Automated determination of neutrophil VCS parameters in diagnosis and treatment efficacy of neonatal sepsis

Neutrophil volume, conductivity and scatter parameters with effective modeling of molecular activity statistical program gives better results in neonatal sepsis

“…We previously reported the value of mean neutrophil volume (MNV), conductivity (MNC), scatter (MNS) and distribution width (DW) of these parameters in diagnosis and treatment efficacy evaluation of neonatal sepsis. We found that combination of IL‐6, CRP, and neutrophil VCS parameters was better than the usage of each parameters alone . Statistical models can be used to strengthen the diagnosis.…”

“…We previously reported IL‐6 and CRP cutoff levels in neonatal sepsis . Currently, there is no perfect marker to diagnose sepsis, and combination of markers and diagnostic models strengthens the diagnosis .…”

Quantitative and volume, conductivity and scatter changes in leucocytes of patients with acute undifferentiated febrile illness: a pilot study: Table 1.

“…3 The VCS technology has been used to evaluate morphologic changes within the same cell population, such as the changes occurring in neutrophils during acute bacterial infection. Celik et al 4 studied the levels of neutrophil VCS parameters in neonatal sepsis and observed significant increases in mean neutrophil volume (NV), neutrophil volume distribution width (NVDW), neutrophil conductivity distribution width (NCDW), and significant decreases in mean neutrophil conductivity (NC) and mean neutrophil scatter (NS). Significant decreases were observed in mean NV, NVDW, and NCDW, whereas mean NC and NS increased at the end of the treatment.…”

“…Gram-negative sepsis caused higher mean NV and NVDW than Gram-positive sepsis. 4 Lee and Kim 5 evaluated mean cell volumes of neutrophils and monocytes in elderly patients with sepsis. They observed that the mean NV and monocytes volume (MV) were higher in the sepsis group than in the localized infection and control groups (p<0.001 for both).…”

The Accuracy of Mean Neutrophil Volume Relative to Blood Culture for the Diagnosis of Sepsis: A Meta-analysis

“…Clinical and laboratory findings are used for the diagnosis, and the gold standard is blood culture. 1 Blood culture has its shortcomings, such as low sensitivity, the need for sterile collection techniques to avoid contamination, and false positivity. There is a delay of at least a 24-48 hours before results of blood culture are available.…”