Automated cardiac pose computation from reconstructed myocardial SPECT images

Dwivedi, Shekhar; Liang, Hongjie; Ye, Jinghan; Silva, Angela J. Da; Wong, Alicia; Gervais, A.; Flowers, S. Swaim; Hines, Horace H.; Shao, L. G.

doi:10.1109/nssmic.2011.6153640

Cited by 1 publication

(1 citation statement)

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“…The long-axis was estimated by modeling the left ventricle as an ellipsoid. [21][22][23] The circumferential orientation was standardized by finding the mean direction of the right ventricle relative to the left ventricle. Figure 5 presents a representative four-chamber slice from an OCT dataset of the whole heart.…”

Section: Realignmentmentioning

confidence: 99%

Morphological phenotyping of mouse hearts using optical coherence tomography

et al. 2014

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Transgenic mouse models have been instrumental in the elucidation of the molecular mechanisms behind many genetically based cardiovascular diseases such as Marfan syndrome (MFS). However, the characterization of their cardiac morphology has been hampered by the small size of the mouse heart. In this report, we adapted optical coherence tomography (OCT) for imaging fixed adult mouse hearts, and applied tools from computational anatomy to perform morphometric analyses. The hearts were first optically cleared and imaged from multiple perspectives. The acquired volumes were then corrected for refractive distortions, and registered and stitched together to form a single, high-resolution OCT volume of the whole heart. From this volume, various structures such as the valves and myofibril bundles were visualized. The volumetric nature of our dataset also allowed parameters such as wall thickness, ventricular wall masses, and luminal volumes to be extracted. Finally, we applied the entire acquisition and processing pipeline in a preliminary study comparing the cardiac morphology of wild-type mice and a transgenic mouse model of MFS.

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Section: Realignmentmentioning

confidence: 99%