Automated computer-based CT stratification as a predictor of outcome in hypersensitivity pneumonitis

Abstract

• Computer CT analysis better predicts mortality than visual CT analysis in HP. • Quantitative CT analysis is equivalent to functional indices for prognostication in HP. • Prognostication using the ILD-GAP model improves when combined with quantitative CT analysis.

Evaluation of visual and computer‐based CT analysis for the identification of functional patterns of obstruction and restriction in hypersensitivity pneumonitis

“…with 5 and 7 years of thoracic imaging experience, respectively, blinded to all clinical information. Visual CT scoring and consensus derivation have been previously described . CT patterns scored visually on a lobar basis included ground‐glass opacities, reticular pattern, honeycombing, consolidation, gas trapping (which comprised separate scores of emphysema and mosaic attenuation (the decreased attenuation component)) and traction bronchiectasis …”

Fibrotic Hypersensitivity Pneumonitis: Key Issues in Diagnosis and Management

“…Several studies have demonstrated that the presence and extent of fibrosis is predictive of mortality in HP [27,31,32]. In a mixed study group of 69 patients with subacute and chronic HP, severe impairment of pulmonary function and CT features of fibrosis were associated with a poor prognosis [31].…”

“…Traction bronchiectasis severity was also shown to be superior to lung function tests in prognostic determination [27]. New quantitative imaging techniques using automated computer-based CT (CALIPER) analysis have recently shown that the extent of reticulation on CT is an independent predictor of mortality in fibrotic HP [32]. …”

Pulmonary hypertension in combined pulmonary fibrosis and emphysema: A tale of two cities

“…It is reassuring that the findings were also robust using two definitions of CT disease extent. The use of computer‐based CT analysis is being increasingly used in the study of lung disease . A number of techniques have been described, including the texture classification method which allows the differentiation of parenchymal lung disease associated with both ILD and emphysema.…”

“…The use of computer-based CT analysis is being increasingly used in the study of lung disease. [9][10][11][12] A number of techniques have been described, including the texture classification method 9 which allows the differentiation of parenchymal lung disease associated with both ILD and emphysema. The most commonly used texture analysis method is CALIPER.…”