldomain and po...

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“…In late stage non-exudative (dry) AMD, PS-OCT enables the assessment of atrophic areas lacking RPE (Figure 5a-d) [121,157,158]. In exudative diseases such as wet AMD, central serous chorioretinopathy, and diabetic macular edema, PS-OCT was demonstrated for imaging and identifying fibrotic scars, hard exudates, as well as pigment epithelial features [123,[159][160][161][162]. Finally, PS-OCT also proved useful to enhance contrast for imaging pathologic structures in less common retinal diseases such as macular telangiectasia and Stargardt disease [163,164].…”

Section: Ps-oct In the Eyementioning

confidence: 99%

Polarization Sensitive Optical Coherence Tomography: A Review of Technology and Applications

Baumann

2017

Applied Sciences

Self Cite

125

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Polarization sensitive optical coherence tomography (PS-OCT) is an imaging technique based on light scattering. PS-OCT performs rapid two-and three-dimensional imaging of transparent and translucent samples with micrometer scale resolution. PS-OCT provides image contrast based on the polarization state of backscattered light and has been applied in many biomedical fields as well as in non-medical fields. Thereby, the polarimetric approach enabled imaging with enhanced contrast compared to standard OCT and the quantitative assessment of sample polarization properties. In this article, the basic methodological principles, the state of the art of PS-OCT technologies, and important applications of the technique are reviewed in a concise yet comprehensive way.

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Automated Identification and Quantification of Subretinal Fibrosis in Neovascular Age-Related Macular Degeneration Using Polarization-Sensitive OCT

Cited by 41 publications

References 38 publications

Subretinal Fibrosis Detection Using Polarization Sensitive Optical Coherence Tomography

Subretinal Fibrosis Detection Using Polarization Sensitive Optical Coherence Tomography

Polarization sensitive optical coherence tomography – a review [Invited]

Polarization Sensitive Optical Coherence Tomography: A Review of Technology and Applications

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