Automated Estimation of Collagen Fibre Dispersion in the Dermis and its Contribution to the Anisotropic Behaviour of Skin

Annaidh, Aisling Ní; Bruyère-Garnier, Karine; Destrade, Michel; Gilchrist, Michael D.; Maurini, Corrado; Otténio, Melanie; Saccomandi, Giuseppe

doi:10.1007/s10439-012-0542-3

Cited by 166 publications

(162 citation statements)

References 30 publications

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“…Wu et al (2006) reported a tensile Young's modulus of 3 MPa at 100% relative humidity (RH) to 370 MPa at 30% RH. Although some authors have developed computational models of the skin (Groves et al, 2013;Limbert, 2011;Ní Annaidh et al, 2012) or the dermis (Flynn andMcCormack, 2009, 2010) which account for the anisotropic properties induced by the presence of collagen fibres, this approach is not followed in the current research for two main reasons. The first reason is motivated by the decision to keep the model as simple as possible to facilitate the interpretation of results and to focus on structural rather than material effects.…”

Section: Mechanical Properties Of Skinmentioning

confidence: 99%

A mechanistic insight into the mechanical role of the stratum corneum during stretching and compression of the skin

Leyva-Mendivil

Page

Bressloff

et al. 2015

Journal of the Mechanical Behavior of Biomedical Materials

108

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A mechanistic insight into the mechanical role of the stratum corneum during stretching and compression of the skin. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.www.elsevier.com/locate/jmbbm 1 A mechanistic insight into the mechanical role of the stratum corneum during stretching and compression of the skin. AbstractThe study of skin biophysics has largely been driven by consumer goods, biomedical and cosmetic industries which aim to design products that efficiently interact with the skin and/or modify its biophysical properties for health or cosmetic benefits. The skin is a hierarchical biological structure featuring several layers with their own distinct geometry and mechanical properties. Up to now, no computational models of the skin have simultaneously accounted for these geometrical and material characteristics to study their complex biomechanical interactions under particular macroscopic deformation modes.The goal of this study was, therefore, to develop a robust methodology combining histological sections of human skin, image-processing and finite element techniques to address fundamental questions about skin mechanics and, more particularly, about how macroscopic strains are transmitted and modulated through the epidermis and dermis. The work hypothesis was that, as skin deforms under macroscopic loads, the stratum corneum does not experience significant strains but rather folds/unfolds during skin extension/compression.A sample of fresh human mid-back skin was processed for wax histology. Sections were stained and photographed by optical microscopy. The multiple images were stitched together to produce a larger region of interest and segmented to extract the geometry of the stratum corneum, viable epidermis and dermis. From the segmented structures a 2D finite element mesh of the skin composite model was created and geometrically non-linear plane-strain finite element analyses were conducted to study the sensitivity of the model to variations in mechanical properties.The hybrid experimental-computational methodology has offered valuable insights into the simulated mechanics of the skin, and that of the stratum corneum in particular, by providing qualitative and quantitative information on strain magnitude and distribution. Through a complex non-linear interplay, the geometry and mechanical characteristics of the skin layers (and their relative balance), play a critical role in conditioning the skin mechanical response to macroscopic in-plane compression and extension. Topographical features of the skin surface such as furrows were shown to act as an efficient means to deflec...

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Section: Mechanical Properties Of Skinmentioning

confidence: 99%

A mechanistic insight into the mechanical role of the stratum corneum during stretching and compression of the skin

Leyva-Mendivil

Page

Bressloff

et al. 2015

Journal of the Mechanical Behavior of Biomedical Materials

108

View full text Add to dashboard Cite

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“…(Horgan and Saccomandi, 2003;Li and Robertson, 2009;Tsamis et al, 2013), damage and remodeling (Ferrara and Pandolfi, 2008;Ni Annaidh et al, 2012;Sánchez et al, 2014). As a consequence of the intrinsically patient-specific nature and of the microstructural complexity of biological tissues, their modeling is very challenging and still incomplete.…”

Section: Introductionmentioning

confidence: 99%

Statistical characterization of the anisotropic strain energy in soft materials with distributed fibers

Gizzi

Pandolfi

Vasta

2016

Mechanics of Materials

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a b s t r a c tWe discuss analytical and numerical tools for the statistical characterization of the anisotropic strain energy density of soft hyperelastic materials embedded with fibers. We consider spatially distributed orientations of fibers following a tridimensional or a planar architecture. We restrict our analysis to material models dependent on the fourth pseudo-invariant I 4 of the Cauchy-Green tensor, and to exponential forms of the fiber strain energy function aniso . Under different loading conditions, we derive the closed-form expression of the probability density function for I 4 and aniso . In view of bypassing the cumbersome extension-contraction switch, commonly adopted for shutting down the contribution of contracted fibers in models based on generalized structure tensors, for significant loading conditions we identify analytically the support of the fibers in pure extension. For uniaxial loadings, the availability of the probability distribution function and the knowledge of the support of the fibers in extension yield to the analytical expression of average and variance of I 4 and aniso , and to the direct definition of the average second Piola-Kirchhoff stress tensor. For generalized loadings, the dependence of I 4 on the spatial orientation of the fibers can be analyzed through angle plane diagrams. Angle plane diagrams facilitate the assessment of the influence of the pure extension condition on the definition of the stable support of fibers for the statistics related to the anisotropic strain energy density.

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“…In this study, nonlinear material model of human tissue was represented by the Gasser-Ogden-Holzapfel material model. Annaidh, Bruyere [23] have successfully applied the Gasser-OgdenHolzapfel model to simulate the anisotropic behaviour of human tissue. In their study, the model was limited to simulating tensile tests in predicting the response of the mechanical behaviour of human tissue.…”

Section: Mechanical Propertiesmentioning

confidence: 99%

“…The material properties of human tissue obtained from experimental data of previous researchers with ABAQUS parameters used in this study were , and [23]. Table 2 shows the material parameters that are used in this study to define general soft human tissue.…”

Section: Mechanical Propertiesmentioning

confidence: 99%

Pressure sores of human tissue damage during pelvic binder compression

Munandar

Huzni

Ismail

et al. 2016

Int. J. Automot. Mech. Eng.

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Pelvic circumferential compression is a device used to reduce injury which inadvertently, cause soft tissue damage. When force is applied excessively to the pelvic binder, tissue is damaged due to prolonged high pressure. Therefore, effect from this interaction between tissue and pelvic binder is an important factor to avoid pressure sores due to human tissue damage. The aim of this study is to investigate the effects of human tissue interaction due to compression of the pelvic binder using a finite element modelling approach. A three-dimensional human pelvic model was developed to simulate pressure distribution on tissue interfaces. The applied loads with two different conditions -dry and wet skin were applied on both tips of the pelvic strap during binder-tissue interaction. The compression load of the pelvic binder was estimated on a pelvic strap in order to reduce pelvic fracture. The compression load was varied substantially between locations as well as between skin conditions. There were two straps on the pelvis. For pelvic strap 1, the pressure on the sacrum and ilium was higher than the pressure measured on pelvic strap 2 while pressure on the anterior area was the same for both pelvic straps. Analysis results showed that the pressure which developed between both tissue and pelvic binder exceeded the recommended pressure i.e. ≥ 9.3 kPa at tissue interfaces. When pressure on tissue interfaces is not controlled, this condition can lead to tissue damage due to prolonged periods of time. Hence, to avoid tissue damage to the pelvic binder a cushion must be introduced to reduce the effect of tissue reaction from the prehospital device. Subsequently, tissue and pelvic binder interaction simulation results were compared with experimental data for validation in the model developed.

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Automated Estimation of Collagen Fibre Dispersion in the Dermis and its Contribution to the Anisotropic Behaviour of Skin

Cited by 166 publications

References 30 publications

A mechanistic insight into the mechanical role of the stratum corneum during stretching and compression of the skin

A mechanistic insight into the mechanical role of the stratum corneum during stretching and compression of the skin

Statistical characterization of the anisotropic strain energy in soft materials with distributed fibers

Pressure sores of human tissue damage during pelvic binder compression

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